Evidence for a role of the caudate nucleus in the sequential organization of behaviour

Bercken, J.H.L. van den; Cools, Alexander R.

doi:10.1016/0166-4328(82)90058-4

Cited by 67 publications

(29 citation statements)

References 32 publications

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“…The increased responding during CS (cue)-induced reinstatement following shell inactivation is suggestive of an inhibitory influence on the activation of CS-drug or response-drug associations, possibly arising from the environmental context. A possible role for the NAcc shell region in mediating such contextual effects derives from its close anatomical ( Van den Bercken and Cools, 1982;Groenewegen et al, 1987;Selden et al, 1990;McDonald and White, 1993;Floresco et al, 2001) associations with the hippocampus, as distinct from the NAcc core region, which receives afferents predominantly from the amygdala (Groenewegen et al, 1999). Moreover, hippocampal and amygdaloid projections to the NAcc often exert competing influences on behavior in response to contextual or discrete cues, respectively (Van den Bercken and Cools, 1982;Floresco et al, 2001), consistent with the opposed effects of NAcc core and NAcc shell inactivations in this experiment.…”

Section: Persistent Responding For a Conditioned Reinforcersupporting

confidence: 64%

Differential Effects of Nucleus Accumbens Core, Shell, or Dorsal Striatal Inactivations on the Persistence, Reacquisition, or Reinstatement of Responding for a Drug-Paired Conditioned Reinforcer

Ciano

Robbins

Everitt

2007

Neuropsychopharmacol

108

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Drug-paired conditioned reinforcers can maintain persistent instrumental responding, thus providing a model of some aspects of longterm drug addiction. The purpose of the present study was to investigate the effects of inactivating the dorsal striatum (DStr), nucleus accumbens (NAcc) core, or NAcc shell on different types of responding, each maintained by drug-paired conditioned reinforcers. Inactivations were achieved by infusing a combination of baclofen and muscimol prior to (1) persistent responding for a drug-paired conditioned reinforcer, (2) reacquisition of this instrumental response after extinction by omission of the contingent conditioned stimulus (CS), or (3) CS (cue)-induced reinstatement of the original (and different) instrumental response that had previously delivered cocaine. Inactivation of the DStr attenuated persistent responding for a cocaine-paired conditioned reinforcer, as well as its reacquisition after extinction of this response, while the only effect of inactivation of the NAcc shell was to increase CS (cue)-induced reinstatement of the extinguished instrumental response that had previously delivered cocaine. Inactivation of the NAcc core affected all measures of responding maintained by drug-paired conditioned reinforcers. These results are discussed with reference to the neural systems involved in different aspects of responding maintained by drug-paired conditioned reinforcers.

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Section: Persistent Responding For a Conditioned Reinforcersupporting

confidence: 64%

Differential Effects of Nucleus Accumbens Core, Shell, or Dorsal Striatal Inactivations on the Persistence, Reacquisition, or Reinstatement of Responding for a Drug-Paired Conditioned Reinforcer

Ciano

Robbins

Everitt

2007

Neuropsychopharmacol

108

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“…Regarding the deficits seen in the cognitive tests, table 6 clearly shows that there are significant differences between the two groups with respect to the criterion tests for "shifting aptitude" in the verbal and figural modality. First, word production tests: regarding the two alternative kinds of interpretations (see Methods, measurement of "shifting aptitude" and statistical analysis), table 6 shows that there are significant differences between the Parkinson and control group in both cases: table 6, column 1 (traditional interpretation) and table 6, column 5 (alternative interpretation, starting from the point of view that "word production 2" test reflects, in addition, a kind of higher-order "shifting aptitude"); as the regression of the shift phase scores on baseline scores was not parallel in the latter case (table 6, column 4) within-group regression was used for the statistical analysis (table 6, column 5).…”

Section: Deficits At the Cognitive Levelmentioning

confidence: 96%

Cognitive and motor shifting aptitude disorder in Parkinson's disease.

Cools¹,

Bercken²,

Horstink³

et al. 1984

Journal of Neurology, Neurosurgery & Psychiatry

353

135

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SUMMARY Eighteen patients suffering from Parkinson's disease and nineteen control subjects, who were matched for age and intelligence, were compared in tests measuring "shifting aptitude" at cognitive and motor levels (word production, sorting blocks or animals, and finger pushing sequences). It was found that Parkinson patients produced fewer different names of animals and professions in one minute than control subjects, needed more trials for detecting a shift in a sorting criterion, and produced fewer finger responses in a change of pushing sequence than control subjects. These results are interpreted as reflecting a central programming deficit that manifests itself in verbal, figural and motor modalities, that is, a diminished "shifting aptitude" characteristic of patients with dysfunctioning basal ganglia. The results are discussed in relation to changes of behaviour organisations in animals with dysfunctioning basal ganglia.For many years, the basal ganglia have been known to be involved in motor functioning. The basal ganglia are also believed to play a circumscribed role in programming ongoing behaviour.'-' There is, also, belief that the basal ganglia play a definite role in cognitive functioning.8-'3 (cf. refs 14-i5.) Of

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“…Interference with the functional interaction between dopamine-dependent associative processes in the basolateral amygdala and glutamate-dependent processes in the NAc core using bilateral infusions of the D 1/2/3 receptor antagonist ␣-flupenthixol or the AMPA/kainate receptor antagonist LY293558 (3SR, 4aRS, 6RS, 8aRS-6-[2-(iH-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroiso-quinoline-3-carboxylic acid), respectively, reduced cuemaintained cocaine seeking (Di Ciano and Everitt, 2004). Conversely, the role of the NAc shell region on behavior in response to contextual cues (Crombag et al, 2008) may derive from its anatomical connections with the hippocampus (Van den Bercken and Cools, 1982;Groenewegen et al, 1987;McDonald and White, 1993;Floresco et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats

Wang¹,

Luo²,

He³

et al. 2010

J. Neurosci.

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Relapse to drug seeking was studied using a rodent model of reinstatement induced by exposure to drug-related cues. The mammalian target of rapamycin (mTOR), a serine/threonine protein kinase that regulates cell growth and survival by controlling translation in response to nutrients and growth factors, has been demonstrated to be involved in neuronal adaptations that underlie drug addiction and learning and memory. We investigated the potential role of the mTOR signaling pathway in relapse to cocaine seeking by using the cue-induced reinstatement model in self-administering rats. We found that exposure to a cocaine-related cue induced reinstatement to cocaine seeking and increased phosphorylation of p70s6 kinase (p70s6k) and ribosomal protein s6 (rps6), measures of mTOR activity, in the nucleus accumbens (NAc) core but not shell. Furthermore, inhibition of NAc core but not shell p70s6k and rps6 phosphorylation by rapamycin decreased cue-induced reinstatement of cocaine seeking. Finally, stimulation of NAc core p70s6k and rps6 phosphorylation by NMDA enhanced cue-induced reinstatement, an effect reversed by rapamycin pretreatment. Additionally, rapamycin infusion into the NAc core or shell did not alter ongoing cocaine self-administration or cue-induced reinstatement of sucrose seeking. These findings indicate that cue-induced reinstatement of cocaine seeking is mediated by activation of the mTOR signaling pathway in the NAc core.

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Evidence for a role of the caudate nucleus in the sequential organization of behaviour

Cited by 67 publications

References 32 publications

Differential Effects of Nucleus Accumbens Core, Shell, or Dorsal Striatal Inactivations on the Persistence, Reacquisition, or Reinstatement of Responding for a Drug-Paired Conditioned Reinforcer

Differential Effects of Nucleus Accumbens Core, Shell, or Dorsal Striatal Inactivations on the Persistence, Reacquisition, or Reinstatement of Responding for a Drug-Paired Conditioned Reinforcer

Cognitive and motor shifting aptitude disorder in Parkinson's disease.

Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats

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