Evaluation of Toxicological and Standardization Parameters and Phytochemical Investigation of Ficus deltoidea Leaves

Amin

Evidence-Based Complementary and Alternative Medicine

et al. 2014

Ficus deltoidea Jack (Moraceae) has had a long history of use in traditional medicine among the Malays to alleviate and heal ailments such as sores, wounds, and rheumatism and as an after-birth tonic and an antidiabetic drug. Modern pharmacological studies demonstrated that this plant has a wide variety of beneficial attributes for human health. Despite its importance, a review of this species has not been published in the scientific literature to date. Here, we review and summarize the historic and current literature concerning the botany, traditional uses, phytochemistry, pharmacological effects, and toxicity of this wonder plant. This summary could be beneficial for future research aiming to exploit the therapeutic potential of this useful, medicinal species.

Section: Cytotoxicity Activitymentioning

confidence: 99%

Ficus deltoideaJack: A Review on Its Phytochemical and Pharmacological Importance

Amin

Evidence-Based Complementary and Alternative Medicine

et al. 2014

“…Scientific evidences have demonstrated the nutritional and medicinal properties of HS, yet there is no guaranteed safety on its use. This is because reports on investigations carried out on medicinal plants show that they could cause damage to vital organs of the body even when considered safe for consumption [9].…”

Section: Introductionmentioning

confidence: 99%

Histological and Biochemical Evaluation of the Kidney following Chronic Consumption of Hibiscus sabdariffa

Ukoha

Mbagwu

Ndukwe

et al. 2015

Advances in Biology

Hibiscus sabdariffa L. has been used traditionally as herbal medicine and has been documented to have a broad range of therapeutic effects. The present study aimed to investigate the effects of chronic administration of aqueous extract of flowers of Hibiscus sabdariffa on the histology of the kidney and some biochemical indices of renal function in male Wistar rats. Twenty (20) Wistar rats were randomly divided into four (4) groups of five rats each. The extract was administered orally in doses 200, 500, and 800 mg/kg body weight for 21 days. The kidney was harvested and processed histologically and blood samples were taken for biochemical assays. The histological results showed dose dependent pathological states and the biochemical analysis revealed a dose dependant variation in renal indices. These results suggest that chronic administration of aqueous extract of Hibiscus sabdariffa may be toxic to the kidney.

“…chemical drugs), drug tolerance, rise of the complications of the disease (despite careful management), and high financial implications imposed on society and individuals; the use of medicinal herbs and traditional medicine has become a priority globally (Zareiet al, 2015). Conversely, the widespread use and increasing popularity of herbal medicines does not guarantee their efficacy and safety (Shafaei, 2011).…”

Section: Issn: 2320-5407mentioning

confidence: 99%

Phytochemical Screening and Toxicological Study of the Aqueous Extract of Stem Bark of Mitragyna Inermis (Wild) O. Kundze (Rubiaceae), a Traditional Medicine Plant.

Sangare¹,

Ategbo²,

Attakpa³

et al. 2017

IJAR

Background:The use of plants gained widespread as well in developing countries as in developed countries for different purposes and both as mixture or single formula. That widespread use does not guarantee their safety and efficiency. The aim of the present study is to assess the phytochemistry and subacute toxicity of Mitragynainermis, an allegatednephroprotective properties plant acclimated in Benin. Methods: By complexion and/ or precipitation reactions, the different groups of secondary metabolites in these plants were highlighted. The crude aqueous extract of M. inermis has been force-fed to rats for seven days. They were observed for toxicity signs and some blood biochemical parameters have been evaluated before and after treatment. We used Microsoft excel and Minitab 1.6 to process data. Result: Different phytochemicals were found and crude aqueous extract of M. inermis doesn't induce toxicity signs on rats after sevenday force-feeding up to 2500 km/kg of body weight using oral route. Biochemical analysis shows a significant decrease in blood level of urea and creatinine up to 2500 km/kg of body weight. The significant increase in ALAT by D2 (1000 km/kg dose) and both in ALAT and ASAT by D3 (2500 km/kg dose) after 7 days is decreased and normalized during the observation period. Conclusion: Crude aqueous extract of M. inermis stem back is less toxic up to 2500 km/kg of body weight and should be taken during consecutively less than 7 days.