Brain Event - Related Oscillations in Parkinsonian Patients During Discrimination Task Conditions

Dushanova, Juliana

doi:10.5772/19937

Cited by 4 publications

(5 citation statements)

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“…This effect was most prominent over the frontal and central scalp areas (Tiitinen et al 1993). During cognitive processing, γ1 oscillations were further linked to mechanisms of sensory information matching with memory contents (Kaiser et al 2009a, 2009b, Dushanova 2011, acquisition and retention of relevant stimulus features in memory Basar 1998, Dushanova 2011), and to post-discrimination processes related to the late cognitive P3 wave (Basar et al 1993). Greater γ1 decrease in the elderly group could reflect less efficiency in a spatially localized gamma-band network specifically involved in auditory short-term memory to attain mental representation of the specific tone stimulation in order to correct tone discrimination and avoid wrong hand reaction and this process could be affected by age (Kaiser et al, 2009a(Kaiser et al, , 2009b.…”

Section: The Age Reduced the Cognitive Processesmentioning

confidence: 99%

“…Gamma frequency activity has been linked to a variety of perceptual and cognitive functions such as feature binding, selective attention , Fell et al 2003, Tiitinen et al 1993, Kukleta et al 2010. Alterations in gamma band activity have also been related to pathological processes (Llinas et al 1999, Dushanova 2011. Spectral domain development studies have shown reduced low-frequency density and increased high-frequency density with age (Thatcher 1992, Lippe et al 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Dementia occurs in several major neurodegenerative disorders, such as fronto-temporal dementia and hippocampal sclerosis of aging, Alzheimer's disease, and Lewy body dementia, which vary between brain regions such as the hippocampus, entorhinal cortex, medial temporal lobe, frontal cortex and inferior parietal cortex, and may explain a magnitude of deficits in different cognitive domains. Specific frequency oscillations that occur within the affected brain regions have been used to classify some idiopathic dementias as specific diseases (Dushanova 2011).…”

Section: Introductionmentioning

confidence: 99%

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Functional correlates of brain aging: beta and gamma components of event-related band responses

Christov¹,

Dushanova²

2016

Acta Neurobiologiae Experimentalis

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The brain as a system with gradually declining resources by age maximizes its performance by neural network reorganization for greater efficiency of neuronal processes which is reflected in changes of event-related band responses (ERBRs) for sensory stimuli. Whether changes of high-frequency components of event-related responses are related to plasticity in neural recruitment during stabilization of sensory/cognitive mechanisms accompanying aging or are underlying pathological changes remains unknown.The effect of aging on beta (β1: 12.5-20; β2: 20.5-30 Hz) and gamma (γ1: 30.5-49; γ2: 52-69 Hz) band components of ERP was studied in an auditory discrimination task (low-frequency and high-frequency tone) at frontal, central, parietal and occipital cortical locations at short latency (post-stimulus interval 0-250 ms; putative sensory processing) and long latency (250-600 ms; putative cognitive) periods.Beta1 component of the short latency period of ERBRs was less affected by age. The beta1 activity of the long latency period was reduced by age and more widespread than in the short latency period. The aged difference in beta1 component spread into fronto-parietal regions and was more expressed after high-frequency than after low tone stimulation. Beta2 and gamma amplitudes were higher with progressive age during sensory processing. Reducing regional-process specificity with progressing age characterized tone-dependent beta2 changes during short latency (sensory), but not during long latency (cognitive) processing. Late latency (cognitive) beta2 and gamma activity diminished with age, except for the frontal high tone responses. With increasing age, gamma2 activity was more expressed over the frontal brain areas in high tone discrimination.We concluded that age influenced more the long latency (cognitive) processes than the short latency (sensory) ones.

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Section: The Age Reduced the Cognitive Processesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional correlates of brain aging: beta and gamma components of event-related band responses

Christov¹,

Dushanova²

2016

Acta Neurobiologiae Experimentalis

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“…Disruptions of spontaneous speech are also captured in PD. The spontaneous speech of patients with PD is less fluent, monotonous, and syntactically simpler with a disturbance in the informativeness present 51 . In recent years, attention has also been paid to cohesion and coherence in early PD.…”

Section: Methodsmentioning

confidence: 99%

EWA-DB, Slovak Database of Speech Affected by Neurodegenerative Diseases

Rusko,

Sabo,

Trnka

et al. 2023

Preprint

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A new Slovak speech database EWA-DB was created for research purposes aimed at early detection of neurodegenerative diseases from speech. It contains 1649 speakers performing various speech and language tasks, such as sustained vowel phonation, diadochokinesis, naming and picture description. The sample of speakers consists of individuals with Alzheimer’s disease, mild cognitive impairment, Parkinson’s disease, and healthy controls. In this article we describe the EWA-DB development process, the language and speech task selection, patient and healthy control recruitment, as well as the testing and recording protocol. The structure and content of the database and file formats are described in detail. We assume that the presented database could be suitable for the development of automatic systems predicting the diagnoses of Alzheimer’s disease, mild cognitive impairment, and Parkinson’s disease from language and speech features.

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“…However, it can be hypothesized that an increase in auditory processing load, for example by using a high stimulus rate, complex signals such as speech, or noise-added conditions could result in other insights (De Groote et al, 2020;Schwent et al 1976a, Schwent et al 1976bTalsma et al 2010). Third, research into sensory and cognitive processing in PD has been characterized by dysfunctions in various oscillatory networks (Dushanova et al 2009, Dushanova et al 2010Dushanova 2011;Güdücü et al 2019;Güntekin et al 2018;Solís-Vivanco et al 2018). Frequency or joint time-frequency analysis (Zhang 2019) may provide valuable insights into the spectral power changes that are associated with auditory processing in patients with PD.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Neurophysiological investigation of auditory intensity dependence in patients with Parkinson’s disease

et al. 2021

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There is accumulating evidence for auditory dysfunctions in patients with Parkinson's disease (PD). Moreover, a possible relationship has been suggested between altered auditory intensity processing and the hypophonic speech characteristics in PD. Nonetheless, further insight into the neurophysiological correlates of auditory intensity processing in patients with PD is needed primarily.In the present study, high-density EEG recordings were used to investigate intensity dependence of auditory evoked potentials (IDAEPs) in 14 patients with PD and 14 age-and gendermatched healthy control participants (HCs). Patients with PD were evaluated in both the on-and offmedication states. HCs were also evaluated twice.Significantly increased IDAEP of the N1/P2 was demonstrated in patients with PD evaluated in the on-medication state compared to HCs. Distinctive results were found for the N1 and P2 component. Regarding the N1 component, no differences in latency or amplitude were shown between patients with PD and HCs regardless of the medication state. In contrast, increased P2 amplitude was demonstrated in patients with PD evaluated in the on-medication state compared to the off-medication state and HCs.In addition to a dopaminergic deficiency, deficits in serotonergic neurotransmission in PD were shown based on increased IDAEP. Due to specific alterations of the N1-P2 complex, the current results suggest deficiencies in early-attentive inhibitory processing of auditory input in PD. This interpretation is consistent with the involvement of the basal ganglia and the role of dopaminergic and serotonergic neurotransmission in auditory gating.

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Brain Event - Related Oscillations in Parkinsonian Patients During Discrimination Task Conditions

Cited by 4 publications

References 103 publications

Functional correlates of brain aging: beta and gamma components of event-related band responses

Functional correlates of brain aging: beta and gamma components of event-related band responses

EWA-DB, Slovak Database of Speech Affected by Neurodegenerative Diseases

Neurophysiological investigation of auditory intensity dependence in patients with Parkinson’s disease

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