“…Because this was a screening study, we did not examine exhaustively the effects of each variable but rather attempted to identify which variables were the most essential to control in order to achieve accurate and reproducible dissolution results. Previous research has focused on assembly variables such as dissolved gas, vessel centering, vibration, vessel tilt, paddle height, rotation speed, base plate levelness, shaft wobble, temperature, vessel shape, belt tension, and shaft verticality (3,(7)(8)(9)(10)(11)(12). Building on these earlier studies, we attempted a more systematic approach that included an assessment of combination effects from two or more concurrently perturbed variables.…”