Event-Related Potentials Study in Children with Borderline Intellectual Functioning

Vaney, Neelam; Khaliq, Farah; Anjana, Yumnam

doi:10.4103/0253-7176.150820

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…P300 and P2 reached the highest amplitudes in the average-intelligence group. This result is consistent with previous findings (Vaney et al, 2015) and may be explained by the type of cognitive task that is employed (Amin et al, 2015; McGarry-Roberts et al, 1992; Zhang et al, 1989). The task did not rely on great perceptual or discriminant ability.…”

Section: Discussionsupporting

confidence: 93%

“…However, several others have reported a negative or no correlation between P300 amplitude and individual differences in intelligence (Houlihan, Stelmack, & Campbell, 1998; McGarry-Roberts, Stelmack, & Campbell, 1992; Robaey, Cansino, Dugas, & Renault, 1995). Vaney, Khaliq, and Anjana (2015) used a simple auditory oddball task and recorded ERPs in medium- and low-intelligence groups of children. They found lower P2 amplitudes in the more intelligent group and no significant differences in P300.…”

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confidence: 99%

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Event-related potentials and intelligence among Brazilian schoolchildren: An exploratory study.

Schlottfeldt¹,

Mansur‐Alves²,

Flores-Mendoza³

et al. 2018

Psychology & Neuroscience

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Intelligence is a complex behavioral phenomenon, the biological substrates for which require further investigation. The present study investigated differences in electroencephalographic patterns of P300 waves between average- and high-intelligence Brazilian children using a cognitive working memory task. Brain activity was recorded in 8 children (Mage = 11.2 years, SD = .40 years) while they performed a working memory task. Four children had an IQ >120 (high-IQ group), and 4 had an IQ between 90 and 110 (average-IQ group). Different event-related potential (ERP) components were analyzed. The latency and amplitude of these wave peaks were analyzed by repeated-measures analysis of variance. The groups differed in reaction time but not in the level of accuracy of their responses. With regard to ERPs, we observed an effect of intelligence on P3 latency, the difference for which reached the greatest magnitude, but this effect was only marginally significant (p = .098). Differences in the amplitudes of P2 and P3 were not significant between groups. Likewise, the more intelligent children were more likely to respond to the behavioral task more quickly. They also had a lower latency of the later components of ERPs. Although the results were only marginally significant, they are consistent with previous studies in this field.

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Event-related potentials and intelligence among Brazilian schoolchildren: An exploratory study.

Schlottfeldt¹,

Mansur‐Alves²,

Flores-Mendoza³

et al. 2018

Psychology & Neuroscience

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“…It is thought that they may lag one to two years behind their peers of average intelligence. This may be due to impaired information processing which has an important role in the development of mental ability (Vaney et al, 2015). The authors, studied event-related potential, a non-invasive method, to study brain response to a variety of cognitive events, e.g.…”

Section: Neurodevelopment and Educationmentioning

confidence: 99%

Borderline intellectual functioning and neurodevelopmental disorders: prevalence, comorbidities and treatment approaches

Hassiotis¹

2015

Advances in Mental Health and Intellectual Disabilities

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Purpose – The purpose of this paper is to provide a synthesis of the literature on the topic of developmental framework and health comorbidities of children and adults with borderline intellectual functioning (BIF) and neurodevelopmental disorders. Design/methodology/approach – A rapid review of the literature and hand searching of relevant papers from 1999 to 2015 was carried out. Totally, 21 papers were identified covering a range of perspectives from neurodevelopmental trajectories to prevalence, treatment and service use. Findings – All papers were utilised and complemented a previous review which, however, had not covered the aspect of treatment approaches for this population. As a group they appear to have distinctly different profiles from people with mild intellectual disability and of peers with average intelligence. Practical implications – The evidence summary indicates an ongoing interest by the international scientific community in the topic of BIF. This group are often lost in the health system and may not receive appropriate care given their unique clinical profile. More should be done to increase clinicians’ awareness of their health needs. Originality/value – The paper adds substantially to a previous review of the topic. An international collaboration may help to increase the profile of this work and lead to further changes in the care these individuals receive across the diagnostic and treatment spectrum.

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“…In normal aging, age-related amplitude reduction, latency prolongation, and topographically more frontally oriented P300 have been consistently reported across studies [ 22 ]. Decreases in P300 amplitude and increases in latency more severe than those in normal aging have been reported in patients with dementia, psychiatric disorders, alcohol dependence, and traumatic brain injury (TBI), and in neurodevelopmental disorders [ 23 – 25 ]. The utility of the P300 latency as an objective measure in detecting changes in the cognitive performance for the application of testing therapeutics developed for neurodegenerative and neuropsychiatric disorders with associated cognitive deficits is discussed further in Section 5 .…”

Section: Event-related Potentials (Erps)mentioning

confidence: 99%

“…Meador and colleagues' study had a large influence on clinical practice when it demonstrated prolonging of P300 latency with antiepileptic drugs [ 93 ]. Indeed, the prolonged P300 latency has also been demonstrated in other indications with working memory deficits, including HD [ 26 ], transient ischemic stroke [ 94 ], intellectual disability [ 25 ], attention deficit hyperactivity disorder [ 95 ], and sleep deprivation [ 96 , 97 ]. Additionally, evaluation of ERP P300 in patients with TBI demonstrated increased P300 latency and reduced amplitude compared with healthy controls [ 24 , 98 ].…”

Section: Erp In Dementiamentioning

confidence: 99%

Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential

et al. 2022

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Neurodegenerative diseases, such as Alzheimer’s disease (AD), and their associated deterioration of cognitive function are common causes of disability. The slowly developing pathology of neurodegenerative diseases necessitates early diagnosis and monitored long-term treatment. Lack of effective therapies coupled with an improved rate of early diagnosis in our aging population have created an urgent need for the development of novel drugs, as well as the need for reliable biomarkers for treatment response. These issues are especially relevant for AD, in which the rate of clinical trial drug failures has been very high. Frequently used biomarker evaluation procedures, such as positron emission tomography or cerebrospinal fluid measurements of phospho-tau and amyloid beta, are invasive and costly, and not universally available or accessible. This review considers the functionality of the event-related potential (ERP) P300 methodology as a surrogate biomarker for predicting the procognitive potential of drugs in clinical development for neurocognitive disorders. Through the application of standardized electroencephalography (EEG) described here, ERP P300 can be reliably measured. The P300 waveform objectively measures large-scale neuronal network functioning and working memory processes. Increased ERP P300 latency has been reported throughout the literature in disorders of cognition, supporting the potential utility of ERP P300 as a biomarker in many neurological and neuropsychiatric disorders, including AD. Specifically, evidence presented here supports ERP P300 latency as a quantitative, unbiased measure for detecting changes in cognition in patients with AD dementia through the progression from mild to moderate cognitive impairment and after drug treatment.

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Event-Related Potentials Study in Children with Borderline Intellectual Functioning

Cited by 5 publications

References 18 publications

Event-related potentials and intelligence among Brazilian schoolchildren: An exploratory study.

Event-related potentials and intelligence among Brazilian schoolchildren: An exploratory study.

Borderline intellectual functioning and neurodevelopmental disorders: prevalence, comorbidities and treatment approaches

Predictive Power of Cognitive Biomarkers in Neurodegenerative Disease Drug Development: Utility of the P300 Event-Related Potential

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