Event-related evoked potential versus clinical tests in assessment of subclinical cognitive impairment in chronic hepatitis C virus

Fathelbab, Hanaa Khalaf; Ahmed, Elham; Mansour, Dina F.; Soliman, Wail Talaat

doi:10.1186/s41983-018-0034-y

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…The International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) still preserved some role for the P300 in the research setting (Guerit et al 2009). Most recently, the P300 validity has been strongly revived by Fath-Elbab et al (2018), since this index could disclose "minimal and subclinical impairment of cognitive function at early stages of chronic hepatitis with accuracy". Having controlled for confounding factors such age and alcohol consumption (Duncan et al 2009), we thus value the P300 latency lengthening in HCVs as an objective counterpart of the subtle cognitive changes observed.…”

Section: Discussionmentioning

confidence: 99%

“…Though not formally indicated for clinical use (Amodio and Montagnese 2015), it may "provide an insight into the cognitive processes in research settings" (Guerit et al 2009). Recently, its usefulness was strongly revived (Fath-Elbab et al 2018). Therefore, we hypothesized that P300 would be quite appropriate an instrumental measure, to strengthen the neuropsychological findings expected before and after the DAA treatment.…”

Section: Introductionmentioning

confidence: 99%

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Direct antivirals and cognitive impairment in hepatitis C: a clinical-neurophysiologic study

et al. 2020

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Cognition was assessed in hepatitis C virus (HCV) patients, who did not meet the criteria for a minimal hepatic encephalopathy. Their liver function was compensated. We then disentangled potential cognitive changes associated with a sustained virologic response at 12 weeks (SVR-12), following treatment with direct antiviral agents (DAAs). We studied 23 selected HCV patients with a battery of standard neuropsychological tests, and with recordings of the P300 wave, a cerebral potential of “cognitive” significance. There was a baseline evaluation (T0) and a second one 6 months later (T1). We had 2 control groups of comparable age and sex, i.e., 15 patients suffering from non-alcoholic fatty liver disease (NAFLD) and 15 healthy subjects. At T0, we detected a significant (p < 0.05) cognitive impairment in the HCV group, which involved episodic and working memory, attention, visuospatial and verbal abilities, executive functions, and logic reasoning. The P300 latency was significantly (p < 0.05) delayed in the group. At T1, we observed some significant (p < 0.05) HCV recovery in given test domains, e.g., memory, executive functions, and reasoning. Accordingly, the P300 latency shortened significantly (p < 0.05). HCV patients exhibited subtle cognitive defects, somehow independent of their liver condition, possibly linked to direct or indirect brain involvement by the virus. These defects partly recovered following the SVR-12, as achieved through DAAs. The P300 wave was a valid neurophysiologic counterpart of these changes. DAAs can have a role in the early preservation of cognition in HCVs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Direct antivirals and cognitive impairment in hepatitis C: a clinical-neurophysiologic study

et al. 2020

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Evaluation of Event-Related Potentials in Somatic Diseases – Systematic Review

Popiołek,

Niznikiewicz,

Borkowska

et al. 2024

Appl Psychophysiol Biofeedback

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Cognitive screening in HTLV-1–infected people using a self-perceived memory score and auditory P300

et al. 2022

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Background: The HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is the most common neurological manifestation associated with Human T-cell Lymphotropic Virus type-1 (HTLV-1) infection. Although cognitive impairment has been highlighted in the spectrum of HTLV-1 neurological manifestations, it may go unnoticed in those who do not spontaneously report it. We aimed at evaluating the applicability of a self-perceived memory score (SMS) and the cognitive event-related potential (P300) for the early detection of cognitive impairment in HTLV-1-infected people.Methods: The SMS was measured by a 0-10 visual analog scale combined with a sad-happy faces rating scale. The higher the number, the better was the SMS. The P300 was obtained through an oddball paradigm with a mental counting task. The participants were 15(21,4%) individuals with HAM/TSP, 20(28,6%) HTLV-1-asymptomatic carriers, and 35(50%) seronegative controls.Results: SMS (p<0.001) and P300 latency (p<0.001) got progressively worse from asymptomatic to HAM/TSP. A SMS <7.2 points and a P300 latency >369.0 milliseconds were considered as altered result and indicated cognitive impairment. The HAM/TSP group showed the highest prevalence of altered P300 (80%) and SMS (87%). Interestingly, the asymptomatic group also presented signi cant higher prevalence of altered SMS (60%) and P300 (35%) when compared to controls (<10%). The frequency of cognitive impairment was 16 times higher in the asymptomatic group and 69 times higher in the HAM/TSP group when compared to controls. Conclusion:The use of SMS in the medical consultation was a useful and easy-to-apply method to screen HTLV-1 infected subjects for everyday memory complaints. BackgroundThe rst descriptions of the neurological disease associated with HTLV-1 infections were based on the motor function assessed by mobility and strength disability [1, 2]. The HTLV-1 associated myelopathy / tropical spastic paraparesis (HAM/TSP) is a chronic, slow-progressing neurological in ammatory disease that affects approximately 4% of the infected individuals [3, 4]. However, the prevalence of neurological disorders that do not meet the criteria for de nite HAM/TSP, such as urinary disorders, sexual dysfunction and skin lesions, can occur in around 30% of those individuals classi ed as HTLV-1-asymptomatic carriers [4][5][6]. In fact, non-medullary symptoms have been neglected in the HTLV-1 infection [7].Recent evidences have showed that HTLV-1 is related to a complex of neurological manifestations that are not limited to the clinical spectrum of HAM/TSP, affecting all the segments of the central nervous system to a greater or lesser extent [3,[8][9][10][11][12][13][14][15][16][17][18]. In this context, cognitive impairment has been reported as one of the manifestations of the HTLV-1 infection [11,13,[19][20][21][22][23][24]. On the other hand, HAM/TSP remains as the most important neurological disease associated with 26]. Therefore, cognitive impairment can be underdiagnosed and may go unnoticed in those indivi...

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Event-related evoked potential versus clinical tests in assessment of subclinical cognitive impairment in chronic hepatitis C virus

Cited by 4 publications

References 33 publications

Direct antivirals and cognitive impairment in hepatitis C: a clinical-neurophysiologic study

Direct antivirals and cognitive impairment in hepatitis C: a clinical-neurophysiologic study

Evaluation of Event-Related Potentials in Somatic Diseases – Systematic Review

Cognitive screening in HTLV-1–infected people using a self-perceived memory score and auditory P300

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