evelopment and Validation of Few UV Spectrophotometric Methods for the determination of Valganciclovir in Bulk and Pharmaceutical Dosage Form

Mondal, Sambhu Charan; Reddy, Goluguri Sunil; Mondal, Prasenjit; Prathyusha, V.; Nair, Aishwarya P; Rahaman, Syed Tazib

doi:10.5530/phm.2018.2.12

Cited by 14 publications

(8 citation statements)

References 5 publications

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“…The simplest way to run various analyses is using the principle of UV-spectroscopy. A blank solution for the diluent was maintained 19 . From 200 to 400 nm, samples were recorded.…”

Section: Methods a (Zero Order Spectrophotometric Method)mentioning

confidence: 99%

A Stability Indicating Method was Developed and Validation for the Estimation of Carbamazepine in Bulk and Tablet Dosage form by UV-Spectroscopic Techniques

Ghosh

Mondal

Chakraborty

et al. 2023

J. Drug Delivery Ther.

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Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy. It is well known that contemporary pharmaceutical analysis establishes robust, sensitive, economic, stability-indicating analytical procedures. The current study aimed to develop and assess UV-spectrophotometric (zero order, first order, second order, area under the curve) methods for estimating carbamazepine in its pharmaceutical dosage form. Method A is a simple zero-order spectrophotometric method for determining carbamazepine at 285 nm, and the correlation coefficient in the linearity study was found to be 0.9976, LOD, and LOQ are 0.45 and 1.48 µg/ml. Method B is a first-order spectrophotometric method for determining carbamazepine at 269 nm, and the correlation coefficient in the linearity study was found to be 0.9944, LOD, and LOQ are 0.29 and 0.96 µg/ml. Method C is a second-order spectrophotometric method for determining carbamazepine at 254 nm, and the correlation coefficient in the linearity study was found to be 1.00, LOD, and LOQ are 0.62 and 2.04 µg/ml. Method D is an area under the curve spectrophotometric method for determining carbamazepine at 266 to 300 nm, and the correlation coefficient in the linearity study was found to be 0.9975, LOD, and LOQ are 0.14 and 0.46 µg/ml. All developed methods demonstrated good repeatability and recovery with %RSD < 2. Studies on stress degradation show that oxidation and acid degradation mostly impact carbamazepine solutions. Keywords: Carbamazepine, UV-spectrophotometric, Tegrital, Degradation study.

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“…The simplest way to run various analyses is using the principle of UV-spectroscopy. A blank solution for the diluent was maintained 19 . From 200 to 400 nm, samples were recorded.…”

Section: Methods a (Zero Order Spectrophotometric Method)mentioning

confidence: 99%

A Stability Indicating Method was Developed and Validation for the Estimation of Carbamazepine in Bulk and Tablet Dosage form by UV-Spectroscopic Techniques

Ghosh

Mondal

Chakraborty

et al. 2023

J. Drug Delivery Ther.

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show abstract

“…Using the UV-spectroscopy concept is the simplest technique to conduct numerous investigations. A blank solution for the diluent was maintained [20]. From 200 to 400 nm, samples were recorded.…”

Section: Methods a (Zero Order Spectrophotometric Method)mentioning

confidence: 99%

A Promising Analytical Method has been Crafted, Validated, and Quantified for Estimating Theophylline Utilizing UV Spectroscopic and RP-HPLC Techniques in Conjunction with Stress Degradation Studies to Pinpoint Deterioration

Madhavi

Mondal

Chakraborty

et al. 2023

J. Pharm. Res. Int.

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Introduction: The current study aimed to develop and assess UV-spectrophotometric (zero order, first order, second order, area under the curve) and RP-HPLC methods for estimating theophylline in its pharmaceutical dosage form. Methods: A less toxic solvent composition of acetonitrile and 0.1% orthophosphoric acid (25:75 v/v) is used as a mobile phase and diluent for developing both UV-spectroscopic and RP-HPLC techniques. Shimadzu Prominence LC-20A Modular HPLC system with a C18 column (250 × 4.6 mm; 5 µm) was used to develop the RP-HPLC method. Results: Method A is a zero-order spectrophotometric method for determining theophylline at 271 nm, and the correlation coefficient in the linearity study was found to be 0.9958, LOD, and LOQ are 0.52 and 1.71 µg/mL. Method B is a first-order spectrophotometric method for determining theophylline at 258 nm, and the correlation coefficient in the linearity study was found to be 0.9983, LOD, and LOQ are 0.46 and 1.51 µg/mL. Method C is a second-order spectrophotometric method for determining theophylline at 218 nm, and the correlation coefficient in the linearity study was found to be 0.9941, LOD, and LOQ are 0.38 and 1.25 µg/mL. Method D is an area under the curve spectrophotometric method for determining theophylline at 260 to 282 nm, and the correlation coefficient in the linearity study was found to be 0.9978, LOD, and LOQ are 0.57 and 1.88 µg/mL. Method E is the RP-HPLC method for the determination of theophylline at the retention time of 2.814 min, and the correlation coefficient in the linearity study was found to be 0.9923, LOD, and LOQ are 0.78 and 2.57 µg/mL. Studies on stress degradation show that oxidation and acid degradation mostly impact theophylline solutions. Conclusion: Theophylline can be determined using the proposed approach, which is convenient, precise, affordable, and reproducible.

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“…Literature survey reveals analytical methods reported for estimation of Famciclovir in API, pharmaceutical dosage form and biological fluid includes spectrophotometry [1][2][3][4] and RP-HPLC [5][6][7]. The HPLC and LC-MS analytical techniques are quite expensive and not easily available in every lab.…”

Section: Acknowledgmentsmentioning

confidence: 99%

UV spectrophotometric method for estimation of famciclovir in pharmaceutical formulation

Afreen¹,

Sy²,

T³

2021

GSC Biol. and Pharm. Sci.

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A simple, rapid, sensitive and accurate UV-spectrophotometric method has been developed for the estimation of Famciclovir in pharmaceutical formulation. The method was developed by using 0.1 N HCl as a solvent and absorbance was measured at 312 nm. The drug exhibited the linearity in the concentration range of 2-12 μg/ml with a correlation coefficient of 0.9978. The % recovery of the drug was found to be 98.62 % - 100.5 %. The method was validated as per ICH guidelines. The proposed method is economical and sensitive for the estimation of Famciclovir in bulk and tablet dosage form.

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evelopment and Validation of Few UV Spectrophotometric Methods for the determination of Valganciclovir in Bulk and Pharmaceutical Dosage Form

Cited by 14 publications

References 5 publications

A Stability Indicating Method was Developed and Validation for the Estimation of Carbamazepine in Bulk and Tablet Dosage form by UV-Spectroscopic Techniques

A Stability Indicating Method was Developed and Validation for the Estimation of Carbamazepine in Bulk and Tablet Dosage form by UV-Spectroscopic Techniques

A Promising Analytical Method has been Crafted, Validated, and Quantified for Estimating Theophylline Utilizing UV Spectroscopic and RP-HPLC Techniques in Conjunction with Stress Degradation Studies to Pinpoint Deterioration

UV spectrophotometric method for estimation of famciclovir in pharmaceutical formulation

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