Evaluation of toxic effects with transition metal ions, EDTA, SBTI and acrylic polymers on Aedes aegypti (L., 1762) (Diptera: Culicidae) and Artemia salina (artemidae)

Arruda, Eduardo José de; Rossi, Ana Paula Leão; Porto, Karla Rejane de Andrade; Oliveira, Lincoln Carlos Silva de; Arakaki, Andréa Haruko; Scheidt, Gessiel Newton; Soccol, Carlos Ricardo

doi:10.1590/s1516-89132010000200012

Cited by 17 publications

(4 citation statements)

References 15 publications

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“…The synthesized Schiff base ligands and their respective metal complexes underwent in vitro analysis of larvicidal activity, following the methodology outlined in reference [20]. The mosquito larvae were obtained from aquatic habitats situated in Nagercoil, Kanyakumari District, using a receptacle with a wide aperture.…”

Section: In Vitro Analysis Of Larvicidal Activitymentioning

confidence: 99%

Synthesis and characterization of (E)-4-((anthracen-9-ylmethylene) amino)-N- (pyridin-2-yl) benzenesulfonamide and its metal complexes: Evaluation of potential against the colon cancer cell line COLO-205 and biological activity profiles

Jona,

Suja,

Suman

et al. 2023

Preprint

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The use of schiff base metal complexes has attracted considerable interest because of their wide-ranging applications in the fields of coordination chemistry and biological sciences. A straightforward simple condensation methodology with acid catalyst approaches was used to synthesize a (E)-4-((anthracen-9-ylmethylene)amino)-N-(pyridin-2-yl) benzenesulfonamide schiff base ligand. The followed by the synthesis of the metal–ligand complexes encompassed the coordination of the Schiff base ligand to the transition metal ion in an ethanolic medium. Subsequent structural characterization and their properties were predicted using spectroscopic and analytical techniques. Furthermore, we evaluated the biological properties exhibited by these complexes, with a specific emphasis on their potential applications as antimicrobial, anticancer, antioxidant, and enzyme inhibition agents. The findings derived from this investigation yield significant perspectives regarding the formulation and advancement of innovative metal– organic complexes that exhibit augmented therapeutic attributes.

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Section: In Vitro Analysis Of Larvicidal Activitymentioning

confidence: 99%

Synthesis and characterization of (E)-4-((anthracen-9-ylmethylene) amino)-N- (pyridin-2-yl) benzenesulfonamide and its metal complexes: Evaluation of potential against the colon cancer cell line COLO-205 and biological activity profiles

Jona,

Suja,

Suman

et al. 2023

Preprint

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“…Estudos recentes demonstraram que o íon cobre, quando complexado com o ácido etilenodiaminotetracético (EDTA) para formar o íon complexo [Cu (EDTA)] -2 , apresenta letalidade sobre larvas de terceiro ínstar de Aedes aegypti, cuja CL90, é de 127,5 mg L -1 (concentração de íon cobre equivalente a 12,8 mg L -1 ) (Arruda et al, 2010).…”

Section: +2unclassified

“…-2 livre e nanoencapsulado empregadas nos ensaios foram baseadas no trabalho de Arruda et al (2010) ) e imediatamente se fez a coleta de amostra de sangue por meio de punção cardíaca. Em seguida, a medula espinhal foi seccionada e realizada a retirada de brânquias e fígado, os quais, juntamente com o restante da carcaça foram imediatamente pesados, identificados e congelados em ultra-freezer (-80ºC) e depois em nitrogênio líquido para o processo de liofilização e quantificação do conteúdo de cobre por espectrometria de absorção atômica.…”

Section: As Concentrações Do [Cu(edta)]unclassified

Efeito Mutagênico do Edetato de Cobre ([Cu(EDTA)]-2) Livre e Nanoencapsulado em Camundongos e Peixes

Jacacobowski¹,

Zobiole²,

Padilha³

et al. 2013

Ecotoxicol. Environ. Contam.

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ResumoEstudos recentes demonstram que o cobre complexado com o ácido etilenodiaminotetracético, ([Cu(EDTA)] -2 ), apresenta letalidade sobre larvas de Aedes aegypti. Este composto pode ter uma liberação lenta e gradativa quando complexado em nanocápsulas de goma/gelatina/quitosana, o que pode limitar sua toxicidade para o ambiente. No entanto, a genotoxicidade do [Cu(EDTA)] -2 ainda não está totalmente elucidada. Para avaliar o potencial mutagênico do [Cu(EDTA)] -2 , analisamos a frequência de micronúcleos no sangue periférico de camundongos e peixes submetidos a [Cu(EDTA)] -2 livre e nanoencapsulado. A carcaça dos peixes foi avaliada por espectrometria de massa para quantificar o cobre tecidual. Em camundongos a frequência de micronúcleos nos animais expostos ao [Cu(EDTA)] -2 na forma livre foi significativamente maior em relação aos animais submetidos à forma nanoencapsulada. Em peixes, somente o [Cu(EDTA)] -2 livre foi capaz de induzir aumento na frequência de micronúcleos. A análise espectrométrica demonstrou acúmulo de íons cobre no fígado nos grupos de peixes estudados, com diferença significativa em relação ao grupo controle. Nas brânquias dos peixes não foram observadas diferenças na concentração de cobre entre os grupos e ainda, o conteúdo de cobre foi significativamente menor em relação ao encontrado no fígado. Os resultados sugerem que o [Cu(EDTA)] -2 livre pode induzir efeitos mutagênicos em mamíferos, porém o nanoencapsulamento parece conferir maior segurança ao produto devido a sua liberação mais lenta.Palavras-chave: Camundongos; Edetato de Cobre; Mutagenicidade; Nanocápsulas; Peixes; Teste do Micronúcleo. The mutagenic effect of the free and nanoencapsulated Cooper edetate in mice and fish AbstractRecent studies show that copper complexes with ethylenediaminetetraacetic acid ([Cu(EDTA)] -2 ), is lethal for Aedes aegypti larvae. This compound may have a controlled release when nanocapsules complex in gum/gelatin/chitosan, which may limit their toxicity to the environment. However, the genotoxicity of [Cu(EDTA)] -2 is not fully elucidated. To assess the mutagenic potential of [Cu(EDTA)] -2 , we analyzed the frequency of micronuclei in peripheral blood of mice and fish subjected to free and nanoencapsulated [Cu(EDTA)] -2 . The carcass of the fish was assessed by mass spectrometry to measure tissue copper. In mice, the frequency of micronuclei in animals exposed to free [Cu(EDTA)] -2 was significantly higher in the animals submitted to the nanoencapsulated form. In fish, only the free [Cu(EDTA)] -2 was able to induce increased frequency of micronuclei. Mass spectrometric analysis showed copper accumulation in the fish's liver studied, with significant difference in the control. In the gills of fish were not observed differences in copper concentration between the groups and the copper content was significantly lower than that found in the liver. The results suggest that free [Cu(EDTA)] -2 can induce mutagenic effects in mammals, but the nanoencapsulated seems to give more security to the product due ...

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“…aegypti [ 5 , 6 , 7 , 8 ]. Consequently, alternative insecticides obtained from plants, toxins from microorganisms, and new synthetic compounds have been researched, which ideally must present high efficiency, specificity, human safety, and lower environmental impact [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Eosin-Methylene Blue as a Photosensitizer for Larval Control of Aedes aegypti by a Photodynamic Process

Lima

Silva

Caires³

et al. 2018

Insects

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Aedes aegypti (Ae. aegypti) is a competent vector for transmitting important viral diseases such as yellow fever, dengue, chikungunya, and Zika. Several strategies have been applied to avoid Ae. aegypti proliferation by using environmental management, biological, and chemical approaches. However, the development of new methods for effective control of the insect vector population is still needed. Photodynamic control is an alternative way to control the vector population by using a physical approach based on the larval phototoxicity of a photosensitizer. In this context, the present study evaluated the use of eosin-methylene blue (EMB) as a new photosensitizer for photodynamic control of Ae. aegypti larval populations. The photodynamic assays were performed submitting Ae. aegypti third-instar larvae to different EMB concentrations (0.0, 0.5, 1.0, 5.0, 10.0, 50.0, and 100.0 µg mL−1) in combination of three different light doses (24.3, 48.6, and 97.2 J cm−2) under either white-light radiation from RGB LEDs or sunlight. The results demonstrated that EMB presented a rapid internalization into the larvae and was phototoxic. The photodynamic action induced 100% of larval mortality after about 40 min of sunlight irradiation even using low EMB concentration (0.5 µg mL−1). The findings reveal EMB as an effective photoactive compound to control larval populations of Ae. aegypti by photodynamic process induced by either sunlight or white-light from RGB LEDs.

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Evaluation of toxic effects with transition metal ions, EDTA, SBTI and acrylic polymers on Aedes aegypti (L., 1762) (Diptera: Culicidae) and Artemia salina (artemidae)

Cited by 17 publications

References 15 publications

Synthesis and characterization of (E)-4-((anthracen-9-ylmethylene) amino)-N- (pyridin-2-yl) benzenesulfonamide and its metal complexes: Evaluation of potential against the colon cancer cell line COLO-205 and biological activity profiles

Synthesis and characterization of (E)-4-((anthracen-9-ylmethylene) amino)-N- (pyridin-2-yl) benzenesulfonamide and its metal complexes: Evaluation of potential against the colon cancer cell line COLO-205 and biological activity profiles

Efeito Mutagênico do Edetato de Cobre ([Cu(EDTA)]-2) Livre e Nanoencapsulado em Camundongos e Peixes

Evaluation of Eosin-Methylene Blue as a Photosensitizer for Larval Control of Aedes aegypti by a Photodynamic Process

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