Evidence for a Decreased Noradrenaline Sensitivity in Mesenteric Resistance Vessels from Rats with Chemical Renal Medullectomy

Sj, Bund; Heagerty, AM; Fletcher, A.; Jd, Swales

doi:10.1042/cs0770167

Cited by 3 publications

(1 citation statement)

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“…We have also demonstrated that hypertension induced by chemical renal medullectomy is associated with a reduced NE sensitivity in mesenteric resistance arteries before significant medial growth occurs. 43 In the present experiment, there were no significant differences in media stress between femoral resistance arteries either between strains or between protected and unprotected arteries. Therefore, any differences in active tension or active pressure must be a consequence of altered arterial geometric design.…”

Section: Discussioncontrasting

confidence: 48%

Effects of protection from pressure on resistance artery morphology and reactivity in spontaneously hypertensive and Wistar-Kyoto rats.

Bund

West

Heagerty

1991

Circulation Research

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The effects of regional hypotension on femoral resistance artery reactivity and morphology were investigated in spontaneously hypertensive rats (SHR) and control Wistar-Kyoto (WKY) rats. A partially constricting ligature (0.4 mm i.d.) was placed around the left external iliac artery at 5 weeks, which resulted in significantly reduced femoral mean arterial pressures distal to the ligature at 12 and 24 weeks. The femoral mean arterial pressure distal to the ligature in SHR was similar to that in WKY unprotected hind limbs. Resistance arteries (approximately 200 microns i.d.) were taken from unligatured and protected hind limbs and mounted in a myograph for reactivity and morphological measurements. Each experiment therefore utilized one artery distal to a ligature and one from the control hind limb. Histological examination revealed that nuclear density differed neither between strains nor between arteries from protected and unprotected femoral beds. Media thickness, media cross-sectional area, and media/lumen ratios were reduced in arteries from the hypotensive hind limb in SHR and WKY rats at 12 and 24 weeks. Arteries from the protected hind limbs of SHR were structurally indistinguishable from those from the normally perfused WKY vasculature. It is concluded that the medial content and maximal contractile responses of femoral resistance arteries from SHR and WKY rats are mainly determined by the local perfusion pressure and that normalization of perfusion pressure in SHR normalizes resistance artery structure.

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Section: Discussioncontrasting

confidence: 48%

Effects of protection from pressure on resistance artery morphology and reactivity in spontaneously hypertensive and Wistar-Kyoto rats.

Bund

West

Heagerty

1991

Circulation Research

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Renal Vasodepressor Mechanism: Characterization by Chemical Medullectomy

Swales

Bing

Edmunds

et al. 1988

The American Journal of the Medical Sciences

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Renal and Cardiovascular Effects of Renal Medullary Damage with Bromoethylamine in Dogs

1994

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Bromoethylamine (BEA, 30-40 mg/kg) was administered to dogs to determine whether damage to the inner medulla of the kidney, the putative source of a depressor hormone, causes hypertension in this species. Bromoethylamine produces hypertension in rats but this has not been confirmed in other species, although we have shown that this dose of BEA in dogs abolishes the release of a reno-medullary vasodepressor hormone in response to marked increases in renal perfusion pressure. During acute BEA administration over 1 h to conscious dogs, there were no significant effects on renal blood flow, arterial pressure or total peripheral resistance, but there was a significantly greater diuresis compared to vehicle administration. Over the first 10-14 days after BEA, daily urine output rose 5-10 fold initially and plasma creatinine concentration rose markedly. There was no significant effect on arterial pressure, cardiac output, total peripheral resistance, or renal blood flow over this period. BEA administration caused extensive damage to the thin limbs of the loops of Henle, widespread thrombosis of blood vessels and haemorrhage into the interstitium of the dog renal medulla. Reno-medullary interstitial cells were devoid of lipid droplets, were synthetic, and were associated with increased amounts of extracellular matrix. Thus extensive renal medullary damage by BEA administration to conscious dogs did not alter resting systemic haemodynamics, and these results therefore provide no evidence for a role for the medulla in the maintenance of resting arterial pressure in the dog.

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Evidence for a Decreased Noradrenaline Sensitivity in Mesenteric Resistance Vessels from Rats with Chemical Renal Medullectomy

Cited by 3 publications

References 0 publications

Effects of protection from pressure on resistance artery morphology and reactivity in spontaneously hypertensive and Wistar-Kyoto rats.

Effects of protection from pressure on resistance artery morphology and reactivity in spontaneously hypertensive and Wistar-Kyoto rats.

Renal Vasodepressor Mechanism: Characterization by Chemical Medullectomy

Renal and Cardiovascular Effects of Renal Medullary Damage with Bromoethylamine in Dogs

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