2018
DOI: 10.1002/agm2.12033
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Evaluation value of neutrophil gelatinase‐associated lipocalin for the renal dysfunction of patients with chronic kidney disease: A meta‐analysis

Abstract: ObjectiveThe role of neutrophil gelatinase‐associated lipocalin (NGAL) for the evaluation of renal function in chronic kidney disease (CKD) has not yet to be determined. We aimed to perform a meta‐analysis exploring the correlation between NGAL and glomerular filtration rate (GFR) in CKD patients, and to further identify factors affecting NGAL's performance.MethodsStudies dated before November 2017 were retrieved from PubMed, Embase, Web of Science, and the Cochrane Library. A total of 28 relevant studies (inv… Show more

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Cited by 9 publications
(14 citation statements)
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References 78 publications
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“…27 With regard to NGAL, the NGAL is increased significantly in the CKD patients in comparison with controls. This result is supported by another study (Guo et al, 2018) in that NGAL can reflect the entity of renal impairment and be considered as a risk marker for the progression of chronic kidney diseases. 28 Regarding MCP-1, it was significantly augmented in patients with CKD compared to controls.…”
Section: Discussionsupporting
confidence: 76%
See 1 more Smart Citation
“…27 With regard to NGAL, the NGAL is increased significantly in the CKD patients in comparison with controls. This result is supported by another study (Guo et al, 2018) in that NGAL can reflect the entity of renal impairment and be considered as a risk marker for the progression of chronic kidney diseases. 28 Regarding MCP-1, it was significantly augmented in patients with CKD compared to controls.…”
Section: Discussionsupporting
confidence: 76%
“…This result is supported by another study (Guo et al, 2018) in that NGAL can reflect the entity of renal impairment and be considered as a risk marker for the progression of chronic kidney diseases. 28 Regarding MCP-1, it was significantly augmented in patients with CKD compared to controls. In line with this study, other researches showed that MCP-1 levels increased in chronic kidney diseases in children 29 and adults 30 .…”
Section: Discussionsupporting
confidence: 76%
“…Serum neutrophil gelatinase-associated lipocalin (NGAL) has been shown to be an early predictor of kidney injury as it is released from tubular epithelium to distal nephrons after toxic or ischaemic injury has been afflicted [ 38 ]. In addition, NGAL is also expressed by neutrophils, epithelial cells, liver, and atherosclerotic plaques [ 39 ]. Kidney injury molecule-1 (KIM-1), an indicator of renal tubular damage, is released from proximal tubules.…”
Section: Discussionmentioning
confidence: 99%
“…The results of NGAL and KIM-1 examinations in chronic kidney disease as markers of its development are controversial [12,17,30]. Seibert et al in adult patients diagnosed for CKD in the course of the following diseases: diabetes mellitus, hypertensive nephropathy, glomerulonephritis and autosomal dominant polycystic kidney disease, did not confirm the better usefulness of NGAL and KIM-1as prognostic factors in comparison with standard albuminuria [12].…”
Section: Discussionmentioning
confidence: 99%