Event-related fMRI responses in the human frontal eye fields in a randomized pro- and antisaccade task

Cornelissen, Frans W.; Kimmig, H.; Schira, Mark M.; Rutschmann, Roland M.; Maguire, R. Paul; Broerse, A.; Boer, Johan A. den; Greenlee, Mark W.

doi:10.1007/s00221-002-1136-3

Cited by 69 publications

(31 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is possible that there were differences between the extent of eye movements during the object directed and non-object directed conditions, which would result in activity in posterior and frontal eye fields. However are coordinates do not overlap with those reported by studies investigating eye movements [51], [52]. Therefore we do not believe that differences in eye movements can explain these results.…”

Section: Discussioncontrasting

confidence: 50%

Dissociating Object Directed and Non-Object Directed Action in the Human Mirror System; Implications for Theories of Motor Simulation

2012

View full text Add to dashboard Cite

Mirror neurons are single cells found in macaque premotor and parietal cortices that are active during action execution and observation. In non-human primates, mirror neurons have only been found in relation to object-directed movements or communicative gestures, as non-object directed actions of the upper limb are not well characterized in non-human primates. Mirror neurons provide important evidence for motor simulation theories of cognition, sometimes referred to as the direct matching hypothesis, which propose that observed actions are mapped onto associated motor schemata in a direct and automatic manner. This study, for the first time, directly compares mirror responses, defined as the overlap between action execution and observation, during object directed and meaningless non-object directed actions. We present functional MRI data that demonstrate a clear dissociation between object directed and non-object directed actions within the human mirror system. A premotor and parietal network was preferentially active during object directed actions, whether observed or executed. Moreover, we report spatially correlated activity across multiple voxels for observation and execution of an object directed action. In contrast to predictions made by motor simulation theory, no similar activity was observed for non-object directed actions. These data demonstrate that object directed and meaningless non-object directed actions are subserved by different neuronal networks and that the human mirror response is significantly greater for object directed actions. These data have important implications for understanding the human mirror system and for simulation theories of motor cognition. Subsequent theories of motor simulation must account for these differences, possibly by acknowledging the role of experience in modulating the mirror response.

show abstract

Section: Discussioncontrasting

confidence: 50%

Dissociating Object Directed and Non-Object Directed Action in the Human Mirror System; Implications for Theories of Motor Simulation

2012

View full text Add to dashboard Cite

show abstract

“…FEF and SEF correspond to anatomic areas, the intersection between precentral sulcus and superior frontal sulcus (FEF), and the medial surface of the superior frontal gyrus (SEF), respectively. Note that to be consistent with previous saccade neuroimaging literature, we have provided functional rather than anatomic names for these structures, based on previously published coordinates (Luna et al, 1998; Cornelissen et al, 2002; Connolly et al, 2007). …”

Section: Resultsmentioning

confidence: 90%

Cortical Activation during Landmark-Centered vs. Gaze-Centered Memory of Saccade Targets in the Human: An FMRI Study

Chen

Crawford

2017

Front. Syst. Neurosci.

View full text Add to dashboard Cite

A remembered saccade target could be encoded in egocentric coordinates such as gaze-centered, or relative to some external allocentric landmark that is independent of the target or gaze (landmark-centered). In comparison to egocentric mechanisms, very little is known about such a landmark-centered representation. Here, we used an event-related fMRI design to identify brain areas supporting these two types of spatial coding (i.e., landmark-centered vs. gaze-centered) for target memory during the Delay phase where only target location, not saccade direction, was specified. The paradigm included three tasks with identical display of visual stimuli but different auditory instructions: Landmark Saccade (remember target location relative to a visual landmark, independent of gaze), Control Saccade (remember original target location relative to gaze fixation, independent of the landmark), and a non-spatial control, Color Report (report target color). During the Delay phase, the Control and Landmark Saccade tasks activated overlapping areas in posterior parietal cortex (PPC) and frontal cortex as compared to the color control, but with higher activation in PPC for target coding in the Control Saccade task and higher activation in temporal and occipital cortex for target coding in Landmark Saccade task. Gaze-centered directional selectivity was observed in superior occipital gyrus and inferior occipital gyrus, whereas landmark-centered directional selectivity was observed in precuneus and midposterior intraparietal sulcus. During the Response phase after saccade direction was specified, the parietofrontal network in the left hemisphere showed higher activation for rightward than leftward saccades. Our results suggest that cortical activation for coding saccade target direction relative to a visual landmark differs from gaze-centered directional selectivity for target memory, from the mechanisms for other types of allocentric tasks, and from the directionally selective mechanisms for saccade planning and execution.

show abstract

“…Some studies used event-related fMRI in order to do mixed-choice trial presentations and to link the brain areas to specific components for these eye movements (Cornelissen et al, 2002; Curtis and D'Esposito, 2003, 2006; Desouza et al, 2003; Ford et al, 2005; Brown et al, 2007; Dyckman et al, 2007; Ettinger et al, 2008). It is possible with event-related fMRI to use a design in which prosaccade and antisaccade trials are randomly intermixed (mixed-choice trials design).…”

Section: Introductionmentioning

confidence: 99%

Cortical sources of ERP in prosaccade and antisaccade eye movements using realistic source models

Richards¹

2013

Front. Syst. Neurosci.

View full text Add to dashboard Cite

The cortical sources of event-related-potentials (ERP) using realistic source models were examined in a prosaccade and antisaccade procedure. College-age participants were presented with a preparatory interval and a target that indicated the direction of the eye movement that was to be made. In some blocks a cue was given in the peripheral location where the target was to be presented and in other blocks no cue was given. In Experiment 1 the prosaccade and antisaccade trials were presented randomly within a block; in Experiment 2 procedures were compared in which either prosaccade and antisaccade trials were mixed in the same block, or trials were presented in separate blocks with only one type of eye movement. There was a central negative slow wave occurring prior to the target, a slow positive wave over the parietal scalp prior to the saccade, and a parietal spike potential immediately prior to saccade onset. Cortical source analysis of these ERP components showed a common set of sources in the ventral anterior cingulate and orbital frontal gyrus for the presaccadic positive slow wave and the spike potential. In Experiment 2 the same cued- and non-cued blocks were used, but prosaccade and antisaccade trials were presented in separate blocks. This resulted in a smaller difference in reaction time between prosaccade and antisaccade trials. Unlike the first experiment, the central negative slow wave was larger on antisaccade than on prosaccade trials, and this effect on the ERP component had its cortical source primarily in the parietal and mid-central cortical areas contralateral to the direction of the eye movement. These results suggest that blocked prosaccade and antisaccade trials results in preparatory or set effects that decreases reaction time, eliminates some cueing effects, and is based on contralateral parietal-central brain areas.

show abstract

Event-related fMRI responses in the human frontal eye fields in a randomized pro- and antisaccade task

Cited by 69 publications

References 20 publications

Dissociating Object Directed and Non-Object Directed Action in the Human Mirror System; Implications for Theories of Motor Simulation

Dissociating Object Directed and Non-Object Directed Action in the Human Mirror System; Implications for Theories of Motor Simulation

Cortical Activation during Landmark-Centered vs. Gaze-Centered Memory of Saccade Targets in the Human: An FMRI Study

Cortical sources of ERP in prosaccade and antisaccade eye movements using realistic source models

Contact Info

Product

Resources

About