Evaluation of tolerance after continuous and prolonged oral administration of salbutamol to asthmatic patients.

Bhatia, SP; Davies, H J

doi:10.1111/j.1365-2125.1975.tb00557.x

Cited by 36 publications

(4 citation statements)

References 8 publications

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“…The possible role of tachyphylaxis during long-term oral treatment needs, however, to be con-sidered. Evidence for [27,28] and against [29][30][31][32] ta chyphylaxis after long-term prophylactic therapy has been found. Tachyphylaxis to oral salbutamol has not been proven adequately since no studies exist in which serum levels of the agent have been correlated with lung function and challenge studies.…”

Section: Discussionmentioning

confidence: 99%

Inhaled and Oral Salbutamol: How Effective in the Prophylaxis of Asthma?

Roux

Kotze²,

Wium³

et al. 1991

Respiration

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Inhaled and oral salbutamol were compared in 12 asthmatic patients for prophylaxis in antigen-induced asthma. The patients were pretreated with 0.2- and 1.0-mg doses of inhaled salbutamol and with the standard oral 4- and 8-mg slow-release (SR) salbutamol preparations. Bronchodilatation was monitored over the ensuing 3 h and protection against antigen challenge at the end of the period. On each study day the degree of baseline airway hyperreactivity was determined by histamine challenge. Precautions were taken during the antigen challenge to ensure a reproducible response. Blood levels of salbutamol were monitored at hourly intervals for the 3 h after treatment and during the asthmatic reaction subsequent to challenge. Both the 0.2- and 1.0-mg inhalations caused immediate bronchodilatation as compared to a placebo (p < 0.05), but only the 1.0-mg dose protected subjects against antigen challenge (p < 0.05). In comparison to the placebo, no bronchodilatation was achieved with the standard 4-mg oral preparation in spite of measurable blood levels, nor were the patients protected against antigen challenge at 3 h after pretreatment. However, the 8-mg SR salbutamol caused significant bronchodilatation within 2 h and suppressed antigen challenge responses as compared to placebo (p < 0.05). It can be concluded that doses of inhaled salbutamol higher than the conventional 0.2- or the standard 4-mg oral preparations are required to protect asthmatics against inadvertent antigen exposure. In patients who are unable to use inhalers effectively, the SR preparation can be considered as an alternative

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Section: Discussionmentioning

confidence: 99%

Inhaled and Oral Salbutamol: How Effective in the Prophylaxis of Asthma?

Roux

Kotze²,

Wium³

et al. 1991

Respiration

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“…The last findings have not been replicated by all investigators (Bhatia & Davies 1975;Formgren 1976;Svedmyr, Larsson & Thiringen 1976), however, and their relation to beta receptor density and cAMP response magnitude has not yet been determined. The effect of chronic antidepressant treatment on either the output of the above organs and tissues or on their beta receptor density has not been studied sufficiently to allow a general conclusion as to the functional or receptor effects of these drugs in the periphery (Frazer, Hess, Mendels, Gable, Kunkel & Bender 1978;Wolfe et al 1978).…”

Section: The Subsensitivity Hypothesismentioning

confidence: 92%

Epinephrine, the neglected catecholamine

Roth

1983

Behav Brain Sci

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“…Oral salbutamol has a slower rate of onset -it has to be absorbed by the gut, but has a more prolonged action when compared to inhaled salbutamol 7 . However the side effects from oral salbutamol are often more pronounced (palpitations and tremor) and the slow onset of action limits its use in acute settings 8 . Inhaled salbutamol has a direct effect on the smooth muscle of the bronchi, with only a small proportion absorbed into the systemic circulation.…”

Section: Management Of Asthma In Malawi Bronchodilationmentioning

confidence: 99%

Teaching Corner: Adult Asthma in Malawi

Coleman¹

2011

Mal. Med. J

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Asthma affects millions of people worldwide. It is often considered to be benign and is therefore under-diagnosed and under-treated. In fact asthma can be a very serious condition with significant morbidity and mortality. Most of the deaths are in patients over the age of 45 and many deaths could have been prevented with prompt medical treatment and good long term care 1. The exact incidence of asthma in Malawi is unknown but it is a common clinical diagnosis. Recognising and treating asthma appropriately will save lives. Definition Diagnosis of asthma is clinical. It requires a history of variable airways obstruction, with more than one of the following symptoms: wheeze, cough, chest tightness and breathlessness 2. The symptoms are usually episodic, so between 'asthma attacks' a patient may be completely well and have normal respiratory function.

show abstract

Evaluation of tolerance after continuous and prolonged oral administration of salbutamol to asthmatic patients.

Cited by 36 publications

References 8 publications

Inhaled and Oral Salbutamol: How Effective in the Prophylaxis of Asthma?

Inhaled and Oral Salbutamol: How Effective in the Prophylaxis of Asthma?

Epinephrine, the neglected catecholamine

Teaching Corner: Adult Asthma in Malawi

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