Evaluation of vinpocetine as a therapy in patients with sensorineural hearing loss: A phase II, open-label, single-center study

Gutiérrez-Farfán, Ileana; Reyes-Legorreta, Celia; Solís-Olguín, Mauricio; Alatorre-Miguel, Efrén; Verduzco-Mendoza, Antonio; Durand-Rivera, Alfredo

doi:10.1016/j.jphs.2021.01.010

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Preliminary studies have examined the potential beneficial effects of vinpocetine against memory loss, cancer, and Alzheimer's disease [134,135]. A clinical study high-lighted its effect in treating acquired sensorineural hearing loss and improving hearing [136]. Further, several clinical studies have shown that ginseng reduces tinnitus symptoms and improves the hearing threshold in people with sensorineural hearing loss [137,138].…”

Section: Mediterranean Dietmentioning

confidence: 99%

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Chen

Tan

et al. 2022

Nutrients

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Background: The world’s age-related health concerns continue to rise. Audio-vestibular disorders, such as hearing loss, tinnitus, and vertigo, are common complaints in the elderly and are associated with social and public health burdens. Various preventative measures can ease their impact, including healthy food consumption, nutritional supplementation, and lifestyle modification. We aim to provide a comprehensive summary of current possible strategies for preventing the age-related audio-vestibular dysfunction. Methods: A PubMed, Embase, and Cochrane review databases search was conducted to identify the relationship between diet, lifestyle, and audio-vestibular dysfunction. “Diet,” “nutritional supplement,” “lifestyle,” “exercise,” “physical activity,” “tinnitus,” “vertigo” and “age-related hearing loss” were used as keywords. Results: Audio-vestibular dysfunction develops and progresses as a result of age-related inflammation and oxidative stress. Diets with anti-inflammatory and antioxidant effects have been proposed to alleviate this illness. A high-fat diet may induce oxidative stress and low protein intake is associated with hearing discomfort in the elderly. Increased carbohydrate and sugar intake positively correlate with the incidence of audio-vestibular dysfunction, whereas a Mediterranean-style diet can protect against the disease. Antioxidants in the form of vitamins A, C, and E; physical activity; good sleep quality; smoking cessation; moderate alcohol consumption; and avoiding noise exposure are also beneficial. Conclusions: Adequate diet or nutritional interventions with lifestyle modification may protect against developing audio-vestibular dysfunction in elderly individuals.

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Section: Mediterranean Dietmentioning

confidence: 99%

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Chen

Tan

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“… 45 It has an excellent safety profile with low toxicity in humans, and has shown anti-inflammatory action in both laboratory settings and living organisms through several pathways, notably via diminished NF-κB and TNF-α expression. 45 , 72 Furthermore, VNP inhibits TLR-4 and the transcriptional process of NF-κB, thus restricting the production of chemotactic cytokines. 73 , 74 Because of its recognized safety, VNP has recently been explored for its specific medicinal properties and modes of action in many different types of cells and disease prototypes.…”

Section: Introductionmentioning

confidence: 99%

Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis

Salman,

Alzubaidy,

Abbas

et al. 2024

Journal of Taibah University Medical Sciences

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Evaluation of vinpocetine as a therapy in patients with sensorineural hearing loss: A phase II, open-label, single-center study

Cited by 2 publications

References 22 publications

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Effects of Diet and Lifestyle on Audio-Vestibular Dysfunction in the Elderly: A Literature Review

Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis

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