Evidence Based Social Science in China Paper 3: The quality of social science RCTs published from 2000–2020

Li, Xiuxia; Li, Yanfei; Guo, Kangle; Chen, Nan; Cui, Xudong; Zhang, Bai; Chen, Yaolong; Yang, Kehu

doi:10.1016/j.jclinepi.2021.09.014

Cited by 31 publications

(20 citation statements)

References 19 publications

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“…When one item had unclear risk bias, the study was rated as having an unclear risk of bias. When one item was high risk, the study was rated as having a high risk of bias ( Hendarto et al, 2019 ; Luo et al, 2020 ; Li et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis

Shang

Guo²,

Fenfen³

et al. 2022

Front. Pharmacol.

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Objective: A network meta-analysis based on randomized controlled trials was conducted to investigate the effects of pharmacological interventions on smoking cessation.Methods: English databases were searched to obtain randomized controlled trials reporting the effect of pharmacological interventions on smoking cessation. The risk of bias for the included trials was assessed using Cochrane Handbook tool. Stata 15.1 software was used to perform network meta-analysis, and GRADE approach was used to assess the evidence credibility on the effects of different interventions on smoking cessation.Results: A total of 159 studies involving 60,285 smokers were included in the network meta-analysis. The analysis involved 15 interventions and which yielded 105 pairs of comparisons. Network meta-analysis showed that varenicline was more helpful for smoking cessation than other monotherapies, such as nicotine replacement therapy [Odds Ratio (OR) = 1.42, 95% confidence interval (CI) (1.16, 1.73)] and bupropion [OR = 1.52, 95% CI (1.22, 1.89)]. Furthermore, combined interventions were superior to monotherapy in achieving smoking cessation, such as varenicline plus bupropion over bupropion [OR = 2.00, 95% CI (1.11, 3.61)], varenicline plus nicotine replacement therapy over nicotine replacement therapy [OR = 1.84, 95% CI (1.07, 3.18)], and nicotine replacement therapy plus mecamylamine over naltrexone [OR = 6.29, 95% CI (1.59, 24.90)]. Finally, the surface under the cumulative ranking curve value indicated that nicotine replacement therapy plus mecamylamine had the greatest probability of becoming the best intervention.Conclusion: Most pharmacological interventions demonstrated a benefit in smoking cessation compared with placebo, whether monotherapy or combination therapy. Moreover, confirmed evidence suggested that some combination treatments, such as varenicline plus bupropion and nicotine replacement therapy plus mecamylamine have a higher probability of being the best smoking cessation in

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Section: Methodsmentioning

confidence: 99%

Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis

Shang

Guo²,

Fenfen³

et al. 2022

Front. Pharmacol.

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“…The strength of this study was that we used a comprehensive search strategy and included all available published data, thus, increasing the robustness and validity of the results [45]. However, there were some limitations.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Probiotics for preventing gestational diabetes mellitus in overweight or obese pregnant women: A systematic review and meta-analysis

Chu

Yan

Zhang

et al. 2022

Clinical Nutrition ESPEN

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“…Moreover, it is imperative to note that autonomous learning about antimicrobial stewardship in neonatal sepsis through lectures, guidelines and consultations was not substantially correlated with a higher proportion of EI/CI use in our analysis. Consequently, future quality improvement studies or antimicrobial stewardship practices should deliberately arise awareness, optimize processes, and utilize multidisciplinary resources for neonatologists ( Li et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Frontiers in Pharmacology frontiersin.org future quality improvement studies or antimicrobial stewardship practices should deliberately arise awareness, optimize processes, and utilize multidisciplinary resources for neonatologists (Li et al, 2022).…”

Section: Figurementioning

confidence: 99%

The OBTAINS study: A nationwide cross-sectional survey on the implementation of extended or continuous infusion of β-lactams and vancomycin among neonatal sepsis patients in China

et al. 2022

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Background: Dosing strategies of β-lactams and vancomycin should be optimized according to pharmacokinetic/pharmacodynamic principles. However, there is no available data indicating the implementation of extended infusion (EI) or continuous infusion (CI) administration in the management of neonatal sepsis.Methods: A nationwide cross-sectional survey was conducted and the pediatricians from 31 provinces in China were enrolled. A multidisciplinary team created the questionnaire, which had three sections and a total of 21 questions with open- and closed-ended responses. The survey was then conducted using an internet platform in an anonymous way. The data was eventually gathered, compiled, and examined. To identify the risk factors associated with the implementation of EI/CI, logistic regression was carried out.Results: A total of 1501 respondents answered the questionnaires. The implementation of EI/CI of β-lactams and vancomycin were only available to one-third of the respondents, and the prolonged strategy was primarily supported by guidelines (71.25%) and advice from medical specialists (55.18%). A significant fraction (72.94%–94.71%) lacked a strong understanding of the infusions’ stability. Additionally, it was discovered that more frequent MDT discussions about antibiotic use and the appropriate time pediatricians worked in the neonatal ward were associated with an increase in the use of the EI/CI strategy.Conclusion: The EI/CI strategy in neonatal sepsis was not well recognized in China, and it is necessary to establish a solid MDT team with regularly collaborates. In the near future, guidelines regarding prolonged infusion management in neonatal sepsis should be developed.

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Evidence Based Social Science in China Paper 3: The quality of social science RCTs published from 2000–2020

Cited by 31 publications

References 19 publications

Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis

Pharmacological interventions on smoking cessation: A systematic review and network meta-analysis

Probiotics for preventing gestational diabetes mellitus in overweight or obese pregnant women: A systematic review and meta-analysis

The OBTAINS study: A nationwide cross-sectional survey on the implementation of extended or continuous infusion of β-lactams and vancomycin among neonatal sepsis patients in China

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