Evidence-Based and Patient-Oriented Inositol Treatment in Polycystic Ovary Syndrome: Changing the Perspective of the Disease

Laganà, Antonio Simone; Rossetti, Paola; Sapia, Fabrizio; Chiofalo, Benito; Buscema, Massimo; Valenti, Gaetano; Rapisarda, Agnese Maria Chiara; Vitale, Salvatore Giovanni

doi:10.5812/ijem.43695

Cited by 63 publications

(50 citation statements)

References 10 publications

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“…Besides, some specific reproductive conditions, such as polycystic ovary syndrome (PCOS), are associated with insulin resistance 52 and secondary hyperandrogenism 53 . Lagana and his colleagues also found that insulin sensitizers could improve the PCOS symptoms 54 , which hints that additional RFs could benefit the chronic conditions screening. In sum, despite the fact that the relationship between RFs and chronic conditions could not be interpreted by a single factor, RFs do have strong associations with chronic conditions.…”

Section: Discussionmentioning

confidence: 91%

Screening for chronic conditions with reproductive factors using a machine learning based approach

Tian

Dong

Chan

et al. 2020

Sci Rep

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A large proportion of cases with chronic conditions including diabetes or pre-diabetes, hypertension and dyslipidemia remain undiagnosed. to include reproductive factors (Rf) might be able to improve current screening guidelines by providing extra effectiveness. The objective is to study the relationships between Rfs and chronic conditions' biomarkers. A cross-sectional study was conducted. Demographics, RFs and metabolic biomarkers were collected. The relationship of the metabolic biomarkers were shown by correlation analysis. principal component analysis (pcA) and autoencoder were compared by cross-validation. The better one was adopted to extract a single marker, the general chronic condition (GCC), to represent the body's chronic conditions. Multivariate linear regression was performed to explore the relationship between GCC and RFs. In total, 1,656 postmenopausal females were included. A multi-layer autoencoder outperformed pcA in the dimensionality reduction performance. The extracted variable by autoencoder, GCC, was verified to be representative of three chronic conditions (AUC for patoglycemia, hypertension and dyslipidemia were 0.844, 0.824 and 0.805 respectively). Linear regression showed that earlier age at menarche (OR = 0.9976) and shorter reproductive life span (oR = 0.9895) were associated with higher GCC. Autoencoder performed well in the dimensionality reduction of clinical metabolic biomarkers. Due to high accessibility and effectiveness, RFs have potential to be included in screening tools for general chronic conditions and could enhance current screening guidelines.

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Section: Discussionmentioning

confidence: 91%

Screening for chronic conditions with reproductive factors using a machine learning based approach

Tian

Dong

Chan

et al. 2020

Sci Rep

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“…Interestingly, oxidative stress is linked to both abnormally elevated T level and insulin resistance (Rani, Deep, Singh, Palle, & Yadav, ; Reyes‐Muñoz et al., ). In recent years, insulin sensitizer drugs such as inositol isoforms have drawn increasing attention owing to their safety profile and key role in modulating secondary messenger activity in insulin signal transduction pathways (Laganà et al., ). Oxidative stress develops as a consequence of an imbalance between the generation of free radicals and the scavenging capacity of antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Hydroxysafflor yellow A exerts beneficial effects by restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice

Luo

Huang

Yang

et al. 2020

Experimental Physiology

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Polycystic ovary syndrome (PCOS) is the most common endocrine disease resulting in female infertility. Hydroxysafflor yellow A (HSYA) and ginsenoside Rb1 have been shown to have antioxidant properties, but little is known about their impact in PCOS. Here dehydroepiandrosterone was used to induce PCOS in a mouse model that was characterized by an irregular oestrous cycle, cystic follicles and an elevated serum testosterone level. Supplementation of HSYA restored the oestrous cycle of PCOS mice, reduced follicular cysts in PCOS mouse ovaries and brought about a decline in serum testosterone level, while ginsenoside Rb1 did not ameliorate the above symptoms of PCOS mice. After HSYA treatment, there was elevation of serum oestradiol, progesterone, luteinizing hormone and anti-Müllerian hormone levels and a reduction of follicle-stimulating hormone level, but ginsenoside Rb1 only rescued the levels of follicle-stimulating hormone and anti-Müllerian hormone. Further analysis evidenced that HSYA reversed the expression of steroid hormone secretion-related genes Star, Hsd3b1, Cyp11a1 and Cyp19a1. In PCOS mice HSYA weakened the elevation of ovarian malondialdehyde, which is regarded as a biomarker for oxidative stress. Moreover, HSYA improved reduced glutathione content accompanied by a simultaneous increase in reduced to oxidized glutathione ratio, and enhanced the activities of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and catalase. Collectively, HSYA exerted beneficial effects on PCOS mice by restoring hormone secretion and alleviating oxidative stress.

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“…In addition, although the sample size of this study is larger than that of the previous studies (14,15), the sample size is still relatively small considering the incidence of precocious puberty. The clinical manifestations of polycystic ovary syndrome (PCOS) patients mostly start in puberty and the main clinical features are particularly similar to physiological changes in puberty, such as insulin resistance (30,31). CPP has been shown to be the rst appearance of PCOS (32).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Pituitary Volume in Girls with Precocious Puberty

Yang

Wang

et al. 2020

Preprint

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Background: To date, the gonadotropin-releasing hormone (GnRH) stimulation test is still the gold standard for precocious puberty (PP) diagnosis. However, it has many disadvantages, including low sensitivity, high cost, and invasive operation. This study aims to evaluate whether magnetic resonance imaging (MRI)-derived variables, including pituitary volume (PV), could be used as diagnostic factors for PP in girls, providing a non-invasive diagnostic approach for PP.Methods: A total of 288 young female patients who presented to the Clinic of Pediatric Endocrinology for evaluation of PP from January 2015 to December 2017 were enrolled. The sample included 90 girls diagnosed with premature thelarche (PT), 133 girls determined as idiopathic central precocious puberty (ICPP), 35 early pubertal girls, and 30 normal girls. All patients received pituitary MRI examinations.Results: The largest PV and pituitary height were shown in the ICPP and pubertal groups, followed by the PT group. The receiver operating characteristic (ROC) curve analysis showed that PV is a predictive marker for ICPP, with a sensitivity of 54.10% and a specificity of 72.20% at the cutoff value of 196.01 mm3. By univariate analysis, PV was positively associated with peak luteinizing hormone (LH), LH/follicle-stimulating hormone (FSH), age, bone age, and body mass index (BMI) (all P < 0.05). However, bone age and peak LH were the only significant predictors of PV as demonstrated by the stepwise multivariate regression analysis (Model: PV = 9.431 * bone age + 1.230 * peak LH + 92.625 [P = 0.000, R2 = 0.159]).Conclusions: The PV in the ICPP group was significantly higher than in PT and control groups, but there was no reliable cutoff value to distinguish ICPP from PT. Pituitary MRI should be combined with clinical and laboratory tests to improve the diagnostic value of PV for PP.

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Evidence-Based and Patient-Oriented Inositol Treatment in Polycystic Ovary Syndrome: Changing the Perspective of the Disease

Cited by 63 publications

References 10 publications

Screening for chronic conditions with reproductive factors using a machine learning based approach

Screening for chronic conditions with reproductive factors using a machine learning based approach

Hydroxysafflor yellow A exerts beneficial effects by restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice

Diagnostic Value of Pituitary Volume in Girls with Precocious Puberty

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