Event-related potential (P300) in epilepsy

Fukai, Mitsuhiro; Motomura, Naoyasu; Kobayashi, S.; Asaba, H; Sakai, Toshiaki

doi:10.1111/j.1600-0404.1990.tb04488.x

Cited by 57 publications

(33 citation statements)

References 14 publications

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“…All the studies involving the auditory processing of epileptic patients were performed using auditory evoked responses. 28,29 The high prevalence of disorders reported in the literature when using the auditory processing paradigm through long latency potentials, in conjunction with our findings, suggests that epileptic patients may have sound processing deficits. Several authors, [31][32][33] in their studies with epileptic children, have reported on the importance of areas such as the hippocampus, thalamus, cortical-thalamic circuit, temporal lobe and auditory association cortex in sound processing.…”

Section: Discussionsupporting

confidence: 70%

Staggered spondaic word test in epileptic patients

et al. 2002

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CONTEXT: Auditory processing during childhood may be altered if there is any predisposing factor during the course of development. Neurological disorders are among the risk factors for auditory processing impairment. From this perspective, epileptic children present such a risk factor and could present auditory processing dysfunction. OBJECTIVE: To evaluate central auditory processing in epileptic patients using the Staggered Spondaic Word Test (SSW) in order to verify whether these patients presented auditory disorders and whether the type of crisis partial or generalized played a role in the occurrence and type of disorder. SETTING: Tertiary care hospital. SAMPLE: Thirty-eight children and adolescents, ranging from 7 to 16 years old, with a diagnosis of epilepsy divided into two groups: 23 patients with partial crisis and 15 patients with generalized crisis. MAIN MEASUREMENTS: Performance in the Staggered Spondaic Word Test versus epileptic crisis type (partial or generalized). RESULTS: The majority of epileptic patients showed central auditory processing disorders. There were no differences in relation to crisis type. Both groups showed similar performance, although the results observed for these patients differ from what is obtained with normal populations. With regard to response bias, there were also no differences in performance between subjects with partial or generalized seizures. All possible disorders were found in both groups, without the prevalence of one specific disorder over the other. CONCLUSIONS: This study revealed a high prevalence of disorders among epileptic patients in relation to processing partially overlapped verbal sounds in a dichotic paradigm.

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Section: Discussionsupporting

confidence: 70%

Staggered spondaic word test in epileptic patients

et al. 2002

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“…The analysis now, however, did not show a significant difference in P3 latencies and amplitudes between patients who did suffer from post-encephalitic epilepsy and those who did not. Other Studies of P3 characteristics in epilepsy describe increased latencies and greater amplitudes in epileptic subjects [22][23][24]. Again, one reason for the lack of statistically significant results is the small number of our study participants.…”

Section: In This Study Auditory Erps In 47 Patients Have Been Analyzcontrasting

confidence: 47%

Cognitive Impairment After Acute Encephalitis: An ERP Study

Hahn¹,

Schildmann²,

Baumeister³

et al. 2012

International Journal of Neuroscience

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Cognitive deficits are often observed during the acute stage of encephalitis. It is presumed, that they persist and influence the long-term outcome, but data are very limited. Forty-seven patients with a definite or highly probable diagnosis of acute encephalitis were identified through retrospective analysis and prospectively followed up 6-84 months after the acute illness. P3 was carried out by oddball auditory paradigm, and P3 latency was measured as a marker of cognitive impairment. Healthy people, who matched the patients in age, were used as controls (n = 39). Statistical group analysis revealed no significant difference of the P3 latency between the patient and the control group. However a subgroup analysis showed significant longer P3 latencies in patients with a more unfavorable functional outcome at the time of follow-up. Patients with Herpes simplex virus (HSV) encephalitis had also more often abnormal P3 values compared to other etiologic subgroups, potentially indicating a higher percentage of patients with unfavorable cognitive outcome in this subgroup.

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“…First, steroid treatment (using adrenocorticotropic hormone and corticotropin-releasing hormone at low dose) did not alter ERP latencies in healthy adult controls 51,52. Second, in other severe epilepsies therapeutic doses of other anticonvulsants did not alter ERP latencies 47,53. We did not identify clear ERP differences in relation to clinical factors such as development before seizure onset, the presence of brain MRI abnormality, EEG background abnormality, and focal epileptiform activity, albeit limited by small sample size.…”

Section: Discussionmentioning

confidence: 98%

Temporal lobe impairment in West syndrome: Event‐related potential evidence

Werner

Fosi

Boyd

et al. 2014

Annals of Neurology

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ObjectiveThis study investigates auditory processing in infants with West syndrome (WS) using event-related potentials (ERPs).MethodsERPs were measured in 25 infants with mainly symptomatic WS (age range = 3–10 months) and 26 healthy term infants (age range = 3–9 months) using an auditory novelty oddball paradigm. The ERP recordings were made during wakefulness and repeated in stage II sleep.ResultsThe obligatory components (P150, N250, P350) and novelty response components (P300, Nc) were recordable during both sleep and wakefulness in patients and controls. All ERP latencies decreased with age in controls but not in the WS group (age × group interaction, F = 22.3, p < 0.0001). These ERP latency alterations were not affected by pharmacological treatment for WS.InterpretationThis study demonstrated a persistently altered ERP signature in patients with a recent history of infantile spasms. The prolongation of auditory obligatory and novelty ERPs in WS patients indicates a severe failure of temporal lobe maturation during infancy. It remains to be investigated whether this predicts long-term cognitive impairments characteristic for this epileptic encephalopathy.

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Event-related potential (P300) in epilepsy

Cited by 57 publications

References 14 publications

Staggered spondaic word test in epileptic patients

Staggered spondaic word test in epileptic patients

Cognitive Impairment After Acute Encephalitis: An ERP Study

Temporal lobe impairment in West syndrome: Event‐related potential evidence

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