Evaluation of the satiating properties of a fish protein hydrolysate among overweight women

Zaïr, Yassine; Duclos, Elisa; Housez, Béatrice; Vergara, Coralie; Cazaubiel, Murielle; Soisson, Florian

doi:10.1108/nfs-06-2013-0075

Cited by 11 publications

(16 citation statements)

References 28 publications

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“…Our results confirm the previous in vitro and in vivo ( 26 – 28 ) results of the efficacy of a FPH, Slimpro ® , obtained from blue whiting ( M. poutassou ) muscle by enzymatic hydrolysis in stimulating the secretion of CCK and GLP-1. Moreover, Slimpro was effective on body weight and particularly in controlling body composition.…”

Section: Discussionsupporting

confidence: 91%

“…The increase of CCK and GLP-1 was statistically significant when compared with placebo without any differences among the two tested doses. The results obtained in this study confirmed the preliminary results obtained in the earlier in vitro and in vivo studies carried out on blue whiting FPH Slimpro ( 26 – 28 ). As a consequence of FPH consumption, body composition was changed.…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies demonstrated the efficacy of a FPH obtained from from blue whiting ( Micromesistius poutassou ) muscle on STC-1 (secretin tumor cell) cell line ( 26 ), rats ( 27 ), and humans ( 28 ) in stimulating the release of CCK and GLP-1. Based on these preliminary data, we conducted a clinical study in humans to confirm the weight management efficacy of FPH.…”

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confidence: 99%

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Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion

Nobile¹,

Duclos

Michelotti³

et al. 2016

Food & Nutrition Research

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BackgroundFish protein hydrolysates (FPHs) have been reported as a suitable source of proteins for human nutrition because of their balanced amino acid composition and positive effect on gastrointestinal absorption.ObjectiveHere, we investigated the effect of a FPH, Slimpro®, obtained from blue whiting (Micromesistius poutassou) muscle by enzymatic hydrolysis, on body composition and on stimulating cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1) secretion.DesignA randomized clinical study was carried out on 120, slightly overweight (25 kg/m2 ≤ BMI<30 kg/m2), male (25%) and female (75%) subjects. FPH was tested in a food supplement at two doses (1.4 and 2.8 g) to establish if a dose–effect relationship exists. Product use was associated with a mild hypocaloric diet (−300 kcal/day). Body composition (body weight; fat mass; extracellular water; and circumference of waist, thighs, and hips) and CCK/GLP-1 blood levels were measured at the beginning of the study and after 45 and 90 days of product use. CCK/GLP-1 levels were measured since they are involved in controlling food intake.ResultsTreated subjects reported an improvement of body weight composition and an increased blood concentration of both CCK and GLP-1. No differences were found between the 1.4 and 2.8 g FPH doses, indicating a plateau effect starting from 1.4 g FPH.ConclusionsBoth 1.4 and 2.8 g of FPH were effective in improving body composition and in increasing CCK and GLP-1 blood levels.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

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confidence: 99%

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Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion

Nobile¹,

Duclos

Michelotti³

et al. 2016

Food & Nutrition Research

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“…However, since this was a study population with older adults who lived in a nursing home setting, the results are not directly transferable to our study population with homedwelling older adults. Based on a few previous studies investigating the effect of supplements containing protein hydrolysates from fish on metabolic health (17,26) , we hypothesised that small doses of CPH may be effective due to the content of small, easily absorbable bioactive peptides. These are capable of rapidly affecting different metabolic pathways involved in glucose regulation and hence leading to a more rapid glucose response in the body.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study

et al. 2019

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A large proportion of older adults are affected by impaired glucose metabolism. Previous studies with fish protein have reported improved glucose regulation in healthy adults, but the evidence in older adults is limited. Therefore, we wanted to assess the effect of increasing doses of a cod protein hydrolysate (CPH) on postprandial glucose metabolism in older adults. The study was a double-blind cross-over trial. Participants received four different doses (10, 20, 30 or 40 mg/kg body weight (BW)) of CPH daily for 1 week with 1-week washout periods in between. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose and insulin in 20 min intervals for 120 min. The secondary outcome was postprandial response in plasma glucagon-like peptide 1 (GLP-1). Thirty-one subjects aged 60–78 years were included in the study. In a mixed-model statistical analysis, no differences in estimated maximum value of glucose, insulin or GLP-1 were observed when comparing the lowest dose of CPH (10 mg/kg BW) with the higher doses (20, 30 or 40 mg/kg BW). The estimated maximum value of glucose was on average 0·28 mmol/l lower when the participants were given 40 mg/kg BW CPH compared with 10 mg/kg BW (P = 0·13). The estimated maximum value of insulin was on average 5·14 mIU/l lower with 40 mg/kg BW of CPH compared with 10 mg/kg BW (P = 0·20). Our findings suggest that serum glucose and insulin levels tend to decrease with increasing amounts of CPH. Due to preliminary findings, the results require further investigation.

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“…Four studies were found that investigated the impact of FPH on subjective appetite ratings and/or circulating appetite hormones in healthy adults [69,70,76,79]. The earliest investigation by Zaïr et al [79] found no significant differences between a blue whiting-derived FPH and PLA on area under the curve (AUC) subjective hunger perceptions or biomarkers of appetite/satiety including plasma cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1). Similarly, no difference in ad libitum energy intake was found between conditions.…”

Section: Appetite Regulationmentioning

confidence: 99%

The Potential Role of Fish-Derived Protein Hydrolysates on Metabolic Health, Skeletal Muscle Mass and Function in Ageing

Lees

Carson

2020

Nutrients

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Fish protein represents one of the most widely consumed dietary protein sources by humans. The processing of material from the fishing industry generates substantial unexploited waste products, many of which possess high biological value. Protein hydrolysates, such as fish protein hydrolysates (FPH), containing predominantly di- and tripeptides, are more readily absorbed than free amino acids and intact protein. Furthermore, in animal models, FPH have been shown to possess numerous beneficial properties for cardiovascular, neurological, intestinal, renal, and immune health. Ageing is associated with the loss of skeletal muscle mass and function, as well as increased oxidative stress, compromised vascularisation, neurological derangements, and immunosenescence. Thus, there appears to be a potential application for FPH in older persons as a high-quality protein source that may also confer additional health benefits. Despite this, there remains a dearth of information concerning the impact of FPH on health outcomes in humans. The limited evidence from human interventional trials suggests that FPH may hold promise for supporting optimal body composition and maintaining gut integrity. FPH also provide a high-quality source of dietary protein without negatively impacting on subjective appetite perceptions or regulatory hormones. Further studies are needed to assess the impact and utility of FPH on skeletal muscle health in older persons, ideally comparing FPH to ‘established’ protein sources or a non-bioactive, nitrogen-matched control. In particular, the effects of acute and chronic FPH consumption on post-exercise aminoacidaemia, skeletal muscle protein synthesis, and intramyocellular anabolic signalling in older adults are worthy of investigation. FPH may represent beneficial and sustainable alternative sources of high-quality protein to support skeletal muscle health and anabolism in ageing, without compromising appetite and subsequent energy intake.

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Evaluation of the satiating properties of a fish protein hydrolysate among overweight women

Cited by 11 publications

References 28 publications

Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion

Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion

Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study

The Potential Role of Fish-Derived Protein Hydrolysates on Metabolic Health, Skeletal Muscle Mass and Function in Ageing

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