Evaluation of total antioxidant capacity of saliva in type 2 diabetic patients with and without periodontal disease: A case-control study

Pendyala, Gowri; Thomas, Biju; Joshi, Saurabh R

doi:10.4103/1947-2714.106208

Cited by 45 publications

(36 citation statements)

References 36 publications

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“…Therefore, the co-existence of both conditions could pathologically increase the effect of oxidative stress. [3839] In DN, excessive free radical generation has been shown to decrease the activities of antioxidant enzymes. The decrease in the GSH and GPx level was correlated with GR activity in DN.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant enzymes and lipid peroxidation in type 2 diabetes mellitus patients with and without nephropathy

et al. 2013

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Background:Oxidative stress has been considered to be a pathogenic factor of diabetic complications including nephropathy. There are many controversies and limited studies regarding the antioxidant enzymes in diabetic nephropathy.Aim:This study was to evaluate the levels of antioxidant enzymes and lipid peroxidation in Type-2 Diabetes Mellitus (DM) patients with and without nephropathy.Materials and Methods:The study included 90 age and sex matched subjects. Blood samples of all subjects were analyzed for all biochemical and oxidative stress parameters.Results:The malondialdehyde (MDA) levels and catalase (CAT) activity were significantly increased and reduced glutathione (GSH) levels and activities of glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly decreased in Type-2 DM with and without nephropathy as compared to controls and also in Type-2 DM with nephropathy as compared to Type-2 DM without nephropathy. There were an excellent positive correlation of glycohemoglobin (HbA1c) with MDA and a good negative correlation of GPx with GSH in controls. There were positive correlations of GR, CAT, and superoxide dismutase (SOD) with MDA in Type-2 diabetes patients with nephropathy.Conclusions:Intensity of oxidative stress in Type-2 diabetic patients with nephropathy is greater when compared with Type-2 diabetic patients without nephropathy as compared to the controls.

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Section: Discussionmentioning

confidence: 99%

Antioxidant enzymes and lipid peroxidation in type 2 diabetes mellitus patients with and without nephropathy

et al. 2013

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“…found that the total antioxidant capacity is inversely proportional to the severity of inflammation and can be used as an useful marker of periodontitis in health and diabetic patients. [4] However, it is also conceivable that HA administration to periodontal wound sites could achieve beneficial effects in periodontal tissue regeneration and periodontal disease treatment. [5]…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid: A boon in periodontal therapy

Dahiya¹,

2013

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Hyaluronic acid is a naturally occurring linear polysaccharide of the extracellular matrix of connective tissue, synovial fluid, and other tissues. Its use in the treatment of the inflammatory process is established in medical areas such as orthopedics, dermatology, and ophthalmology. The Pubmed/Medline database was searched for keywords “Hyaluronic acid and periodontal disease” and “Hyaluronic acid and gingivitis” which resulted in 89 and 22 articles respectively. Only highly relevant articles from electronic and manual search in English literature were selected for the present review article. In the field of dentistry, hyaluronic acid has shown anti-inflammatory and anti-bacterial effects in the treatment of periodontal diseases. Due to its tissue healing properties, it could be used as an adjunct to mechanical therapy in the treatment of periodontitis. Further studies are required to determine the clinical efficacy of hyaluronic acid in healing of periodontal lesion. The aim of the present review, article is to discuss the role of hyaluronic acid in periodontal therapy.

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“…For instance, glucose-containing carbonated soft drinks increase carbonyl stress burden (3) , which, in turn, may result in a decrease in antioxidant concentration in oral saliva (4) and enhance oxidative nitration in association with the inflammatory reaction (5) . From the biological viewpoint, the inflammatory reaction caused by such oxidative stress is highly associated with systemic diseases, such as metabolic syndrome, diabetes, hypertension, asthma and periodontal disease (PD) (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) . Oxidative stress (2,3,6,8,9,(13)(14)(15) pertaining to PD may be mediated through advanced glycation end-products that are created through non-enzymatic pathways from monosaccharide substances, dicarbonyls originating from the Maillard reaction, sugar self-oxidation and other molecular pathways (16,17) .…”

mentioning

confidence: 99%

A population-based study on the association between the intake of soft drinks and periodontal disease in Taiwanese adults aged 35–44 years (KCIS no. 33)

Fann¹,

Lai²,

Chiu³

et al. 2015

Public Health Nutr.

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Objective: To elucidate the association between the intake of soft drinks and periodontal disease (PD) among Taiwanese middle-aged adults. Design: The cross-sectional design was employed to assess a dose-response relationship between the intake of soft drinks and PD after controlling for relevant confounding factors, with adjusted odds ratios obtained from a multivariate logistic regression model. Setting: Keelung Community-based Integrated Screening (KCIS) programme, Keelung, Taiwan. Subjects: Participants (n 10 213) aged 35-44 years who had undergone oral checks for PD between 2005 and 2009. Results: A dose-response relationship between the intake of soft drinks and elevated risk for PD defined by community periodontal index ≥3 (the current status of PD) was noted (P = 0·02 by trend test). Compared with infrequent intake of soft drinks (≤2 times/week), the adjusted OR increased from 1·05 (95 % CI 0·92, 1·20) for the frequency of 3-4 times/week to 1·17 (95 % CI 1·03, 1·34) for the frequency of ≥5 times/week. A similar trend (P < 0·01) was also observed for PD defined by loss of attachment ≥1 (representing the long-term cumulative gum damage due to PD). Conclusions: A dose-response relationship between the intake frequency of soft drinks and PD was observed in Taiwanese middle-aged adults. Such evidence could be used in health promotion to support reductions in soft drink intake.

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Evaluation of total antioxidant capacity of saliva in type 2 diabetic patients with and without periodontal disease: A case-control study

Cited by 45 publications

References 36 publications

Antioxidant enzymes and lipid peroxidation in type 2 diabetes mellitus patients with and without nephropathy

Antioxidant enzymes and lipid peroxidation in type 2 diabetes mellitus patients with and without nephropathy

Hyaluronic acid: A boon in periodontal therapy

A population-based study on the association between the intake of soft drinks and periodontal disease in Taiwanese adults aged 35–44 years (KCIS no. 33)

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