Evaluation value of neutrophil gelatinase‐associated lipocalin for the renal dysfunction of patients with chronic kidney disease: A meta‐analysis

Guo, Lulu; Zhao, Yaya; Yong, Zhenzhu; Zhao, Weihong

doi:10.1002/agm2.12033

Cited by 9 publications

(14 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27 With regard to NGAL, the NGAL is increased significantly in the CKD patients in comparison with controls. This result is supported by another study (Guo et al, 2018) in that NGAL can reflect the entity of renal impairment and be considered as a risk marker for the progression of chronic kidney diseases. 28 Regarding MCP-1, it was significantly augmented in patients with CKD compared to controls.…”

Section: Discussionsupporting

confidence: 76%

“…This result is supported by another study (Guo et al, 2018) in that NGAL can reflect the entity of renal impairment and be considered as a risk marker for the progression of chronic kidney diseases. 28 Regarding MCP-1, it was significantly augmented in patients with CKD compared to controls. In line with this study, other researches showed that MCP-1 levels increased in chronic kidney diseases in children 29 and adults 30 .…”

Section: Discussionsupporting

confidence: 76%

See 1 more Smart Citation

Measurement of Inflammation-Related Biomarkers in Different Chronic Kidney Diseases in Humans: Role of Aging and Gender?

Ahmad

Ajeel

Aldabbagh

2021

imjm

View full text Add to dashboard Cite

INTRODUCTION: Chronic kidney disease (CKD) is a worldwide health problem which becomes a substantial emerging cause of morbidity. The inflammation can be resulted via different mechanisms in different kidney diseases including the imbalance of proinflammatory/anti-inflammatory biomarkers levels. This study aimed to measure the level of physiological bioactive substances as inflammation-related biomarkers in different CKD and to investigate whether gender or aging is critical in these measurements. MATERIALS AND METHODS: 84 persons (19 healthy, 29 chronic glomerulonephritis, 26 diabetic nephropathy, 6 benign nephrosclerosis, 4 lupus nephritis) were enrolled in this study. The inflammation progression degree in CKD was estimated by measuring the plasma level of neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein 1 (MCP1), and clusterin (CLU) using ELISA. Serum total protein, urea and creatinine were measured using an automatic analyzer. RESULTS: Plasma level of urea and creatinine was increased while total protein level was decreased in all the patients compared to control participants. The level of NGAL, MCP1 and CLU was significantly increased in all the kidney diseases compared to controls. In addition, there were no differences in the level of inflammation-related markers between women and men. Moreover, the levels of inflammatory markers were increased in the kidney diseases regardless of the age difference. CONCLUSIONS: This study showed that the physiological bioactive substances NGAL, MCP1 and CLU can be increased in renal pathologies and considered as good indicators of progression of inflammation in chronic kidney diseases, with no role of gender and age in their increment plasma levels.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 76%

Measurement of Inflammation-Related Biomarkers in Different Chronic Kidney Diseases in Humans: Role of Aging and Gender?

Ahmad

Ajeel

Aldabbagh

2021

imjm

View full text Add to dashboard Cite

show abstract

“…Serum neutrophil gelatinase-associated lipocalin (NGAL) has been shown to be an early predictor of kidney injury as it is released from tubular epithelium to distal nephrons after toxic or ischaemic injury has been afflicted [ 38 ]. In addition, NGAL is also expressed by neutrophils, epithelial cells, liver, and atherosclerotic plaques [ 39 ]. Kidney injury molecule-1 (KIM-1), an indicator of renal tubular damage, is released from proximal tubules.…”

Section: Discussionmentioning

confidence: 99%

The Role of RIPC in Preventing Organ Damage, Inflammation, and Oxidative Stress during Lower Limb DSA: A Randomised Controlled Trial

Kuusik

Kasepalu

Zilmer

et al. 2021

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Objective. Diagnostic digital subtraction angiography (DSA) and DSA with percutaneous transluminal angioplasty (DSA-PTA) are common procedures for diagnosing and treating symptomatic lower extremity arterial disease (LEAD). However, organ damage following DSA and DSA-PTA is often underrecognised and hence undiagnosed. To reduce the risk induced by invasive procedures in symptomatic LEAD patients, the method of remote ischemic preconditioning (RIPC) has been suggested. The aim of the current study was to assess the effect of RIPC intervention on the organ damage markers profile, oxidative stress, and inflammation biomarkers in LEAD patients undergoing DSA and DSA-PTA procedure. Methods. The RIPC intervention was performed by inflating a standard blood pressure cuff on the patient’s upper arm to 200 mmHg for 5 minutes four times with 5-minute perfusion between each cycle. The sham intervention was performed similarly, but the cuff was inflated to 20 mmHg. Changes in the cardiac and renal damage biomarkers’ profile, oxidative stress, and inflammation biomarkers were recorded before and 24 hours after DSA or DSA-PTA. Results. A total of 111 (RIPC 54, sham 57) patients with symptomatic LEAD scheduled for endovascular procedure were randomised, and 102 patients (RIPC 47, sham 55) completed the study protocol. RIPC significantly limited the increase of adiponectine levels after DSA and DSA-PTA, compared to sham intervention ( p = 0.020 ), but CK-MB levels were markedly lower in the sham group ( p = 0.047 ) after procedure. There was no significant difference between the RIPC and the sham group in mean changes in hs-troponin-T ( p = 0.25 ), NT-proBNP ( p = 0.24 ), creatinine ( p = 0.76 ), eGFR ( p = 0.61 ), urea ( p = 0.95 ), beta-2-microglobuline ( p = 0.34 ), or cystatine C ( p = 0.24 ) levels. Conclusion. In this controlled clinical study, RIPC failed to improve the profile of renal and cardiac biomarkers in patients with LEAD periprocedurally. RIPC significantly limits the rise in adiponectin levels and may influence the decrease of CK-MB levels 24 hours after endovascular procedure.

show abstract

“…The results of NGAL and KIM-1 examinations in chronic kidney disease as markers of its development are controversial [12,17,30]. Seibert et al in adult patients diagnosed for CKD in the course of the following diseases: diabetes mellitus, hypertensive nephropathy, glomerulonephritis and autosomal dominant polycystic kidney disease, did not confirm the better usefulness of NGAL and KIM-1as prognostic factors in comparison with standard albuminuria [12].…”

Section: Discussionmentioning

confidence: 99%

Urine NGAL and KIM-1: tubular injury markers in acute lymphoblastic leukemia survivors

Latoch

Konończuk

Taranta-Janusz

et al. 2020

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

Introduction Nephrotoxicity is a potential adverse effect of anticancer treatment in childhood. Cytostatics, abdominal radiotherapy, total body irradiation (TBI) and some agents used in supportive care may induce acute kidney injury (AKI) or lead to chronic kidney disease (CKD). The aim of this study was to test the hypothesis whether urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are increased in acute lymphoblastic leukemia (ALL) survivors. Method The study cohort consisted of 86 patients (42 females) previously treated for ALL. The median time after cessation of treatment was 6.55 (IQR: 1.96–9.93) years and median age at the time of study: 12 (IQR: 6.76–16.00). The control group included 53 healthy peers. Immunoenzymatic ELISA commercial kits were used to measure urine KIM-1 and NGAL levels. Results The median levels of urine uNGAL (p < 0.05), uNGAL/creatinine (cr.) ratio (p < 0.0001) and uKIM-1/creatinine ratio (p < 0.0001) were significantly higher in ALL survivors in comparison with healthy controls. Female patients had significantly higher levels of NGAL and NGAL/cr. than males (mean 8.42 ± 7.1 vs. 4.59 ± 4.5 ng/mL and 86.57 ± 77 vs. 37.7 ± 37 ng/mg, respectively; p < 0.01). Of all the study participants, 11 (13%) presented eGFR below 90 mL/min/1.73 m2. The NGAL/cr. ratio seemed to be the best predictor of decreased eGFR (AUC = 0.65). The cumulative dose of methotrexate and cyclophosphamide did not predict the values of the urine NGAL, NGAL/cr., KIM-1/cr. and eGFR. Five years after the end of treatment, the patients had higher levels of uKIM-1 (1.02 ± 0.8 vs. 0.62 ± 0.6 ng/mL, p < 0.01), uNGAL (7.9 ± 6.7 vs. 4.6 ± 5 ng/mL, p < 0.01) and lower eGFR (114 ± 29 vs. 134 ± 35 mL/min/1.73 m2, p < 0.01) in comparison with ALL survivors with the observation period of less than 5 years. Conclusion We demonstrated that ALL survivors have higher levels of urine NGAL, NGAL/cr. and uKIM-1/cr. ratio as compared to the control group. Further long-term follow-up studies are necessary to assess the significance of the NGAL and KIM-1 and their relationship to kidney damage after anticancer treatment in childhood.

show abstract

Evaluation value of neutrophil gelatinase‐associated lipocalin for the renal dysfunction of patients with chronic kidney disease: A meta‐analysis

Cited by 9 publications

References 78 publications

Measurement of Inflammation-Related Biomarkers in Different Chronic Kidney Diseases in Humans: Role of Aging and Gender?

Measurement of Inflammation-Related Biomarkers in Different Chronic Kidney Diseases in Humans: Role of Aging and Gender?

The Role of RIPC in Preventing Organ Damage, Inflammation, and Oxidative Stress during Lower Limb DSA: A Randomised Controlled Trial

Urine NGAL and KIM-1: tubular injury markers in acute lymphoblastic leukemia survivors

Contact Info

Product

Resources

About