Evidence for a Role of Volatile Amines in the Development of Neonatal Hypergastrinemia

Lichtenberger, Lenard M.; Gardner, James W.; Barreto, José C.; Morriss, Frank H.

doi:10.1097/00005176-199111000-00002

Cited by 18 publications

(5 citation statements)

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“…Dimethylamine is a nitrogenous product, synthesised by bacterial action by the catabolism of trimethylamine or by the metabolism of choline and choline-containing phosphatides. In the literature, dimethylamine was found in sows’ serum [ 33 ], and in human milk [ 34 ], suggesting that dimethylamine can pass from mother’s serum to milk (and colostrum). Literature is lacking of studies on the effects of dimethylamine in newborn piglets; anyway it is generally accepted that this compound may have genotoxic [ 35 ] and irritant effects on mucosae [ 36 ], together with lethargy and coordination disorders in animals [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomics characterization of colostrum in three sow breeds and its influences on piglets’ survival and litter growth rates

Picone

Zappaterra

Luise

et al. 2018

J Animal Sci Biotechnol

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BackgroundColostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity, prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity. Thus, the aim of the present research is to provide new information about pig colostrum composition and the associations between metabolites, the sows’ breed and the survival and growth rates of their litters.ResultsColostrum samples were gathered from 58 parturitions of sows belonging to three different breeds chosen for their importance in Italian heavy pig production: 31 Large White, 15 Landrace and 12 Duroc respectively. The defatted and ultrafiltered colostrum samples were analysed using 1H–NMR spectroscopy. Principal Components Analysis (PCA) was assessed on the obtained spectra. In addition, using a Stepwise Regression and a Linear Regression analyses the metabolites named after the signals assignment were tested for their associations with piglets’ performances. Twenty-five metabolites were identified, comprehending monosaccharides, disaccharides (such as lactose), organic acids (lactate, citrate, acetate and formate), nitrogenous organic acids (such as creatine) and other compounds, including nucleotides. PCA results evidence a clustering due to breed and season effects. Lactose was the main compound determining the assignment of the samples into different clusters according to the sow breed. Furthermore, some metabolites showed to be associated with piglets’ performance and survival traits: acetate and taurine were positively related to litter weight gain and piglets’ survival rate, respectively, while dimethylamine and cis-aconitate were linked to new-borns’ impaired ability to survive.ConclusionsThe results obtained suggest that colostrum composition is affected by breed, which, together with environmental conditions, may cause changes in colostrum metabolites content with possible consequences on piglets’ performances. Among the identified metabolites, acetate, taurine, dimethylamine and cis-aconitate showed consistent associations with piglets’ survival rate and litter weight gain, implying that these compounds may affect new-borns’ ability to survive.Electronic supplementary materialThe online version of this article (10.1186/s40104-018-0237-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Metabolomics characterization of colostrum in three sow breeds and its influences on piglets’ survival and litter growth rates

Picone

Zappaterra

Luise

et al. 2018

J Animal Sci Biotechnol

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“…It can be Colostrum has been subjected to GC-MS analyses, demonstrating the presence of odorants that had been reported in milk before, including fatty acids, aldehydes, lactones, alcohols, amines, terpenes, and oxygen-containing heterocycles [1,67,116]. By directly comparing colostrum and mature milk samples, higher methylamine concentrations were detected in colostrum [63]. Similarly, Hartmann et al [71] detected amino acid conjugates of human sweat odorants in colostrum and milk samples, with higher concentrations in colostrum.…”

Section: Lactational Stagementioning

confidence: 96%

“…Further, some odorous compounds may be synthesized and secreted by the mammary or skin glands. Indeed, various volatile compounds occur in milk, with important inter-and intra-individual qualitative and quantitative variations [1,[61][62][63][64][65][66][67][68][69][70]. Further, amino acid conjugates known as precursors of sweat odour have been detected in milk [71], and might analogously contribute to milk odour after cleavage.…”

Section: Odorous Volatiles Of Milkmentioning

confidence: 99%

The odour of human milk: Its chemical variability and detection by newborns

Loos

Reger

Schaal

2019

Physiology & Behavior

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Human milk odour has for long elicited research interest with regard to its function in breastfeeding initiation. The present review aims to provide an overview of the behavioural effects of human milk odour in the human neonate, considering different types of response measures in a feeding or nonfeeding context. Further, an overview of the current knowledge of odorant composition and factors influencing milk odour is provided by summarizing results from analytical studies using olfactometry, and addressing changes in milk odour due to storage, lactational stage, and maternal dietary intake of odorous substances. We finally highlight some issues for future research.

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“…Lichtenberger et al have reported that hypergastrinemia may be related to high concentrations of volatile amines in the amniotic fluid [10,11]. The oxyntic glands, which are responsible for the acid secretion in the stomach, are present in the fetus during second trimester.…”

Section: Discussionmentioning

confidence: 99%

Erosive esophagitis with transient respiratory distress in newborns: a case report

Sasidharan

Chandramati

2017

Int J Pediatr Res

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Isolated esophagitis is very rare in newborn infants at birth, although it may occur a few days or weeks later but is generally associated with gastritis or gastroesophageal reflux, infections or trauma. Respiratory distress is a very unusual clinical feature of esophagitis. We hereby report two newborns who presented with symptoms of respiratory distress at birth and had isolated erosive esophagitis. Symptoms resolved with treatment of esophagitis.

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Evidence for a Role of Volatile Amines in the Development of Neonatal Hypergastrinemia

Cited by 18 publications

References 0 publications

Metabolomics characterization of colostrum in three sow breeds and its influences on piglets’ survival and litter growth rates

Metabolomics characterization of colostrum in three sow breeds and its influences on piglets’ survival and litter growth rates

The odour of human milk: Its chemical variability and detection by newborns

Erosive esophagitis with transient respiratory distress in newborns: a case report

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