Evaluation of the Webler-Brown model for estimating tetrachloroethylene exposure from vinyl-lined asbestos-cement pipes

Spence, Lisa; Aschengrau, Ann; Gallagher, Lisa G.; Webster, Thomas F.; Heeren, Timothy; Ozonoff, David

doi:10.1186/1476-069x-7-24

Cited by 23 publications

(17 citation statements)

References 19 publications

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“…On the other hand, results from two validation studies indicate good correlation between PCE concentrations in historical water samples and exposure estimates based on the original Webler-Brown flow algorithm (Spearman correlation coefficient=0.48, p<0.0001) (Spence et al 2008), as well as exposure estimates based on the EPANET water distribution system modeling software (Spearman correlation coefficient=0.65, P<0.001) (Gallagher et al unpublished manuscript). While these validation study results suggest the magnitude of exposure misclassification is relatively small, particularly given the quartile exposure categories used in the current analysis, it likely hampered our ability to detect a modest increase in the risk of pregnancy loss.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Pregnancy Loss

et al. 2009

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There is little information on the impact of solvent-contaminated drinking water on pregnancy outcomes. This retrospective cohort study examined whether maternal exposure to tetrachloroethylene (PCE) - contaminated drinking water in the Cape Cod region of Massachusetts influenced the risk of clinically recognized pregnancy loss. The study identified exposed (n=959) and unexposed (1,087) women who completed a questionnaire on their residential and pregnancy histories, and confounding variables. Exposure was estimated using water distribution system modeling software. No meaningful associations were seen between PCE exposure level and the risk of clinically recognized pregnancy loss at the exposure levels experienced by the study population. Because PCE remains a common water contaminant, it is important to continue monitoring its impact on women and their pregnancies.

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Section: Discussionmentioning

confidence: 99%

Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Pregnancy Loss

et al. 2009

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“…Generalized estimating equation (GEE) analyses were conducted to account for non-independent outcomes arising from several children born to the same woman [23,24]. Eighty-eight percent of the mothers had two or more children during the study period.…”

Section: Methodsmentioning

confidence: 99%

Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of congenital anomalies: a retrospective cohort study

et al. 2009

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BackgroundPrior animal and human studies of prenatal exposure to solvents including tetrachloroethylene (PCE) have shown increases in the risk of certain congenital anomalies among exposed offspring.ObjectivesThis retrospective cohort study examined whether PCE contamination of public drinking water supplies in Massachusetts influenced the occurrence of congenital anomalies among children whose mothers were exposed around the time of conception.MethodsThe study included 1,658 children whose mothers were exposed to PCE-contaminated drinking water and a comparable group of 2,999 children of unexposed mothers. Mothers completed a self-administered questionnaire to gather information on all of their prior births, including the presence of anomalies, residential histories and confounding variables. PCE exposure was estimated using EPANET water distribution system modeling software that incorporated a fate and transport model.ResultsChildren whose mothers had high exposure levels around the time of conception had an increased risk of congenital anomalies. The adjusted odds ratio of all anomalies combined among children with prenatal exposure in the uppermost quartile was 1.5 (95% CI: 0.9, 2.5). No meaningful increases in the risk were seen for lower exposure levels. Increases were also observed in the risk of neural tube defects (OR: 3.5, 95% CI: 0.8, 14.0) and oral clefts (OR 3.2, 95% CI: 0.7, 15.0) among offspring with any prenatal exposure.ConclusionThe results of this study suggest that the risk of certain congenital anomalies is increased among the offspring of women who were exposed to PCE-contaminated drinking water around the time of conception. Because these results are limited by the small number of children with congenital anomalies that were based on maternal reports, a follow-up investigation should be conducted with a larger number of affected children who are identified by independent records.

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“…Furthermore, the exposure assessment predicted the annual mass of PCE delivered to each subject’s residence during gestation and early childhood. Despite the concern for exposure misclassification, validation studies indicate reasonable correlation between our exposure estimates and PCE concentrations in historical water samples [44]. Though unmeasured confounding is a concern, the current and previous studies from this cohort noted little or no confounding because of the irregular pattern of contamination [45].…”

Section: Discussionmentioning

confidence: 68%

Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study

Mahalingaiah

Winter

Aschengrau

2016

Reproductive Toxicology

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Background Tetrachloroethylene (PCE) is an organic lipophilic solvent with possible neuroendocrine toxicity. The objective of this study was to determine the association of prenatal and early childhood exposure to PCE-contaminated drinking water and development of adult-onset Polycystic Ovary Syndrome (PCOS), endometriosis, difficulty conceiving and miscarriage. Methods Five-hundred exposed and 331 unexposed female participants born between 1969 and 1983 completed questionnaires on demographic and lifestyle characteristics, and reproductive disorders. Residential locations from the prenatal period through five years of age were used to estimate early life PCE exposure with water modeling software. Results For any early life exposure to PCE, the adjusted risk ratio for PCOS was 0.9 (95% CI: 0.5–1.6). No statistically significant associations were observed for increasing levels of exposure with PCOS or the other reproductive disorders. Conclusion No meaningful associations were found among adult women with early life exposure to PCE-contaminated drinking water and adult-onset reproductive disorders.

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Evaluation of the Webler-Brown model for estimating tetrachloroethylene exposure from vinyl-lined asbestos-cement pipes

Cited by 23 publications

References 19 publications

Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Pregnancy Loss

Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Pregnancy Loss

Prenatal exposure to tetrachloroethylene-contaminated drinking water and the risk of congenital anomalies: a retrospective cohort study

Association of prenatal and early life exposure to tetrachloroethylene (PCE) with polycystic ovary syndrome and other reproductive disorders in the cape cod health study: A retrospective cohort study

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