Evaluation of Trabecular Microarchitecture of Normal Osteoporotic and Osteopenic Human Vertebrae

Cesar, R.; Boffa, R.S.; Fachine, Luiz Tadeu de Moura; Leivas, Tomaz Puga; Silva, A.M.H.; Pereira, César Augusto Martins; Reiff, R.B.M.; Rollo, João Manuel Domingos de Almeida

doi:10.1016/j.proeng.2013.05.087

Cited by 16 publications

(19 citation statements)

References 29 publications

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“…If the presence of muscular tissue were considered, the relative difference between these groups would probably be much higher. This decrease in bone mass was similar to other studies performed in human vertebrae (Cesar et al 2013) with osteopenia and osteoporosis, and in animals (Hsu et al 2016, Longo et al 2016). …”

Section: Discussionsupporting

confidence: 91%

“…The Percent Bone Volume parameter determines the ratio of bone volume within the Volume-of-Interest Object that is used to measure bone mass related to non-mineralized tissue of the sample (Cesar et al 2013, Hsu et al 2016, Longo et al 2017. In this study, the percentage in group G3 and G4 were higher for both trabecular bone and cortical bone compared to group G1 and G2.…”

Section: Discussionmentioning

confidence: 82%

“…Computerized microtomography is a modern laboratory methodology considered the gold standard examination for bone quality assessment (composition, resistance, and geometry) that also allows understanding etiopathology of diseases (Compston 2006, Vasilić et al 2009, Bouxsein et al 2010, Liu et al 2011, Ritman 2011, Syahrom et al 2011, Gregor et al 2012, Blok et al 2013, Cesar et al 2013, Paolillo 2013, Fernandes 2014, Paolillo et al 2014, Fuller et al 2015. Total porosity (Po (tot), %)of trabecular bone of groups G1, G2, G3, and G4 for Pantanal alligator (Caiman yacare) tibia.…”

Section: Discussionmentioning

confidence: 99%

“…However, the difference between groups with a balanced diet, G3 (without sun exposure) and G4 (0.480mm, with sun exposure), was 0.043mm, showing a similar pattern with Trabecular Number related to sun exposure factor. Several studies have demonstrated that osteopenic and osteoporotic bone present higher values for Trabecular Separation and lower values for Trabecular Numberand Trabecular Thickness when compared to normal bone (Cesar et al 2013, Hsu et al 2016, Longo et al 2016. Recent studies have demonstrated that the results in ovariectomized groups were inferior (Tb.Th and Tb.N) and superior (Tb.Sp), both statistically different from the control groups (Longo et al 2016, Hsu et al 2016.…”

Section: Trabecular Bone Analysismentioning

confidence: 99%

“…Computerized microtomography (μCT) is one assessment system widely used in bone evaluation (Ritman 2011, Syahrom et al 2011, Blok et al 2013, Cesar et al 2013, Paolillo 2013, Fernandes 2014, Paolillo et al 2014, and it is considered the gold standard examination for this purpose (Bouxsein et al 2010, Fuller et al 2015. Results from this exam are based on quantitative parameters for both cortical and trabecular bone (Klinck et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Bone quality evaluation of experimental osteometabolic disease in Pantanal alligators (Caiman yacare) by High Resolution Computerized Microtomography (μCT)

et al. 2018

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Computerized microtomography is the gold standard examination for the evaluation of the three-dimensional bone structure. This experiment was developed to evaluate the structure and bone quality of Caiman yacare with metabolic bone disease using high resolution computerized microtomography (μCT). The animals were distributed into four groups: G1 -hyperphosphatemic diet with sun exposure deprivation (n=4), G2 -hyperphosphatemic diet with sun exposure (n=4), G3 -balanced diet with sun exposure deprivation (n=4), and G4 -balanced diet with exposure to sunlight (n=4). The parameters for the trabecular bone (Trabecular Number, Trabecular Thickness, Trabecular Separation, Bone Pattern Factor, Fractal Dimension, Euler Number, Structural Model Index, Degree of Anisotropy, Eigenvalues 1, 2 and 3, and Centroides X, Y and Z), and cortical bone (Number of Closed Pores, Volume of Closed Pores, Surface of Closed Pores, Closed Porosity, Volume of Open Pores, Open Porosity and Total Porosity). The overall results showed that the structure and bone quality of group G3 and G4 were better than those of groups G1 and G2, and that the diet factor influenced more than the sun exposure factor. The computerized microtomography allowed to evaluate the quality of the cortical and trabecular bones of the Pantanal alligator tibia with osteometabolic disease. The diet and sun exposure factors influenced individually the results of the μCT parameters between the groups, demonstrating the functional and structural complexity. Thus, these parameters can contribute to the interpretation of the mechanical behavior of bones and correlate them with the risk of lesions and fractures associated with osteometabolic diseases.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Trabecular Bone Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bone quality evaluation of experimental osteometabolic disease in Pantanal alligators (Caiman yacare) by High Resolution Computerized Microtomography (μCT)

et al. 2018

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Ovariectomy and timing of impaired maxillary alveolar bone regeneration: An experimental study in rats

Kim

Lee

et al. 2020

Journal of Periodontology

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Background: The aim of this study was to seek the critical time for impairment of alveolar bone regeneration after ovariectomy (OVX) in rats. Methods: A total of 32 female rats were used. Test group rats were divided into a 2M group (n = 8), a 3M group (n = 8) and a 4M group (n = 8) according to the duration from OVX to defect creation. Bilateral OVX was performed in all test groups, and a sham operation was performed in the control group (n = 8). Drill-hole defects (1.5 mm diameter, 2 mm length) were created on both sides of the maxilla. All rats were euthanized 2 and 4 weeks after the surgery. Microcomputed tomographic (micro-CT), histological, and histomorphometric analyses and in vitro experiments were performed. Results: The 4M group showed significantly less new bone formation and a lower bone mineral density than the other groups in the micro-CT analysis. The histomorphometric analysis also revealed that the 4M group showed significantly less new bone formation than the control and 2M groups. The rats in the 4M group showed significantly higher alkaline phosphatase expression levels and a larger number of calcified nodules than rats in the other groups, whereas osteoclastic activity was significantly lower in the 4M group than in the other groups. Conclusions: The critical time for impairment of alveolar bone regeneration was 4 months after OVX in rats.

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Micro-CT–Based Bone Microarchitecture Analysis of the Murine Skull

Tan

Labrinidis

Williams

et al. 2021

Methods in Molecular Biology

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X-ray micro-computed tomography (micro-CT) imaging has important applications in microarchitecture analysis of cortical and trabecular bone structure. While standardized protocols exist for micro-CT-based microarchitecture assessment of long bones, specific protocols need to be developed for different types of skull bones taking into account differences in embryogenesis, organization, development, and growth compared to the rest of the body. This chapter describes the general principles of bone microarchitecture analysis of murine craniofacial skeleton to accommodate for morphological variations in different regions of interest.

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Evaluation of Trabecular Microarchitecture of Normal Osteoporotic and Osteopenic Human Vertebrae

Cited by 16 publications

References 29 publications

Bone quality evaluation of experimental osteometabolic disease in Pantanal alligators (Caiman yacare) by High Resolution Computerized Microtomography (μCT)

Bone quality evaluation of experimental osteometabolic disease in Pantanal alligators (Caiman yacare) by High Resolution Computerized Microtomography (μCT)

Ovariectomy and timing of impaired maxillary alveolar bone regeneration: An experimental study in rats

Micro-CT–Based Bone Microarchitecture Analysis of the Murine Skull

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