Evere Multisystem Craniocerebral Injury: Features of the Clinical Course and Outcomes

Шабанов, А. К.; Kartavenko, V. I.; Петриков, С. С.; Марутян, З. Г.; Розумный, П. А.; Черненькая, Т. В.; Папышев, И. П.; Talypov, Aleksandr; Vladimirova, E S; Кузовлев, А. Н.

doi:10.23934/2223-9022-2017-6-4-324-330

Neotložnaâ med. pomoŝʹ

2017

DOI: 10.23934/2223-9022-2017-6-4-324-330

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Evere Multisystem Craniocerebral Injury: Features of the Clinical Course and Outcomes

А. К. Шабанов¹,

V. I. Kartavenko²,

С. С. Петриков³

et al.

Abstract: АД ср-среднее артериальное давление ДТП-дорожно-транспортное происшествие ИВЛ-искусственная вентиляция легких ИЛО-инфекционные легочные осложнения ОРИТ-отделение реанимации и интенсивной терапии ТСТ-тяжелая сочетанная травма тяжелая соЧетаННая ЧеРепНо-моЗГоВая тРаВма: осоБеННости клиНиЧескоГо теЧеНия и исХоды а ано 1 В арта енко 1 Петрико 1 арутян 1 П озумн 2 В ернен кая 1 П Пап е 2 ал по 1 Владимиро а 1 узо ле 3 1 ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы», Москва,… Show more

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Cited by 5 publications

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Experience in the surgical tactics of complex treatment of victims with severe combined trauma

Gnoevyh

Manohin

Кукош

et al. 2022

vmirvz

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Relevance. Currently, there is an increase in combined injuries worldwide, with more than a third of the victims of this category dying from various complications in the post-traumatic period.Objective: To determine the possibility of performing optimal surgical interventions in patients with multiple and combined trauma, including anti-shock, with shock of varying duration against the background of intensive therapy.Research material. The paper analyzes the surgical tactics of complex treatment of 150 victims with severe combined trauma. In the course of the study, we divided them into five clinical groups with various shock phenomena. Prediction and determination of the expected duration of shock against the background of intensive therapy was carried out using the table "Score assessment of shockogenicity of trauma" and nomograms developed at the I.I. Janelidze. Research Institute of Emergency Medicine.The results of the work. For clinical and prognostic groups, we noted a correlative relationship between the predicted duration of shock and the time of possible recovery operations, as a result, the coefficient of multiplicity of recovery was revealed. Dividing the average bed-day in hours by the duration of the shock in the forecast groups, we calculated the coefficient of multiplicity "K", which averaged 11 days. K= (144:12 + 184:18 +224:25) : 3 ≈ 11 ( days).Conclusions. Predicting the duration of shock allowed us to develop in an experiment and propose for implementation into clinical practice sparing surgical interventions that are of the nature of anti-shock, as well as to determine the most optimal time for performing reconstructive operations on the principle of simultaneous polysegmental osteosynthesis: 1. Operations for damage to the organs of the upper and lower floors of the abdominal cavity and pelvis. 2. Primary stabilization of fractures of the pelvic bones by an external fixation device in our modification. 3. Fixation of floating rib plastrons by the external fixation device of our modification. 4. Simultaneous polysegmental osteosynthesis.

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Experience in the surgical tactics of complex treatment of victims with severe combined trauma

Gnoevyh

Manohin

Кукош

et al. 2022

vmirvz

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Neuroprotective Properties of Xenon According to Experimental Studies

Гребенчиков

Molchanov

Shpichko

et al. 2020

Neotložnaâ med. pomoŝʹ

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ABSTRACT. An increase in the number of patients with severe brain damage of various etiologies determines the need to improve neuroprotection technologies. The review is devoted to modern views on the mechanisms of brain protection, as well as the basic processes underlying damage to neurons. The article discusses the results of the most important experimental studies in this area using inert xenon gas. The authors analyzed a number of works highlighting neurotective properties of the xenon inhalation anesthetic in studies performed in vitro and in vivo. The main mechanisms of neuronal death depending on the type of damage are shown, the points of application of the protective effect of xenon on the brain and the prospects for further research in this area are demonstrated in the article.

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Effect of Xenon on the Phosphorylation of Glycogen Synthase Kinase 3β and Antioxidant Enzymes in Rat Brain

Кузовлев

Shpichko

Рыжков

et al. 2021

Neotložnaâ med. pomoŝʹ

Self Cite

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Relevance. The increase in the number of severe brain injuries due to stroke and traumatic brain injury determines the need to study and develop effective strategies for neuroprotection. The article highlights new mechanisms of the neuroprotective action of the inhalation anesthetic xenon based on the data of our own experimental studies.Aim of study. To assess the effect of anesthesia with xenon at a concentration of 0.5 MAC (minimum alveolar concentration) on the phosphorylation of glycogen synthase kinase 3β (GSK-3β) and the content of antioxidant defense enzymes in the rat brain.Material and methods. The effect of inhalation anesthesia with xenon on the phosphorylation of the GSK-3β enzyme in comparison with lithium chloride, as well as on the content of heme oxygenase, catalase, and Mn-superoxide dismutase in rat brain homogenates was studied by immunoblotting.Results. The use of xenon at a concentration of 0.5 MAA causes an almost twofold increase in the content of the phosphorylated form of the GSK-3β enzyme in comparison with the control (p<0.05) and significantly increases the pool of antioxidant defense enzymes: heme oxygenase by 50% (p <0.05) and Mn-superoxide dismutase by 60% (p<0.05).Conclusion. The conducted experimental study revealed new molecular mechanisms of action of the inhalation anesthetic xenon. The effect of xenon on the pool of enzymes involved in the protection of the brain from oxidative distress was found. The data obtained indicate the prospects for using xenon and require further research in this direction. The use of xenon at a concentration of 50 vol.% (0.5 MAA) for 30 minutes does not affect the content of the glycogen synthase-3β enzyme, at the same time causing an almost twofold increase in its phosphorylated form, the glycogen synthase-3β enzyme, and is accompanied by a significant increase the content of heme oxygenase, Mn-superoxide dismutase and a slight increase in the content of catalase in rat brain homogenates. Thus, the results of the study suggest that one of the possible mechanisms of the neuroprotective effect of xenon is the phosphorylation of glycogen synthase-3β, which prevents the opening of the mitochondrial pore, inhibiting the death of mitochondria-mediated apoptosis of neurons and increasing the level of antioxidant protection in them.

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Evere Multisystem Craniocerebral Injury: Features of the Clinical Course and Outcomes

Cited by 5 publications

References 1 publication

Experience in the surgical tactics of complex treatment of victims with severe combined trauma

Experience in the surgical tactics of complex treatment of victims with severe combined trauma

Neuroprotective Properties of Xenon According to Experimental Studies

Effect of Xenon on the Phosphorylation of Glycogen Synthase Kinase 3β and Antioxidant Enzymes in Rat Brain

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