Event-related potentials in a passive and active auditory condition: effects of diazepam and buspirone on slow wave positivity

Unrug, A.; Luijtelaar, E.L.J.M. van; Coles, Michael; Coenen, A.M.L.

doi:10.1016/s0301-0511(96)05237-4

Cited by 17 publications

(9 citation statements)

References 23 publications

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“…This difference in sensitivity may be due to cancellation of base-line¯uctuations, as both the negative and positive peaks would be equally affected by such¯uctuations. The vertex electrode (Cz) was found to be the most sensitive scalp location for the evaluation of the effect of diazepam, which is consistent with literature reports [3,9].…”

Section: Discussionsupporting

confidence: 89%

“…Unrug et al [3] found that the decrease in the P300 potential after a 10 mg oral dose of diazepam was most pronounced at the vertex electrode. The peak of the P300 potential is usually identi®ed as the most positive point in the waveform range between 200 and 400 ms and a change in the latency of this peak may also be useful in evaluating changes in P300 caused by diazepam [8].…”

Section: Introductionmentioning

confidence: 99%

“…The P300 potential has been found to be particularly useful in measuring the intracerebral effects of benzodiazepines [8]. After both neutral and target tones a negative wave appears after 100 ms (N100), but only limited changes appear after benzodiazepine administration [3]. As well as being related to the sedative and cognitive effects of benzodiazepines [8], changes in EEG, particularly the increase in betaactivity, has been found to correlate with anticonvulsant effect [10].…”

Section: Introductionmentioning

confidence: 99%

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Electroencephalographic effects and serum concentrations after intranasal and intravenous administration of diazepam to healthy volunteers

Lindhardt

Gizurarson

Stefánsson

et al. 2001

Brit J Clinical Pharma

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Aims To evaluate the electroencephalographic (EEG) effects, blood concentrations, vehicle irritation and dose‐effect relationships for diazepam administered nasally.Methods The study had a cross‐over design with eight healthy volunteers (one drop out). It consisted of four legs with four different administrations: intranasal (i.n.) placebo, 4 mg diazepam i.n., 7 mg diazepam i.n. and 5 mg intravenous (i.v.) diazepam. Polyethylene glycol 300 (PEG300) was used as a vehicle in the nasal formulations to solubilize a clinically relevant dose of diazepam. Changes in N100, P200 and P300 brain event‐related potentials (ERP) elicited by auditory stimulation and electroencephalographic β‐activity were used to assess effects on neurological activity.Results The mean [95% confidence intervals] differences between before and after drug administration values of P300‐N100 amplitude differences were −0.9 [−6.5, 4.7], −6.4 [−10.1, −2,7], −8.6 [−11.4, −5.8] and −9.6 [−12.1, −7.1] for placebo, 4 mg i.n., 7 mg i.n. and 5 mg i.v. diazepam, respectively, indicating statistically significant drug induced effects. The bioavailabilities of 4 and 7 mg i.n. formulations, were found to be similar, 45% [32, 58] and 42% [22, 62], respectively.Conclusion The present study indicates that it is possible to deliver a clinically effective nasal dose of diazepam for the acute treatment of epilepsy, using PEG300 as a solubilizer.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Electroencephalographic effects and serum concentrations after intranasal and intravenous administration of diazepam to healthy volunteers

Lindhardt

Gizurarson

Stefánsson

et al. 2001

Brit J Clinical Pharma

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show abstract

“…This finding is in accordance with the results in the tension-type headache study 31, which might be because many tension-type headache sufferers also displayed signs of depression 57. On the other hand, we could not completely ruled out the medication effects on our findings, since previous studies have shown the effect of anxiolytics or antidepressants on cognition (e.g., attention, memory or learning) 58,59, behavioral aspects (e.g., executive function or motor reaction) 60, and hemispheric asymmetry 48. However, prior to the study, our patients were all medication-free for at least 72 hours, which helped to remove some effects of the anxiolytics or antidepressants.…”

Section: Discussionsupporting

confidence: 85%

Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression

He¹,

Chai²,

Zhang³

et al. 2010

Int. J. Med. Sci.

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Background and Objectives The line bisection error to the left of the true center has been interpreted as a relative right hemisphere activation, which might relate to the subject's emotional state. Considering that patients with generalized anxiety disorder (GAD) or treatment-resistant depression (TRD) often have negative emotions, we hypothesized that these patients would bisect lines significantly leftward. Methods We tried the line bisection task in the right-handed healthy volunteers (n = 56), GAD (n = 47) and TRD outpatients (n = 52). Subjects also completed the Zuckerman - Kuhlman Personality Questionnaire, the Zuckerman Sensation Seeking Scales, and the Plutchik-van Praag Depression Inventory. Results GAD patients scored highest on the Neuroticism-Anxiety trait, TRD patients scored highest on depression, and both patients scored lower on the Sociability trait. Patients with GAD also bisected lines significantly leftward compared to the healthy subjects. The Frequency of the bisection error was negatively correlated with Disinhibition-Seeking in the healthy subjects, and with Total sensation-seeking and Experience-Seeking in GAD patients, while the Magnitude of the line bisection error was negatively correlated with depression in TRD patients. Conclusions The study suggests a stronger right hemispheric activation, a weaker left activation, or both in the GAD, instead of TRD patients.

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“…EEG was derived from Fz, Cz, Pz, Fp1, Fp2, F3, F4, F7, F8, C3, C4, T7, T8, P3, P4, P7, P8, O1 and O2, according to the 10-20 electrode system (Jasper, 1958). The left mastoid served as reference (Unrug et al, 1997). A ground electrode was placed on the forehead.…”

Section: Eeg Recordingsmentioning

confidence: 99%

Rhythmic context influences the auditory evoked potentials of musicians and nonmusicians

Jongsma¹,

Desain²,

Honing³

2004

Biological Psychology

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Event-related potentials in a passive and active auditory condition: effects of diazepam and buspirone on slow wave positivity

Cited by 17 publications

References 23 publications

Electroencephalographic effects and serum concentrations after intranasal and intravenous administration of diazepam to healthy volunteers

Electroencephalographic effects and serum concentrations after intranasal and intravenous administration of diazepam to healthy volunteers

Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depression

Rhythmic context influences the auditory evoked potentials of musicians and nonmusicians

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