Event-Related Oscillations in Offspring of Alcoholics: Neurocognitive Disinhibition as a Risk for Alcoholism

Kamarajan, Chella; Porjesz, Bernice; Jones, Kevin; Chorlian, David B.; Padmanabhapillai, Ajayan; Rangaswamy, Madhavi; Stimus, Arthur T.; Begleiter, Henri

doi:10.1016/j.biopsych.2005.08.017

Cited by 108 publications

(137 citation statements)

References 108 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…The delta band differences reported in alcoholics (Kamarajan et al, 2004, Jones et al, in preparation) and offspring of alcoholics (Kamarajan et al, 2006) and in the present study closely corresponds to P300 differences reported in alcoholics and high risk subjects . It has been suggested that delta activity is generated by cortico-cortical interactions with some subcortical contributions.…”

Section: Event-related Delta Band Changessupporting

confidence: 90%

“…Evoked theta power was not significantly different between the two groups, although few electrode locations in central and parietal regions showed weakly significant differences. Kamarajan et al (2006)in a study of oscillations in adult high risk offspring in a Go-Nogo P3 paradigm, also report a strongly reduced theta band power only in the parietal regions for the Go condition. The responses to the Go condition in this task closely resemble the oddball target condition, although the stimuli used in the task are different.…”

Section: Event-related Theta Band Changesmentioning

confidence: 88%

“…The responses to the Go condition (that closely resembles the oddball target condition) had reduced delta band power in the parietal occipital and frontal regions. In a follow-up study on adult high risk offspring, the same authors report a strongly reduced delta band power in the parietal regions only for the Go condition (Kamarajan et al, 2006).…”

Section: Event-related Delta Band Changesmentioning

confidence: 90%

See 2 more Smart Citations

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

Self Cite

117

136

View full text Add to dashboard Cite

Background-Visual P300 is consistently lower in alcohol dependent individuals, their offspring and subjects at risk. Delta and theta event related oscillations (ERO) are the major contributors to the P300 signal. The total and evoked power in delta and theta bands in the 300 to 700 millisecond post-stimulus window (corresponding to the zone of P3 maxima) was compared between adolescent offspring of alcoholics (high-risk) and age-matched normal controls (low-risk), to assess the utility of the risk markers.Methods-EEG was recorded during the performance of visual oddball task. The S-Transform algorithm decomposed the EEG signals into different frequency bands and the group differences in total and evoked power in the oscillatory responses during the P300 time window (300 to 700 ms) were analyzed using a multivariate design. Similar analysis was performed on P300 peak amplitudes for the target.Results-The high-risk group showed significantly lower parietal post-stimulus evoked and total power in the delta band for targets. A decrease in total power was seen centrally and parietally in theta band. The P300 peak amplitude in the parietal electrodes was also significantly lower in the high-risk group.Conclusions-The decreased total theta power and total and evoked delta power for visual targets in high risk individuals may serve as an endophenotypic marker in the development of alcoholism and other disinhibitory disorders. The differences seen between the offspring of alcoholics and controls may have a cholinergic basis. The ERO measures appear to be more robust than the P300 amplitude in differentiating the groups.

show abstract

Section: Event-related Delta Band Changessupporting

confidence: 90%

Section: Event-related Theta Band Changesmentioning

confidence: 88%

Section: Event-related Delta Band Changesmentioning

confidence: 90%

See 1 more Smart Citation

Delta and theta oscillations as risk markers in adolescent offspring of alcoholics

Rangaswamy

Jones

Porjesz

et al. 2007

International Journal of Psychophysiology

Self Cite

117

136

View full text Add to dashboard Cite

show abstract

“…It is also supported by abnormalities in brain electrophysiology (e.g. Kamarajan et al 2006) and brain metabolism (e.g. Scheinsburg et al 2004) during the performance of response inhibition tasks.…”

Section: Introductionmentioning

confidence: 99%

Alcohol cues increase cognitive impulsivity in individuals with alcoholism

et al. 2007

View full text Add to dashboard Cite

Background Individuals with alcoholism are characterized by both attentional bias for alcohol cues and prepotent response inhibition deficit. We tested the hypothesis that alcoholics exhibit greater cognitive disinhibition when the response to be suppressed is associated with alcohol-related information. Methods Forty recently detoxified individuals with alcoholism were compared with 40 healthy non-substance abusers on the "Alcohol-Shifting Task", a variant of the go/no-go paradigm requiring a motor response to targets and no response to distracters. The aim was to test the ability of alcoholics to discriminate between alcohol-related and neutral words. Sometimes, the alcohol-related words were the targets for the "go" response, with neutral words as distracters, sometimes the reverse. Several shifts in target type occurred during the task. Results Alcoholics made significantly more commission errors (i.e., press a key when a distracter displayed) and more omission errors (i.e., not press a key when a target displayed) than controls. Moreover, the number of commission errors was greater in alcoholics when alcoholrelated stimuli had to be detected. Conclusions These results demonstrate that alcoholics exhibit a basic prepotent response inhibition deficit, which is enhanced when the response to be suppressed is related to alcohol. We discuss clinical and theoretical implications of these findings.

show abstract

“…Disinhibition, i.e., the impaired ability to inhibit a potentially inappropriate response, is a common feature of substance misuse (Chen et al 2007; Kamarajan et al 2006;Kirisci et al 2006;Verdejo-Garcia et al 2006). Neuroimaging studies have reported both prefrontal and posterior parietal cortical involvement during inhibitory processing in healthy volunteers (Liu et al 2004), which may be overactive in populations with impulse control problems (Schulz et al 2004).…”

Section: Introductionmentioning

confidence: 99%