Evanescent wave sensing: new features for detection in small volumes

Pandraud, G.; Koster, T.M.; Chen, Gui; Dijkstra, M.; Berg, Albert van den; Lambeck, Paul

doi:10.1016/s0924-4247(00)00367-8

Cited by 61 publications

(43 citation statements)

References 13 publications

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“…This is substantiated by previously reported atomic force microscopy analysis showing that the surface roughness of PECVD SiO 2 films can be about one order of magnitude larger than that of thermally grown SiO 2 . 26 Thus, for such poor-quality oxide, selective deposition in the contact windows can only be achieved if the Al/a-Si layer stack can be patterned with very little overlap of the contact window.…”

Section: Influence Of the Dielectric Surface Propertiesmentioning

confidence: 99%

On the Mechanisms Governing Aluminum-Mediated Solid-Phase Epitaxy of Silicon

Civale

Vastola

Nanver

et al. 2009

Journal of Elec Materi

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Mechanisms governing the aluminum-mediated solid-phase epitaxy of Si on patterned crystalline Si substrates have been identified by studying the deposited material as a function of growth conditions when varying parameters such as temperature, growth time, and layer-stack properties. Early growth stages can be discerned as first formation of ''free'' Si at the Al/a-Si interface, then diffusion of Si along the Al grain boundaries, nucleation at the Si substrate surface, nuclei rearrangement, and finally crystal growth. The acquired understanding is applied to control the selectivity and completeness of single-crystal growth in various sizes of contact windows to the Si substrate.

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Section: Influence Of the Dielectric Surface Propertiesmentioning

confidence: 99%

On the Mechanisms Governing Aluminum-Mediated Solid-Phase Epitaxy of Silicon

Civale

Vastola

Nanver

et al. 2009

Journal of Elec Materi

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“…l eff is the effective * For more details on waveguides, their structure and the terminology used please refer to Section 2, Figs. 2-4, and [7,8,9,17,20,28]. length of the detection window and is defined as the length in absence of channel narrowing.…”

Section: Design Of the Fluidic Channelsmentioning

confidence: 99%

Monolithic integration of optical waveguides for absorbance detection in microfabricated electrophoresis devices

et al. 2001

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The fabrication and performance of an electrophoretic separation chip with integrated optical waveguides for absorption detection is presented. The device was fabricated on a silicon substrate by standard microfabrication techniques with the use of two photolithographic mask steps. The waveguides on the device were connected to optical fibers, which enabled alignment free operation due to the absence of free-space optics. A 750 microm long U-shaped detection cell was used to facilitate longitudinal absorption detection. To minimize geometrically induced band broadening at the turn in the U-cell, tapering of the separation channel from a width of 120 down to 30 microm was employed. Electrical insulation was achieved by a 13 microm thermally grown silicon dioxide between the silicon substrate and the channels. The breakdown voltage during operation of the chip was measured to 10.6 kV. A separation of 3.2 microM rhodamine 110, 8 microM 2,7-dichlorofluorescein, 10 microM fluorescein and 18 microM 5-carboxyfluorescein was demonstrated on the device using the detection cell for absorption measurements at 488 nm.

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“…Many methods have been explored for the detection of miRNAs (Deng, et al, 2014;Degliangeli, et al, 2014;Roy, et al, 2011;Driskell, et al, 2008), but they are mostly too expensive and time consuming, requiring specialised laboratory equipments, and tedious incubation steps (Wen et al, 2012). Research has also been carried out with implementing silicon nanowire technology and some progresses has been made (Qavi, et al, 2011;Densmore, et al, 2009;Pandraud,et al, 2000;Ymeti, et al, 2005;Zhang, 2013). The development of "lab on a chip" photonic biosensors with high sensitivity of detection, capable of detecting disease-associated miRNAs, would be beneficial as an effective tool for the early-stage diagnosis of various disesases, especially cancers, as miRNAs are well preserved in various human specimens, including urine (Waber et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Photonic biosensor chip for early-stage cancer diagnosis

Najeeb

Zhang

Mellor

et al. 2015

2015 17th International Conference on Transparent Optical Networks (ICTON)

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This paper introduces a general design of a silicon wire "lab on a chip" photonic biosensor for medical diagnosis application, especially for early-stage cancer diagnosis. The sensitivity of detection of the biosensors developed is at least 10-100 times more sensitive than that of current commercial biosensors. KeywordsSilicon wire evanescent field biosensor; "Lab on a chip"; cancer early-stage diagnosis; sensitivity of detection; label-free detection; real time detection; multi-analytes' parallel detection.

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Evanescent wave sensing: new features for detection in small volumes

Cited by 61 publications

References 13 publications

On the Mechanisms Governing Aluminum-Mediated Solid-Phase Epitaxy of Silicon

On the Mechanisms Governing Aluminum-Mediated Solid-Phase Epitaxy of Silicon

Monolithic integration of optical waveguides for absorbance detection in microfabricated electrophoresis devices

Photonic biosensor chip for early-stage cancer diagnosis

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