Temporal lobe impairment in <scp>W</scp>est syndrome: Event‐related potential evidence

Werner, Klaus; Fosi, Tangunu; Boyd, Stewart; Baldeweg, Torsten; Scott, Rod C.; Neville, Brian

doi:10.1002/ana.24297

Cited by 9 publications

(6 citation statements)

References 57 publications

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“…This result indicates that local neuronal activities of these regions are interrupted in IS patients. A recent study with event-related potentials design indicate that there might be a failure of temporal lobe maturation during infancy in IS patients ( 37 ). Another study in IS patients also showed that the white matter development in temporal lobe is impaired through tract-based statistics analysis ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms

Wang

Wang³

et al. 2017

Front. Neurol.

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Infantile spasms (IS) syndrome is an age-dependent epileptic encephalopathy, which occurs in children characterized by spasms, impaired consciousness, and hypsarrhythmia. Abnormalities in default mode network (DMN) might contribute to the loss of consciousness during seizures and cognitive deficits in children with IS. The purpose of the present study was to investigate the changes in DMN with functional connectivity (FC) and amplitude of low-frequency fluctuation (ALFF), the two methods to discover the potential neuronal underpinnings of IS. The consistency of the two calculate methods of DMN abnormalities in IS patients was also our main focus. To avoid the disturbance of interictal epileptic discharge, our testing was performed within the interictal durations without epileptic discharges. Resting-state fMRI data were collected from 13 patients with IS and 35 sex- and age-matched healthy controls. FC analysis with seed in posterior cingulate cortex (PCC) was used to compare the differences between two groups. We chose PCC as the seed region because PCC is the only node in the DMN that directly interacts with virtually all other nodes according to previous studies. Furthermore, the ALFF values within the DMN were also calculated and compared between the two groups. The FC results showed that IS patients exhibited markedly reduced connectivity between posterior seed region and other areas within DMN. In addition, part of the brain areas within the DMN showing significant difference of FC had significantly lower ALFF signal in the patient group than that in the healthy controls. The observed disruption in DMN through the two methods showed that the coherence of brain signal fluctuation in DMN during rest was broken in IS children. Neuronal functional impairment or altered integration in DMN would be one neuroimaging characteristic, which might help us to understand the underlying neural mechanism of IS. Further studies are needed to determine whether the disturbed FC and ALFF observed in the DMN are related to cognitive performance in IS patients.

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Section: Discussionmentioning

confidence: 99%

Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms

Wang

Wang³

et al. 2017

Front. Neurol.

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“…The acoustic stimuli and ERP measurements have been described . Prior to data processing, the data were re‐referenced offline to linked mastoid electrodes (M1/M2).…”

Section: Methodsmentioning

confidence: 99%

Auditory processing following infantile spasms: An event‐related potential study

Fosi

Werner²,

Boyd

et al. 2017

Epilepsia

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“…As reported elsewhere, CAEP has been found to be sensitive in identifying hearing loss and disorders affecting the central auditory pathway including tumors, multiple sclerosis, and brain injury [5][6][7]. Abnormal CAEP waveforms have also been reported in children with syndromic features, attention deficit hyperactivity disorder, autism, learning disabilities, auditory processing disorder, auditory neuropathy, and epilepsy [8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 66%

Effects of Age and Type of Stimulus on the Cortical Auditory Evoked Potential in Healthy Malaysian Children

et al. 2020

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Background and Objectives: The cortical auditory evoked potential (CAEP) is a useful objective test for diagnosing hearing loss and auditory disorders. Prior to its clinical applications in the pediatric population, the possible influences of fundamental variables on the CAEP should be studied. The aim of the present study was to determine the effects of age and type of stimulus on the CAEP waveforms. Subjects and Methods: Thirty-five healthy Malaysian children aged 4 to 12 years participated in this repeated-measures study. The CAEP waveforms were recorded from each child using a 1 kHz tone burst and the speech syllable /ba/. Latencies and amplitudes of P1, N1, and P2 peaks were analyzed accordingly. Results: Significant negative correlations were found between age and speech-evoked CAEP latency for each peak (p< 0.05). However, no significant correlations were found between age and tone-evoked CAEP amplitudes and latencies (p>0.05). The speech syllable /ba/ produced a higher mean P1 amplitude than the 1 kHz tone burst (p=0.001). Conclusions: The CAEP latencies recorded with the speech syllable became shorter with age. While both tone-burst and speech stimuli were appropriate for recording the CAEP, significantly bigger amplitudes were found in speech-evoked CAEP. The preliminary normative CAEP data provided in the present study may be beneficial for clinical and research applications in Malaysian children.

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Temporal lobe impairment in West syndrome: Event‐related potential evidence

Cited by 9 publications

References 57 publications

Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms

Altered Default Mode Network on Resting-State fMRI in Children with Infantile Spasms

Auditory processing following infantile spasms: An event‐related potential study

Effects of Age and Type of Stimulus on the Cortical Auditory Evoked Potential in Healthy Malaysian Children

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