Evaluation of topical human platelet lysate versus topical clobetasol in management of methotrexate-induced oral ulceration in rheumatoid arthritis patients: Randomized-controlled clinical trial

Ahmed, Eman Magdy; Ali, Shereen; Gaafar, Soheir; Rashed, Laila; Fayed, Hala Lotfy

doi:10.1016/j.intimp.2019.05.028

Cited by 5 publications

(6 citation statements)

References 19 publications

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“…After careful reviewing of the published literature on management of oral lesions of blistering skin diseases we believe that the use corticosteroid may offer healing by modulating the host immunity which has proven to be slower and less effective in comparison to growth factors 9,26 . Le et al in 2019 demonstrated the use of topical steroids in PV in a paediatric case with oral ulcer and healing was achieved after 5 weeks of treatment application 26 …”

Section: Discussionmentioning

confidence: 99%

“…Sample size was calculated using Epiinfo software for calculation of sample size to have study power 80% and confidence limit 0.05. Estimated effect size mean difference pain reduction 5.1 according to Ahmed et al 9 …”

Section: Methodsmentioning

confidence: 99%

“…Based on the emerging concepts of tissue regeneration and the use of growth factors to induce tissue repair, these complains could be targeted by a rapid‐acting repair mechanism. The use of growth factors as a modern line of treatment may gave promising results in different types of soft tissue wounds as well as mucositis and oral ulcers 9 . Platelet concentrates with their large content of growth factors may offer an effective treatment option that could be added to accelerate healing of oral tissues and promote a better quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Platelet‐rich fibrin a new approach in management of persistent oral ulcers in blistering skin diseases

Magdy

Shafik

Saadany

2022

Wound Repair Regeneration

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The present study designed to evaluate the healing power of platelet-rich fibrin (PRF) in terms of pain control and mucosal repair. A randomised, controlled, pilot clinical trial was conducted on 16 patients randomly distributed with 1:1 allocation ratio into two groups. The treatment group received PRF minced and mixed with orabase and the control group received clobetasol propionate 0.05% mixed with orabase. Pain reduction was evaluated as primary outcome along with mucositis healing as secondary outcome. A statistically significant difference in pain reduction was observed between the two groups (p ≤ 0.05). The clinical results at Day 7 has shown that PRF group had 100% pain reduction while, CP group had 32.5% reduction from base line.PRF offered superior clinical results providing rapid pain alleviation and accelerated ulcer healing compared to corticosteroids. K E Y W O R D S benign mucous membrane pemphigoid, clobetasol propionate, oral ulcers, pemphigus vulgaris, platelet-rich fibrin, Stevens-Johnson syndrome 1 | INTRODUCTION Long standing oral ulcers that fail to respond to classical steroid therapy is a clinical problem that needs applicable intervention. A good example of the long standing ulcers is represented by blistering skin diseases. These are immune mediated diseases associated with oral mucositis and ulceration. Despite being immune mediated, each has

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Platelet‐rich fibrin a new approach in management of persistent oral ulcers in blistering skin diseases

Magdy

Shafik

Saadany

2022

Wound Repair Regeneration

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“…As opções de tratamento de úlceras orais induzidas por uso de metotrexato podem abranger diversas medidas 10 . A suplementação com ácido fólico proporciona melhora a tolerância gastrointestinal e evita a toxicidade hematológica 5 .…”

Section: Discussionunclassified

Úlceras Orais Provocadas Por Metotrexato: Relato De Caso / Oral Ulcers Caused by Methotrexate: Case Report

Rocha¹,

Rodrigues²,

Rocha

et al. 2020

BJD

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“…The paste basically consists of finely ground pectin, fine gelatin and sodium CMC is dispersed in the combination of mineral oil and polyethylene gel base. This combination of mineral oil and polyethylene gel help to maintain the paste at its application site for about 15-150 min [68]. Usually the neutral poly-methacrylic acid and methyl ester were also used in the Orabase in order to avoid the irritation which is caused by the conventional ointments.…”

Section: Semi-solid Dosage Forms (Gels Pastes Ointments)mentioning

confidence: 99%

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

et al. 2019

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Mucoadhesive dosage forms may be intended for facilitation of prolonged retention time at the application site hence providing drug release in a controlled rate for enhanced improvement of therapeutic activity and its outcome. The buccal mucosa has been investigated for systemic drug delivery and local drug treatment or therapy that is subjected to first pass metabolism. The applicability of bio-adhesion approach in buccal drug delivery proved great therapeutic potential to overcome the limitation of conventional buccal drug delivery. The delivery via buccal route using mucoadhesive biopolymers such as various natural gums e.g. carrageenans, gum karaya, gum arabic, locust bean gum, khaya gum, gum ghatti, albizia gum, guar gum, starch, cellulose, larch gum and pectin etc. and various thiolated and carboxymethylated polymers has been the subject of interest since the early 20th century. The present article is focused mainly on the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, the manuscript then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium followed by the factors affecting mucoadhesion. Further the author has also discussed on the new generation of mucoadhesive polymers and their properties, recent mucoadhesive formulations for enhanced buccal drug delivery, various marketed products and patent literature. Various online search engines and scientific journals were employed for the collection of literature and scientific data and information related to the topic using keywords like mucoadhesive polymers, buccal drug delivery, buccal patches, tablets, films, gels, powder from the year 2002 and above.

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Evaluation of topical human platelet lysate versus topical clobetasol in management of methotrexate-induced oral ulceration in rheumatoid arthritis patients: Randomized-controlled clinical trial

Cited by 5 publications

References 19 publications

Platelet‐rich fibrin a new approach in management of persistent oral ulcers in blistering skin diseases

Platelet‐rich fibrin a new approach in management of persistent oral ulcers in blistering skin diseases

Úlceras Orais Provocadas Por Metotrexato: Relato De Caso / Oral Ulcers Caused by Methotrexate: Case Report

Overview of Mucoadhesive Biopolymers for Buccal Drug Delivery Systems

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