The study was planned to assess the prevalence of thyroid disorders in type 2 diabetes in North Indian population and to correlate the serum insulin and glycosylated haemoglobin levels with thyroid hormones. It is a case control study. One hundred and twenty patients of type 2 diabetes were included in the study along with 117 adults of the same age group and normal glucose levels as controls. All blood samples were taken from subjects who fasted for at least 12 h before the blood collection. Glycosylated hemoglobin was determined by ion exchange chromatography and serum insulin and thyroid hormones were assessed through enzyme linked immunosorbent assay. Fasting blood glucose and glycosylated haemoglobin levels were significantly higher in diabetics showing a poor glucose control. Serum tri-iodothyronine values were significantly lower in diabetics. There was a significant correlation between glycosylated haemoglobin and thyroid hormones. There was no correlation between serum insulin and thyroid hormones.
Introduction: Miscarriage is the spontaneous loss of the conceptus before 20 weeks of gestation. Several disorders are known to contribute to recurrent miscarriage including: chromosomal anomalies; anti-cardiolipin antibodies; endocrine disorders such as poorly controlled diabetes mellitus; hyperprolactinaemia and thyroid diseases; and pelvic anatomic abnormalities. Study aimed to investigate the endocrine dysfunction in recurrent pregnancy loss Material and Methods: A prospective study comprising 70 subjects was carried out. Fifty cases of recurrent abortions constituted the study group. Twenty healthy multipara females of same reproductive age group constituted the control group. Venous blood samples were collected, and serum was analyzed for hormone analysis (T 3 , T 4 , TSH, LH, FSH, PRL, Testosterone) by ELISA method. Results: The mean prolactin level in cases of recurrent abortions was 19.96 ng/ml, while in controls was 11.77 ng/ ml. The p value was 0.006 which was found to be statistically highly significant. The mean TSH level in recurrent abortions cases was 5.81 mIU/L, while in controls was 1.95 mIU/L. The p value was 0.004 which was found to be statistically highly significant. Conclusion: The patients with recurrent abortions had significantly raised levels of TSH and Prolactin. The prevalence of thyroid disorder and hyperprolactinemia were higher in pregnant women with a history of recurrent abortion compared with healthy pregnant control population. Universal screening of pregnant females for endocrine profile can improve the foetal outcome as well as social well-being of females.
Objectives: To evaluate and compare Renal, Hepatic and Coagulation profiles in normotensive pregnant females at 20 weeks or more gestation and in cases of Pregnancy induced Hypertension at same gestation. Methods:The study was conducted on 100 pregnant females divided into two groups of 50 each: cases of PIH (Study group) and normotensive pregnant females (Control group) and all these females were at 20 weeks or more gestation. Blood sample was collected at the period of gestation when they attended Gynaecology OPD at Rajindra Hospital, Patiala. Blood Urea, S. Creatinine, S. Uric Acid, S. Transaminases and Platelet count were evaluated and compared. Results:The mean Blood Urea was 25.92±6.16 mg% (study group) compared to 24.60±3.21 mg% (control group) (p=0.1823).The difference did not attain statistical significance. The mean S. creatinine was 1.05±0.19 mg% (study group) compared to 0.71±0.20 mg% (control group) (p<0.0001) while the mean S. uric acid was 5.43±1.25 mg% (study group) compared to 3.86±0.72 mg% (control group) (p<0.0001) and the difference was statistically highly significant. The mean AST levels were 57.42±58.26 IU/L(study group) compared to 25.02±6.32 IU/L(control group) (p=0.0002) while the mean ALT levels were 51.80±53.98 IU/L(study group) compared to 24.04±8.56 IU/L(control group)(p=0.0005). The mean platelet count was 223700.00 ± 70239.02 mm 3 (study group) compared to 314860.00±33815.83 mm 3 (control group) (p<0.0001). The difference was statistically highly significant. Conclusion:Patients with PIH have altered renal, hepatic and coagulation profiles thereby deranging the function of different organs. Timely assessment of various blood parameters in such patients will help in preventing occurrence of PIH and in planning proper intervention to improve both maternal and fetal outcome in established pre-eclamptic women.
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