Evaluation of trace elements and Malondialdehyde levels in type II diabetes mellitus

Kamal, Manal; Salem, Mona M; Kholousi, Naglaa; Ashmawy, K. R.

doi:10.1016/j.dsx.2009.07.007

Cited by 19 publications

(22 citation statements)

References 19 publications

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“…These results are consistent with the findings of Kamal et al .,[34] who stated that deficiency of trace elements may play a role in pathogenesis of DM. Furthermore, above findings may be attributed to the association of Mg deficiency with IR, carbohydrate intolerance, and dyslipidemia.…”

Section: Discussionsupporting

confidence: 93%

Study of lipid peroxidation, nitric oxide end product, and trace element status in type 2 diabetes mellitus with and without complications

Mishra

2017

Int J App Basic Med Res

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Background:Oxidative stress has become a real entity in etiopathogenesis of Type 2 diabetes mellitus (DM). It may result from steady flux of free radicals and lipid peroxides in vivo. Malondialdehyde (MDA) is a stable end product of lipid peroxidation. Accumulative evidences suggest that hyperglycemia in Type 2 DM can produce major changes in nitric oxide (NO) production as well as in its action. Alteration in metabolism of trace elements is also observed in DM.Objective:To evaluate oxidative stress, status of NO, and trace elements zinc (Zn) and magnesium (Mg) in type 2 DM and to correlate these parameters with disease process.Materials and Methods:Ninety-two cases with diabetes were included in the study, out of which 51 were type 2 DM without any complication and 41 were type 2 DM with complications. Fifty-one nondiabetic healthy controls from hospital staff were selected for the study. Blood samples were collected after an overnight fast for estimation of fasting plasma glucose, postprandial glucose, glycated hemoglobin (HbA1c), lipid profile, trace element status, MDA, and NO.Results:Study revealed a rise in MDA levels in both uncomplicated and complicated cases with diabetes (2.47 ± 0.53, 3.98 ± 0.42 nmol/ml, respectively) as compared to controls (1.43 ± 0.23 nmol/ml), which was statistically significant (P < 0.05). The mean levels of NO, Zn, and Mg were significantly lower in both the diabetic groups than the control group (P < 0.05). MDA showed a significant positive correlation with plasma glucose, lipid profile parameters (except high-density lipoprotein cholesterol), and significant negative correlation with Zn (r = −0.44, P < 0.05) and Mg (r = −0.31, P < 0.05). NO levels were correlated significantly with plasma glucose, dyslipidemia, and HbA1c (P < 0.05). The effects of glycemic status on trace element concentrations were evident from a significant negative correlation between Zn and Mg with fasting plasma glucose and HbA1c.Conclusion:Findings of the present study may establish the role of hyperglycemia, oxidative stress, impaired NO, and trace elements in pathogenesis and long-term vascular complications of type 2 DM.

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Section: Discussionsupporting

confidence: 93%

Study of lipid peroxidation, nitric oxide end product, and trace element status in type 2 diabetes mellitus with and without complications

Mishra

2017

Int J App Basic Med Res

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“…In addition in this study there 6 is highly negative correlation between serum selenium concentration and HbA1c in group II (Fig. (1)) this result agreed with Manal Kamal et al [45] in 2009 have found that highly negative correlation between serum selenium concentration and HbA1c while in 2009 Muhittin A Serdarrepoted et al [46] showed that there is no correlation between HbA1c and selenium. In conclusion, the levels of serum selenium are lower among diabetic patients with or without CVD than among healthy controls.…”

Section: ----------------------------------------supporting

confidence: 82%

Evaluation of Changes in Levels of Serum Selenium in Diabetic Pateints and in Diabetic Pateints with Cardiovascular Disease

Kasar¹

2011

JNUS

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Selenium, an essential micronutrient, may affect several cardiometabolic risk factors, such as glucose homeostasis and lipid concentrations. The aim of this study is to examin the relation between serum selenium concentrations with serum lipids in diabetic patients and in diabetic patients with cardiovascular diseases (CVD).A case control study conducted in the National Diabetes Center, College of Medicine at Al-Mustansiryia University. Fasting glucose, total cholesterol, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and very low density lipoprotein-cholesterol (VLDL-C), HbA1c and Serum selenium were determine. Diabetes mellitus (n=256) divided into tow groups, group I (n=156) diabetic patients and group II (n=100) diabetic patients complicated with CVD. Normal healthy subjects were taken as control (n= 100).In the present study a significant decrease in selenium levels was found in patients groups compared to control also there is decrease in selenium levels of diabetic patients with CVD (group II) compared with diabetic patients (group I). These findings indicate that the decrease in serum selenium was associated with elevated serum concentrations of fasting blood glucose, total cholesterol, LDL-C, VLDL-C, triacylglycerols and duration of diabetes. In general despite their classification according to sex or diabetes type highly negative correlations (p<0.0001) were found with linear regression equations between fasting serum selenium concentration and HbA1c in patients group II. In conclusion the significant reductions in the level of selenium in diabetic patients may be response on the developing t he diabetic to anther disease like CVD.

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“…Hasil mendapati bahawa tiada perbezaan yang signifi kan di antara paras kromium pada kuku dan rambut petani dengan status glukosa darah. Hasil kajian Kamal et al (2009) juga mendapati tiada perbezaan yang signifi kan antara paras kromium pada pesakit diabetes dengan kawalan. Namun begitu, hasil ini bertentangan dengan hasil kajian yang dilakukan oleh Ghosh et al (2002) yang mana mendapati bahawa aras kromium pada pesakit diabetis adalah rendah secara signifi kan berbanding kawalan.…”

Section: Perbincanganunclassified

Factors Affected Chromium Levels Among Farmers in District of Bachok and Pasir Puteh, Kelantan

Firdaus¹,

Ishak²,

Lubis³

et al. 2014

JSKM

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Evaluation of trace elements and Malondialdehyde levels in type II diabetes mellitus

Cited by 19 publications

References 19 publications

Study of lipid peroxidation, nitric oxide end product, and trace element status in type 2 diabetes mellitus with and without complications

Study of lipid peroxidation, nitric oxide end product, and trace element status in type 2 diabetes mellitus with and without complications

Evaluation of Changes in Levels of Serum Selenium in Diabetic Pateints and in Diabetic Pateints with Cardiovascular Disease

Factors Affected Chromium Levels Among Farmers in District of Bachok and Pasir Puteh, Kelantan

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