Evaluation of ultrasonic vocalizations in a neurodevelopmental model of schizophrenia during the early life stages of rats

Potasiewicz, Agnieszka; Hołuj, Małgorzata; Piotrowska, Diana; Zajda, Katarzyna; Wójcik, Michał J.; Popik, Piotr; Nikiforuk, Agnieszka

doi:10.1016/j.neuropharm.2018.11.023

Cited by 23 publications

(26 citation statements)

References 86 publications

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“…In the current study, extending previous analyses (Kisko et al., 2020), prominent sex differences were observed in 50‐kHz USV emission rates during rough‐and‐tumble play. This is in line with a number of recent studies reporting that juvenile males emit more 50‐kHz USV than females during playful social interactions (Himmler et al., 2014; Lukas & Wöhr, 2015; Panksepp & Burgdorf, 2003; Potasiewicz et al., 2019). Here, we now not only confirm this finding but also go further to show that this is true during periods of play as well as nonplay periods.…”

Section: Discussionsupporting

confidence: 90%

“…With regards to specific differences in acoustic parameters and subtype profiles of 50‐kHz USV during rough‐and‐tumble play, however, the literature available is scant. One recent study found that, in line with previous reports, males indeed emit more 50‐kHz USV during rough‐and‐tumble play than females (Potasiewicz et al., 2019). When examining specific 50‐kHz USV acoustic parameters between sexes, males were further found to emit 50‐kHz USV with a higher level of frequency modulation than females and to produce a higher proportion of frequency‐modulated 50‐kHz USV and fewer flat 50‐kHz USV (Potasiewicz et al., 2019).…”

Section: Introductionsupporting

confidence: 83%

“…One recent study found that, in line with previous reports, males indeed emit more 50‐kHz USV during rough‐and‐tumble play than females (Potasiewicz et al., 2019). When examining specific 50‐kHz USV acoustic parameters between sexes, males were further found to emit 50‐kHz USV with a higher level of frequency modulation than females and to produce a higher proportion of frequency‐modulated 50‐kHz USV and fewer flat 50‐kHz USV (Potasiewicz et al., 2019). To our knowledge, only one other study examined differences between 50‐kHz USV subtypes within rough‐and‐tumble play, yet there were no significant sex differences found, and additional acoustic parameters, such as call duration or peak frequency, were not evaluated (Himmler et al., 2014).…”

Section: Introductionsupporting

confidence: 83%

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Sex differences in the acoustic features of social play‐induced 50‐kHz ultrasonic vocalizations: A detailed spectrographic analysis in wild‐type Sprague–Dawley and Cacna1c haploinsufficient rats

Kisko

Schwarting

Wöhr

2020

Developmental Psychobiology

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Sexual dimorphisms are widespread in the animal kingdom. At the behavioral level, there is evidence for sex differences in social play behavior. In rats, males typically engage more in rough‐and‐tumble play than females. One prominent component of the rough‐and‐tumble play repertoire in rats is the emission of 50‐kHz ultrasonic vocalizations (USV). Such 50‐kHz USV reflect the rewarding nature of play and serve as socioaffective signals. Here, we provide evidence for sexual dimorphisms within rough‐and‐tumble play‐induced 50‐kHz USV in juvenile rats. Specifically, females displayed reduced 50‐kHz USV emission during playful interactions. This reduction was associated with changes in 50‐kHz USV emission rates and subtype profiles during specific rough‐and‐tumble components, i.e., pinning, wrestling, and chasing, as well as differences in acoustic parameters. Interestingly, sex differences were modulated by Cacna1c, a gene strongly implicated in major neuropsychiatric disorders, often characterized by prominent sex biases, most notably autism. Specifically, Cacna1c haploinsufficiency affected the emission of 50‐kHz USV during rough‐and‐tumble play in female rats and we provide evidence supporting the notion that such effects of Cacna1c haploinsufficiency are driven by male‐typical features of 50‐kHz USV emission. This is in line with the hypermasculinized social play repertoire previously observed in juvenile Cacna1c haploinsufficient females.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 83%

Section: Introductionsupporting

confidence: 83%

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Sex differences in the acoustic features of social play‐induced 50‐kHz ultrasonic vocalizations: A detailed spectrographic analysis in wild‐type Sprague–Dawley and Cacna1c haploinsufficient rats

Kisko

Schwarting

Wöhr

2020

Developmental Psychobiology

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“…The rats’ vocalisations during the open field and social interaction tests were recorded as previously described by Potasiewicz et al . 57 using an ultrasound microphone (CM16/CMPA, Avisoft Bioacoustics, Berlin, Germany) suspended 25 cm above the floor of the test area (tickling and SP test). The acoustic data were recorded using Version 1.5 Raven Pro Interactive Sound Analysis Software (The Cornell Lab of Ornithology Bioacoustics Research Program, Ithaca, NY, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Based on the acoustic call features, we also manually divided the calls into the following general types: short calls, flat calls with a near-constant frequency and frequency-modulated calls ( 57 , detailed description in Table 1). The frequency modulated calls were subsequently classified as: the trills, one-component calls (predominantly complex calls and also ramp and inverted-U calls) and multi-component calls (predominantly multi-step calls and also step up, step down and composite calls) 4,7 .…”

Section: Methodsmentioning

confidence: 99%

Serotonin transporter deficiency alters socioemotional ultrasonic communication in rats

Golebiowska

Hołuj

Potasiewicz

et al. 2019

Sci Rep

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It has been widely established that serotonin plays important role in the regulation of emotional and social behaviour. Rodents with a genetic deletion of the serotonin reuptake transporter (SERT) are used as a model to study lifelong consequences of increased extracellular 5‐HT levels due to its impaired reuptake. SERT knock-out (SERT-KO) mice and rats consistently showed anxiety-like symptoms and social deficits. Nevertheless, the impact of SERT deletion on socioemotional ultrasonic communication has not been addressed. Here we investigated the impact of lifelong serotonin abundance on ultrasonic vocalisation accompanying social interactions and open field exploration in rats. SERT-KO rats displayed reduced overall duration of social contacts, but increased time spent on following the conspecific. The altered pattern of social behaviour in SERT-KO rats was accompanied by the structural changes in ultrasonic vocalisations, as they differed from their controls in distribution of call categories. Moreover, SERT deletion resulted in anxiety-like behaviours assessed in the open field test. Their anxious phenotype resulted in a lower tendency to emit appetitive 50-kHz calls during novelty exploration. The present study demonstrates that genetic deletion of SERT not only leads to the deficits in social interaction and increased anxiety but also affects ultrasonic communication.

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Valproic acid exposure impairs ultrasonic communication in infant, adolescent and adult rats

Gzieło

Potasiewicz

Hołuj

et al. 2020

European Neuropsychopharmacology

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Evaluation of ultrasonic vocalizations in a neurodevelopmental model of schizophrenia during the early life stages of rats

Cited by 23 publications

References 86 publications

Sex differences in the acoustic features of social play‐induced 50‐kHz ultrasonic vocalizations: A detailed spectrographic analysis in wild‐type Sprague–Dawley and Cacna1c haploinsufficient rats

Sex differences in the acoustic features of social play‐induced 50‐kHz ultrasonic vocalizations: A detailed spectrographic analysis in wild‐type Sprague–Dawley and Cacna1c haploinsufficient rats

Serotonin transporter deficiency alters socioemotional ultrasonic communication in rats

Valproic acid exposure impairs ultrasonic communication in infant, adolescent and adult rats

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