Eventos cardiovasculares: um efeito de classe dos inibidores de COX-2

Araujo, Leila Fernandes; Soeiro, Alexandre de Matos; Fernandes, Juliano de Lara; Júnior, Carlos Vicente Serrano

doi:10.1590/s0066-782x2005001600016

Cited by 17 publications

(22 citation statements)

References 35 publications

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“…However, studies have shown that COX-1 is present in conjunction with COX-2 at sites of inflammation, while COX-2 can be expressed constitutively 4 in certain areas of the kidney, brain and endothelial cells for normal physiological functions 5 .…”

Section: Most Of Nsaids Collateral Effects Are Attributed Tomentioning

confidence: 99%

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

et al. 2013

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PURPOSE:To evaluate the renal function in healthy dogs submitted to nonselective and preferential COX-2 nonsteroidal antiinflammatory drug (NSAID) therapy. METHODS:Twenty four healthy dogs were distributed into four groups (G) (n=6): ketoprofenG -treated with ketoprofen; nimesulideG -treated with nimesulid; meloxicanG -treated with meloxican; and etodolacG -treated with etodolaco. All the dogs received the NSAIDs for 10 days by oral route. Physical examination and renal function (urinalysis, urinary sodium and gamma-glutamyl transpeptidase (GGT), serum urea, creatinine, potassium and sodium, and endogenous creatinine clearance) were evaluated before, after five and ten days (T0, T5 and T10) of the treatment in all groups. RESULTS:Changes were observed in urinalysis, with a significant increase in renal cells in the urine at T5 and T10 in nimesulideG.Significant reduction in urinary sodium in nimesulideG at T5 was observed. The clearance values were lower in ketoprofenG at T10. CONCLUSIONS:Meloxicam and etodolac were the drugs that have proven to be safer for short-term therapy in healthy dogs in relation to renal function. NSAIDs ketoprofen and nimesulide should be used judiciously in dogs with renal dysfunction, since there are promoted changes in renal function.

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Section: Most Of Nsaids Collateral Effects Are Attributed Tomentioning

confidence: 99%

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

et al. 2013

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“…Therefore, drugs have been shown to be effective with regard to inhibition of the cascade of inflammatory events. However, they are delivered systemically, which may interfere with the normal functioning of other tissues and processes [17,18]. On the other hand, low-level laser therapy has been reported to be an important noninvasive agent which might achieve the same results as drugs without triggering secondary effects [38].…”

Section: Discussionmentioning

confidence: 99%

“…Nonsteroidal antiinflammatory drugs are a drug class which is widely used in the treatment of postoperative pain, osteoarthritis and rheumatoid arthritis, among other conditions. Their main effects are antiinflammatory, analgesic and antipyretic, and in general their action is associated with the inhibition of cyclooxygenase enzyme, which has two isoforms, cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) [17]. COX-1 is expressed constitutively in all body tissues.…”

Section: Introductionmentioning

confidence: 99%

Low-level laser irradiation, cyclooxygenase-2 (COX-2) expression and necrosis of random skin flaps in rats

et al. 2011

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Skin flaps are still a matter of concern among surgeons, as failures can occur leading to flap necrosis. However, low-level laser irradiation has been reported as an effective tool to improve the viability of ischemic flaps, yet its mechanisms of action remain unclear. We investigated the effect of low-level laser irradiation on the viability of random skin flaps in rats and determined COX-2 expression in the flap pedicle. The study animals comprised 24 EPM-1 Wistar rats which were randomly allocated into three equal groups. A cranially based dorsal random skin flap measuring 10 × 4 cm was created in all the animals. In one group, laser irradiation was simulated (sham group), and in the other two groups the animals were irradiated at 12 points with 0.29 J at 20 mW (energy density 10.36 J/cm(2), irradiance 0.71 W/cm(2)), or with 7.3 J at 100 mW (energy density 260.7 J/cm(2), irradiance 3.57 W/cm(2)). These procedures were applied to the cranial half of the flap immediately after surgery and were repeated on days 2 and 5 after surgery. The percentage necrotic area was determined on day 7 after surgery by the paper template method. The immunohistochemical expression of COX-2 in the samples was given scores from 0 to 3. The necrotic area was smaller in group irradiated at 7.3 J compared to sham-treated group and to the group irradiated at 0.29 J (P < 0.05); there was no difference between the sham-treated group and group irradiated at 0.29 J. COX-2 expression was lower in the group irradiated at 7.3 J than in the sham-treated group and the group irradiated at 0.29 J (P < 0.001). Low-level laser therapy was effective in decreasing random skin flap necrosis in rats using a laser energy of 7.30 J per point. Laser irradiation also decreased the expression of COX-2 in the flap pedicle.

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“…The NSAID also act as analgesic and as antipyretic. The basic action of this medicament occurs with the inhibition of the cycloxigenase enzyme (COX) which acts as a catalyzer of the conversion reaction from arachidonic acid into prostaglandins (PG's) and thromboxanes (TX's) 3 .…”

Section: Introductionmentioning

confidence: 99%

“…Although they had an anti-inflammatory efficiency, the first NSAID developed showed an increase in gastrointestinal symptoms and were, therefore, not indicated for chronical use 3 .…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular and hematologic effects produced by chronic treatment with etoricoxib in normotensive rats

Baracho¹,

Guizelli²,

Carmello³

et al. 2009

Acta Cir. Bras.

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Eventos cardiovasculares: um efeito de classe dos inibidores de COX-2

Cited by 17 publications

References 35 publications

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

Low-level laser irradiation, cyclooxygenase-2 (COX-2) expression and necrosis of random skin flaps in rats

Cardiovascular and hematologic effects produced by chronic treatment with etoricoxib in normotensive rats

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