Evening Chronotype Is Associated With Metabolic Disorders and Body Composition in Middle-Aged Adults

Yu, Ji Hee; Yun, Chang Ho; Ahn, Jae‐Jun; Suh, Sooyeon; Cho, Hyun Joo; Lee, Seung Ku; Yoo, Hye Jin; Seo, Ji A; Kim, Sin Gon; Choi, Kyung Mook; Baik, Sei Hyun; Choi, Dong Seop; Shin, Chol; Kim, Nan Hee

doi:10.1210/jc.2014-3754

Cited by 283 publications

(238 citation statements)

References 46 publications

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“…As sleep–wake timing and diurnal preference have been associated with individual differences in sleep quality,49 metabolism,50 and mental health,51 we also assessed this aspect of sleep. PC1 component explained 34% of the variation across all studied measures within this domain (see Table 4).…”

Section: Resultsmentioning

confidence: 99%

Sleep deficits but no metabolic deficits in premanifest Huntington's disease

Lázár

Panin

Goodman

et al. 2015

Annals of Neurology

104

107

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ObjectiveHuntington disease (HD) is a fatal autosomal dominant, neurodegenerative condition characterized by progressively worsening motor and nonmotor problems including cognitive and neuropsychiatric disturbances, along with sleep abnormalities and weight loss. However, it is not known whether sleep disturbances and metabolic abnormalities underlying the weight loss are present at a premanifest stage.MethodsWe performed a comprehensive sleep and metabolic study in 38 premanifest gene carrier individuals and 36 age‐ and sex‐matched controls. The study consisted of 2 weeks of actigraphy at home, 2 nights of polysomnography and multiple sleep latency tests in the laboratory, and body composition assessment using dual energy x‐ray absorptiometry scanning with energy expenditure measured over 10 days at home by doubly labeled water and for 36 hours in the laboratory by indirect calorimetry along with detailed cognitive and clinical assessments. We performed a principal component analyses across all measures within each studied domain.ResultsCompared to controls, premanifest gene carriers had more disrupted sleep, which was best characterized by a fragmented sleep profile. These abnormalities, as well as a theta power (4–7Hz) decrease in rapid eye movement sleep, were associated with disease burden score. Objectively measured sleep problems coincided with the development of cognitive, affective, and subtle motor deficits and were not associated with any metabolic alterations.InterpretationThe results show that among the earliest abnormalities in premanifest HD is sleep disturbances. This raises questions as to where the pathology in HD begins and also whether it could drive some of the early features and even possibly the pathology. Ann Neurol 2015;78:630–648

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Section: Resultsmentioning

confidence: 99%

Sleep deficits but no metabolic deficits in premanifest Huntington's disease

Lázár

Panin

Goodman

et al. 2015

Annals of Neurology

104

107

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“…The shiftworkers in the UK Biobank were more likely to report an evening preference, which may be important as this phenotype is associated with susceptibility to metabolic disease including increased BMI, [33][34][35] metabolic syndrome, [33] type 2 diabetes and hypertension, [35] as well as all-cause mortality, [36] and might contribute to the increased prevalence of metabolic disease in shiftworkers.…”

Section: Discussionmentioning

confidence: 99%

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

et al. 2017

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“…2,3 A direct relationship between circadian rhythm disruption and skeletal muscle disease has not been identified in humans. However, several basic studies of different mouse models of clock gene deficiency have found that molecular clock disruption affects skeletal muscle physiology.…”

Section: Resultsmentioning

confidence: 99%

“…However, Yu et al recently found that the prevalence of diabetes, metabolic syndrome, and sarcopenia is 8.2%, 7.4%, and 6.7% higher, respectively, in individuals classified as having an evening, rather than a morning, chronotype among middle-aged Korean population, although the average age was lower in individuals with an evening, rather than a morning, chronotype. 2 Although submit your manuscript | www.dovepress.com…”

Section: Introductionmentioning

confidence: 99%

The skeletal muscle circadian clock: current insights

Nakao¹,

Nikawa²,

Oishi³

2017

CPT

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Skeletal muscle functions in locomotion, postural support, and energy metabolism. The loss of skeletal muscle mass and function leads to diseases such as sarcopenia and metabolic disorders. Inactivity (lack of exercise) and an imbalanced diet (increased fat or decreased protein intake) are thought to be involved in the prevalence of such pathologies. On the other hand, recent epidemiological studies of humans have suggested that circadian disruption caused by shift work, jet lag, and sleep disorders is associated with obesity and metabolic syndrome. Experimental studies of mice deficient in clock genes have also identified skeletal muscle defects, suggesting a molecular link between circadian clock machinery and skeletal muscle physiology. Furthermore, accumulating evidence about chronotherapy, including chronopharmacology, chrononutrition, and chronoexercise, has indicated that timing is important to optimize medical intervention for various diseases. The present review addresses current understanding of the functional roles of the molecular clock with respect to skeletal muscle and the potential of chronotherapy for diseases associated with skeletal muscle.

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Evening Chronotype Is Associated With Metabolic Disorders and Body Composition in Middle-Aged Adults

Abstract: At the population level, evening chronotype was independently associated with diabetes, metabolic syndrome, and sarcopenia. These results support the importance of circadian rhythms in metabolic regulation.

Cited by 283 publications

References 46 publications

Sleep deficits but no metabolic deficits in premanifest Huntington's disease

Sleep deficits but no metabolic deficits in premanifest Huntington's disease

Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank

The skeletal muscle circadian clock: current insights

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