Evidence Excluding Mutations, Polysomy, and Polyploidy as Possible Causes of Non-Mendelian Segregations in Saccharomyces

Mundkur, Balaji D.

doi:10.2307/2394394

Cited by 30 publications

(10 citation statements)

References 8 publications

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“…… The gene‐conversion hypothesis does not lend itself at the present time to critical test, and therefore depends for its validation on the exclusion of other explanations based on known genetic mechanisms … Mundkur273 has demonstrated the inadequacy of the Winge and Roberts410 hypothesis that accounts for these ratios in terms of an extra mitosis in the formation of ascospores … [and] has excluded272 polyploidy as a factor … on the grounds that it will not account for all the irregularities ……”

Section: Lindegren's Controversies With Wingementioning

confidence: 99%

A history of research on yeasts 10: foundations of yeast genetics¹

Barnett

2007

Yeast

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Section: Lindegren's Controversies With Wingementioning

confidence: 99%

A history of research on yeasts 10: foundations of yeast genetics¹

Barnett

2007

Yeast

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“…The term "biomarker" was used for the first time in 1973 to indicate the presence or absence of biological material. However, the concept is older, referenced as a "biochemical marker" in 1949 (12) and "biological marker" in 1957 (13).…”

Section: What Are Biomarkers? Evolution Of Biomarkers Through Historymentioning

confidence: 99%

Biomarkers in Psychiatry: Concept, Definition, Types and Relevance to the Clinical Reality

et al. 2020

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During the last years, an extraordinary effort has been made to identify biomarkers as potential tools for improving prevention, diagnosis, drug response and drug development in psychiatric disorders. Contrary to other diseases, mental illnesses are classified by diagnostic categories with a broad variety list of symptoms. Consequently, patients diagnosed from the same psychiatric illness present a great heterogeneity in their clinical presentation. This fact together with the incomplete knowledge of the neurochemical alterations underlying mental disorders, contribute to the limited efficacy of current pharmacological options. In this respect, the identification of biomarkers in psychiatry is becoming essential to facilitate diagnosis through the developing of markers that allow to stratify groups within the syndrome, which in turn may lead to more focused treatment options. In order to shed light on this issue, this review summarizes the concept and types of biomarkers including an operational definition for therapeutic development. Besides, the advances in this field were summarized and sorted into five categories, which include genetics, transcriptomics, proteomics, metabolomics, and epigenetics. While promising results were achieved, there is a lack of biomarker investigations especially related to treatment response to psychiatric conditions. This review includes a final conclusion remarking the future challenges required to reach the goal of developing valid, reliable and broadly-usable biomarkers for psychiatric disorders and their treatment. The identification of factors predicting treatment response will reduce trial-and-error switches of medications facilitating the discovery of new effective treatments, being a crucial step towards the establishment of greater personalized medicine.

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“…In general, Winkler's theory received little support until Lindegren and his associates (Lindegren, 1949(Lindegren, , 1953Mundkur, 1949 In what follows we will disregard the numerous sources of error which should be considered in tetrad analyses: (s) overlapping of generations, which carries with it a grave risk in the study of yeast genetics, (2) mutation, which here just as in all other organisms can lead to deviations from the expected segregation, (3) adaptation to the ability to ferment certain sugars or to grow in the absence of certain growth substances, which can lead to analytical difficulties, (.) cytoplasmic inheritance of certain respiratory enzymes, which has been shown through the work of Ephrussi (1953) and his associates to exist in yeasts, and () polyploidy, which could easily lead to abnormal segregation, although its occurrence in yeasts has not yet been established with certainty.…”

Section: Introductionmentioning

confidence: 99%