Event-related potentials in Parkinsonian patients under auditory discrimination tasks

Brain Event - Related Oscillations in Parkinsonian Patients During Discrimination Task Conditions

“…Many authors agree that the main power of P300 is in the delta range (Demiralp et al, 1999;Karakas et al, 2000;Klimesch et al, 2000;Klimesch et al, 2006). The lower -ERS in PP in the late post-stimulus period, which becomes -ERD in some recordings, could explain the lower P3 amplitude observed in PP (Philipova et al, 1997). Our patients were medicated by L-dopa drugs and this medication may have had some effect on the present findings.…”

“…Many electroencephalographic (EEG) studies on PD have used the event-related potential (ERP) method, where the early modal dependent and obligatory N1 and P2 components permit analysis of sensory events while the later N2 and P3 potentials reflect the cognitive processes involving the assessment of stimuli, decision making, strategy selection and recognition memory. ERP investigations have shown P3 predominantly with prolonged latencies and/or diminished amplitudes for Parkinsonian patients (PP) when compared to healthy subjects (HS) (Evarts et al, 1981;Tachibana et al, 1992;Philipova et al, 1997;Wascher et al, 1997;Minamoto et al, 2001;Antal et al, 2002;Wang et al, 2002). Such results have been interpreted as electrophysiological signs of cognitive slowing with respect to stimulus classification and attentional processing (Robertson & Empson, 1999).…”

Event-Related Potential and EEG Measures in Parkinson’s Disease without and with Dementia

“…Lagopoulos et al [16] found no difference of P3 amplitude in PD patients compared with controls; disease duration was around 5 years, but cognitive functioning of the declaredly nondemented patients was not tested. Philipova et al [13] and Raudino et al [12] found decreased P3 amplitude in nondemented PD patients. Philipova et al [13] Tanaka/Koenig/Pascual-Marqui/Hirata/ Kochi/Lehmann intellectual assessment, but their patients showed poor task performance compared with controls.…”

“…Philipova et al [13] and Raudino et al [12] found decreased P3 amplitude in nondemented PD patients. Philipova et al [13] Tanaka/Koenig/Pascual-Marqui/Hirata/ Kochi/Lehmann intellectual assessment, but their patients showed poor task performance compared with controls. Raudino et al [12] did not report age, duration, and severity of disease of their nondemented patients; for demented PD patients (the only such study we are aware of), they reported further decrease in P3 amplitude.…”

“…In several studies on nondemented PD patients, P3 latency did not differ from the norm [9][10][11], but there was no agreement on P3 amplitude deviations in these nondemented patients: compared to normals, some [12,13] found a decrease, others [14][15][16] no difference; on the other hand, the extensive study by Green et al [17] reported an unexpected increase in P3 amplitude.…”