Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria

Udiong, C. E. J.; Udoh, A. E.; Etukudoh, M. E.

doi:10.1007/bf02913318

Cited by 77 publications

(90 citation statements)

References 7 publications

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“…6 of the control subjects had abnormal thyroid status (Table 5). These findings show a high incidence of abnormal thyroid hormone levels in diabetic population which is supported by the various studies (Table 6) [9][10][11][12][13]. In a study by Moghetti et al [14], 89 % of patients had hypothyroidism and 11 % had hyperthyroidism.…”

Section: Discussionsupporting

confidence: 56%

“…Celani et al [9] showed maximum prevalence of subclinical hypothyroidism followed by hypothyroidism (23.1 %). Hypothyroidism was shown to be more prevalent thyroid disorder in type 2 diabetics in the studies of Udiong et al [13]. The presence of both raised and low levels of thyroid hormones levels in diabetics may be due to modified TRH synthesis and release [15].…”

Section: Discussionmentioning

confidence: 99%

“…Low serum T3 is due to reduced peripheral conversion of T4 to T3 via 5 0 monodeiodination reaction [17]. It is known that insulin, an anabolic hormone enhances the levels of FT4 while it suppresses the levels of T3 by inhibiting hepatic conversion of T4-T3 [13]. TRH synthesis decreases in diabetes mellitus and also there is loss of nocturnal TSH peak which is responsible for the occurrences of low thyroid hormone levels in some diabetics.…”

Section: Discussionmentioning

confidence: 99%

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Thyroid Disorders in Patients of Type 2 Diabetes Mellitus

et al. 2013

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The study was planned to assess the prevalence of thyroid disorders in type 2 diabetes in North Indian population and to correlate the serum insulin and glycosylated haemoglobin levels with thyroid hormones. It is a case control study. One hundred and twenty patients of type 2 diabetes were included in the study along with 117 adults of the same age group and normal glucose levels as controls. All blood samples were taken from subjects who fasted for at least 12 h before the blood collection. Glycosylated hemoglobin was determined by ion exchange chromatography and serum insulin and thyroid hormones were assessed through enzyme linked immunosorbent assay. Fasting blood glucose and glycosylated haemoglobin levels were significantly higher in diabetics showing a poor glucose control. Serum tri-iodothyronine values were significantly lower in diabetics. There was a significant correlation between glycosylated haemoglobin and thyroid hormones. There was no correlation between serum insulin and thyroid hormones.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Thyroid Disorders in Patients of Type 2 Diabetes Mellitus

et al. 2013

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“…This outcome is in line with other studies which found that the overall prevalence of TD among diabetic subjects was 12.3% [14], 12.7% [15], 12.5% [16], and 13.4%) [17]. Moreover, a study found that 46.5% of patients with DM had abnormal thyroid profile [18]. Furthermore, a study carried out in Kingdom of Saudi Arabia on patients with T2DM found that 16% of them had TD [19].…”

Section: Discussion:-supporting

confidence: 89%

Do Gamma Rays of Cancer Radiotherapy Effect on the Sequence of Collagenase Gene?

Mousa¹,

Ali²,

Elhadary³

et al. 2016

IJAR

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“…The results obtained revealed that alloxan induced the reduction in the level of T 3 and T 4 hormones and that due to the effect of diabetes, which can enhance the reduction of thyroid stimulating hormone (TSH) leading to alterations in thyroid hormone system. Therefore, T 3 and T 4 production and iodide uptake by the thyroid are diminished as well as T 4 deiodination to T 3 in peripheral tissues is decreased (Calvo et al, 1997 andUdiong et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycaemic Effect of γ-Irradiated Clove Extract on Alloxan-Induced Diabetic Rats

2011

Egypt. J. Rad.Sci.

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IABETES is characterized by hyperglycaemia and elevated production of reactive oxygen species (ROS). Clove is full of natural antioxidants such as polyphenols and essential oils. The aim of the study was to investigate the hypoglycaemic effect of clove extract in diabetic rats.The results with test rats indicated that alloxan administration induced the elevation of glucose level, activity of some liver enzymes, malondialdehyde (MDA), urea and creatinine concentrations as well as the level of some lipid contents.While the level of insulin, total thyroid hormones triiodothyronin (T 3 ) and thyroxine (T 4 ), glutathione content (GSH) in addition to the concentration of high density lipoprotein (HDL-C) were decreased under the effect of alloxan.As a result of treatment of diabetic rats with raw or irradiated clove extract, hyperglycaemia, hepatic, renal and endocrine abnormalities induced by alloxan were improved.Conclusion: clove extract exerts a dietary antidiabetic benefit and affect a partial normalization of the biochemical changes associated with alloxan-induced diabetes mellitus in rats. Furthermore, the study indicated that treatment of cloves with 10 kGy of gamma irradiation had no significant effect on the antidiabetic properties of the extract made from such cloves. This confirms the suitability of irradiation for the improvement of the hygienic quality of cloves.

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Evaluation of thyroid function in diabetes mellitus in Calabar, Nigeria

Abstract: ABSTRACT

Cited by 77 publications

References 7 publications

Thyroid Disorders in Patients of Type 2 Diabetes Mellitus

Thyroid Disorders in Patients of Type 2 Diabetes Mellitus

Do Gamma Rays of Cancer Radiotherapy Effect on the Sequence of Collagenase Gene?

Hypoglycaemic Effect of γ-Irradiated Clove Extract on Alloxan-Induced Diabetic Rats

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