Evaluation ofreginal liver function by gadolinium-EOB-DTPA enhanced MR imaging

Shimizu, Junichiro; Dono, Keizo; Gotoh, Mitsukazu; Hasuike, Yasunori; Kim, T.; Murakami, Takamichi; Sakon, Masato; Umeshita, K.; Nagano, Hisato; Nakamori, Shiro; Kato, Naoki; Miyazawa, Tomotaka; Nakamura, Haruki; Monden, Morito

doi:10.1016/s0016-5085(98)85448-6

Cited by 19 publications

(26 citation statements)

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“…Hepatocyte-phase gadoxetate disodiumenhanced MRI can be used to measure hepatocyte function [58][59][60] . One study shows that the contrast enhancement index (CEI = signal intensity post-enhancement/ signal intensity pre-enhancement) in gadoxetate disodium-enhanced MRI more accurately correlated with hepatic fibrosis staging than ADC values (CEI: r = -0.79, ADC: r = -0.43) [61] .…”

Section: Cut-offs Auroc Fibrosis Scorementioning

confidence: 99%

Prediction of liver cirrhosis, using diagnostic imaging tools

Yeom

Lee

Hoon

et al. 2015

WJH

106

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Early diagnosis of liver cirrhosis is important. Ultrasoundguided liver biopsy is the gold standard for diagnosis of liver cirrhosis. However, its invasiveness and sampling bias limit the applicability of the method. Basic imaging for the diagnosis of liver cirrhosis has developed over the last few decades, enabling early detection of morphological changes of the liver by ultrasonography (US), computed tomography, and magnetic resonance imaging (MRI). They are also accurate diagnostic methods for advanced liver cirrhosis, for which early diagnosis is difficult. There are a number of ways to compensate for this difficulty, including texture analysis to more closely identify the homogeneity of hepatic parenchyma, elastography to measure the stiffness and elasticity of the liver, and perfusion studies to determine the blood flow volume, transit time, and velocity. Amongst these methods, elastography using US and MRI was found to be slightly easier, faster, and able to provide an accurate diagnosis. Early diagnosis of liver cirrhosis using MRI or US elastography is therefore a realistic alternative, but further research is still needed.

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Section: Cut-offs Auroc Fibrosis Scorementioning

confidence: 99%

Prediction of liver cirrhosis, using diagnostic imaging tools

Yeom

Lee

Hoon

et al. 2015

WJH

106

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“…The same transporting mechanisms, i.e., the organic anion transporter, are considered to be responsible for uptake of gadoxetate disodium and ICG in hepatocytes (4,5); therefore, there is a possibility that gadoxetate disodium-enhanced MR imaging could be the basis of a useful method for quantitative evaluation of liver function similar to IGC clearance but with anatomic delineation of hepatic function, (6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Quantitative Evaluation of Liver Function with Use of Gadoxetate Disodium–enhanced MR Imaging

Yamada¹,

Hara²,

Li³

et al. 2011

Radiology

179

145

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Quantitative evaluation of liver function by use of gadoxetate disodium (Gd-EOB-DTPA)-enhanced MR Imaging. Manuscript type: Original research Advance in Knowledge:The liver function corresponding to the plasma disappearance rate of indocyanine green (ICG-PDR) can be estimated quantitatively (R = 0.87) from the signal intensities and the volumes of the liver and the spleen on gadoxetate disodium-enhanced MR images. Implications for Patient Care:1. Our study results suggest that (Gd-EOB-DTPA)-enhanced MR imaging of the liver may improve the early detection and treatment of liver diseases by evaluating anatomic and functional information on the liver by one examination.2. Gadoxetate disodium-enhanced MR imaging of the liver may allow quantitative estimation of segmental liver function. Summary statement:The liver function corresponding with ICG-PDR can be estimated quantitatively from the signal intensities and the volumes of the liver and spleen on gadoxetate disodium-enhanced MR images, which may improve the estimation of segmental liver reserve. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 Conclusion: The liver function correlating with ICG-PDR can be estimated quantitatively from the signal intensities and the volumes of the liver and spleen on gadoxetate disodiumenhanced MR images, which may improve the estimation of segmental liver function.

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“…Findings of the current study have shown that Gd-EOB-DTPA-enhanced MRI findings correlated with total bilirubin values and ICG-R15, and that this modality has potential for use in the same manner as scintigraphy as a prognostic staging system and as a parameter for the preoperative assessment of hepatectomy. Shimizu et al (25) identified regional ischemic damage in the rat right hepatic lobe during the hepatic uptake phase of Gd-EOB-DTPA-enhanced MRI. The ability of Gd-EOB-DTPA-enhanced MRI to evaluate regional liver function might contribute to the preoperative assessment of hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma

et al. 2012

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Abstract. Animal studies have demonstrated that liver function parameters affect the degree of liver enhancement by gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA). The present study prospectively investigated whether liver function parameters and liver damage scores similarly correlate with the degree of liver enhancement by Gd-EOB-DTPA in humans with hepatocellular carcinoma (HCC). A total of 41 patients (32 males, 9 females; mean age, 71.9 years; range, 38-86 years) with suspected HCC provided written, informed consent to undergo a Gd-EOB-DTPA (30 µmol/kg of body weight)-enhanced T1-gradient-echo (GRE) magnetic resonance imaging (MRI) study. The signal intensity of the liver parenchyma was quantified at various time points following injection of Gd-EOB-DTPA. We investigated the correlations between maximal relative enhancement (RE) values and liver function parameters, and liver damage scores. Correlations between parameters and maximum RE values were determined using the Student's t-test and univariate regression analyses. The effect of potential confounding factors was controlled by multiple stepwise regression analysis. Two-tailed values of p<0.05 were considered to indicate a statistically significant difference. The RE values were maximal in 8 and 33 patients at 20 and 30 min, respectively, following Gd-EOB-DTPA injection and did not significantly differ between respective liver damage scores. Univariate analyses revealed that maximal RE values were associated with serum aspartate aminotransferase, total bilirubin, albumin and 15-min indocyanine green retention rates. Multiple stepwise regression analyses revealed that serum albumin and total bilirubin remained independently significant. The degree of liver parenchyma enhancement by Gd-EOB-DTPA depends on liver function parameters in humans, as in animals. The results from this study suggest that Gd-EOB-DTPA has potential for use as a liver function test, and for providing a short examination time for liver MRI results in patients with normal liver function.

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Evaluation ofreginal liver function by gadolinium-EOB-DTPA enhanced MR imaging

Cited by 19 publications

References 0 publications

Prediction of liver cirrhosis, using diagnostic imaging tools

Prediction of liver cirrhosis, using diagnostic imaging tools

Quantitative Evaluation of Liver Function with Use of Gadoxetate Disodium–enhanced MR Imaging

Correlation of liver parenchymal gadolinium-ethoxybenzyl diethylenetriaminepentaacetic acid enhancement and liver function in humans with hepatocellular carcinoma

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