Evidence for a dominant role of prolactin in the luteotrophic complex of pseudopregnant goats

Taverne, M.A.M.; Bevers, M.M.; Hesselink, Jan Willem; Brande, H.J. van den; Dieleman, S.J.; Oord, H.A. van

doi:10.1016/0378-4320(94)90072-8

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…Accurate aetiology of the disease has not been fully discovered,3 4 but some risk factors were recently revealed 5 6. Accumulation of fluid in uterus is described as a consequence of the persistence of one or more corpora lutea (CL) in ovary 7. Thus, HD treatment consists in the drainage of uterine fluid which can be obtained with one or preferentially more administrations of prostaglandin F2α (PGF2α) 3 4 8.…”

Section: Introductionmentioning

confidence: 99%

Embryo development is impaired in goats that are treated for hydrometra and subsequently subjected to superovulation

Maia¹,

Arrais²,

Prellwitz³

et al. 2020

Veterinary Record

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BackgroundReproductive efficiency after hydrometra (HD) treatment is usually unsatisfactory.MethodsTo identify mechanisms involved in low reproductive efficiency of HD-treated goats, pluriparous dairy goats treated for HD (n=10, HD) or with no reproductive disorders (n=11, control: CONT) were induced to oestrus and superovulated. Goats were mated with fertile bucks and seven days after oestrus, non-surgical embryo recovery was performed. Embryos were evaluated and gene expression was performed.ResultsThere were no differences (P>0.05) in sexual behaviour parameters, superovulation response, mean number of retrieved structures and viable embryos between groups; although embryo recovery rate was higher (P=0.01) in CONT group. Structures in delayed stage (8–16 cells) were more frequent (P<0.05) in HD (29 vs 1 per cent) goats, as well as the percentage of advanced embryos was greater (P<0.05) for CONT (59.3 vs 33.3 per cent) goats. However, the expression of genes related to apoptosis (BAX and Bcl-2), trophectoderm differentiation (CDX2) and pluripotency maintenance (NANOG) was not affected (P>0.05) in embryos that reached the morulae and blastocyst stages.ConclusionAlthough the HD embryos that developed to morula and blastocyst stages showed no change in the expression of genes related to their quality and implantation capacity, overall, embryo development was impaired in HD-treated goats.

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