Evaluation of wound healing activities of kefir products

Huseini, H Fallah; Rahimzadeh, Golnar; Fazeli, Mohammad Reza; Mehrazma, Mitra; Salehi, Mitra

doi:10.1016/j.burns.2011.12.005

Cited by 114 publications

(88 citation statements)

References 23 publications

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“…Moreover, the results of other studies on the effects of local application of kefir grains, the mixtures of probiotic organisms, on the skin wounds indicated that kefir grains in addition to prevention of bacterial infection of the wounds may accelerate the healing processes of the wounds (10,11). Although, the overall conclusion of the current study is that the topical use of L. rhamnosus (ATCC 7469) on the burn wounds may have some positive effects on the healing processes of the wounds; but, there are some limitations in this study.…”

Section: Resultsmentioning

confidence: 99%

“…The functions and properties of probiotic bacteria are very specific; therefore, it is said that they have species or even strain-dependent effects (6,7). Previous studies on the effects of topical treatment of wounds with some strains of lactic acid bacteria on the healing process have shown some promising results (8)(9)(10)(11). L. rhamnosus (ATCC 7469) is among the lactic acid bacteria that its application is in the trial stage.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Lactobacillus rhamnosus (ATCC 7469) ointment on second-degree burn wound in Wistar rat

Barzegari

Hashemzaei

Alihemmati

et al. 2018

JBRMS

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Lactobacillus rhamnosus (ATCC 7469) ointment on second-degree burn wound in Wistar rat

Barzegari

Hashemzaei

Alihemmati

et al. 2018

JBRMS

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“…For example, kefir is good for the enhancement of the immune system, digestive health, the clinical treatment of metabolic diseases, hypertension, ischemic heart disease (IHD), and allergies. However, it has antimicrobial, antitumor, antiviral, antimutagenic, antiinflammatory and antioxidant effects [7]- [13].…”

mentioning

confidence: 99%

The Antioxidative Capacity of Kefir Produced from Goat Milk

Yilmaz‐Ersan¹,

Özcan²,

Akpinar‐Bayizit³

et al. 2016

IJCEA

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Abstract-In this present study, the antioxidant properties of kefir produced from goat milk with kefir grains were investigated. The antioxidant capacity of kefir was evaluated by assessing the DPPH (2,2-Diphenyl-1-picrylhydrazyl), the ABTS-based method [2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid)] radical-scavenging activity and ferric reducing antioxidant power (FRAP) at different stages of fermentation and storage period. Generally, the antioxidant capacity of goat milk-kefir samples was mainly dependent on the fermentation and storage period and good stability in DPPH, ABTS and FRAPS assays. During fermentation and storage, the total phenolic content in samples demonstrated significantly decreased.

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“…The beneficial effect of microflora in the gastrointestinal tract supports the use of probiotic [17]. Probiotic in the process of wound healing has been used by the researchers with the promising result [18], [19]. Our research aims to analyze the role of L.plantarum on the secretion of some cytokines resulted from the culture of macrophages and fibroblasts in vitro.…”

Section: Resultsmentioning

confidence: 99%

The Role of L. plantarum as an Immunomodulator Secretion of Transforming Growth Factor-Î²1, Transforming Growth Factor-Î²3, and Interferon-Î± Macrophages and Dermal Fibroblasts

Shintawati

Sudigdoadi²,

Madjid³

et al. 2017

AJAS

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This research aims to see the effect of L.plantarum in modulating the secretion of Transforming Growth Factor-TGFÎ²1, TGFÎ²3 macrophages and fibroblasts, Interferon-IFNÎ± macrophages, and to analyze the possibility of L.plantarum potency in supporting the process of scarless wound healing. The culture of peritoneal macrophages was treated with L.plantarum for 24 hours, while another macrophage was S.aureus stimulated for 6 hours before treatment of L.plantarum for 24 hours. The formed supernatant was separated and centrifuged to serve as a treatment on the culture of rat dermal fibroblasts for 24 hours. The supernatant was then separated and centrifuged; its cytokine level was measured with enzyme-linked immunosorbent assay-ELISA. Treatment of L.plantarum with medium and high doses increased the secretion of IFNa macrophages compared with the control; all L.plantarum doses can stimulate the secretion of TGFÎ²1 fibroblast and TGFÎ²3 macrophage significantly, but it does not affect the secretion of TGFÎ²1 macrophages. It can be concluded that L.plantarum increased the secretion of IFNÎ± macrophages higher than the treatment preceded by S.aureus stimulation. The secretion of TGFÎ²1 fibroblasts and TGFÎ²3 fibroblasts also increased, but it was not as high as L.plantarum treatment stimulated by S.aureus. Therefore, the application of L.plantarum to support the process of wound healing, prophylactic of the excessive scar and fibrosis can be researched further.

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Evaluation of wound healing activities of kefir products

Cited by 114 publications

References 23 publications

Effects of Lactobacillus rhamnosus (ATCC 7469) ointment on second-degree burn wound in Wistar rat

Effects of Lactobacillus rhamnosus (ATCC 7469) ointment on second-degree burn wound in Wistar rat

The Antioxidative Capacity of Kefir Produced from Goat Milk

The Role of <i>L. plantarum</i> as an Immunomodulator Secretion of <i>Transforming Growth Factor</i>-Î²1, <i>Transforming Growth Factor</i>-Î²3, and <i>Interferon</i>-Î± Macrophages and Dermal Fibroblasts

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