Supplementation with a fish protein hydrolysate (<i>Micromesistius poutassou</i>): effects on body weight, body composition, and CCK/GLP-1 secretion

Nobile, Vincenzo; Duclos, Elisa; Michelotti, Angela; Bizzaro, Gioia; Negro, Massimo; Soisson, Florian

doi:10.3402/fnr.v60.29857

Cited by 57 publications

(55 citation statements)

References 30 publications

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“…63 A study investigating the effect of 2 different doses of supplementation with a fish protein hydrolysate from blue whiting in 120 overweight individuals reported both doses to improve body composition and decrease body weight as well as increase levels of cholecystokinin and glucagon-like peptide 1 in serum. 18 The trial lasted for 90 days, and participants were allocated into 3 arms, receiving either 1.4 g or 2.8 g of fish protein hydrolysate per day or 1.4 g of whey protein isolate as placebo, in addition to receiving an individually adjusted mildly hypocaloric diet (À300 kcal/d). Both doses of fish protein hydrolysate were found to significantly reduce body weight, body mass index, and fat mass as well as waist, thigh, and hip circumference when compared with placebo.…”

Section: Intervention Studies With Fish Peptide Supplements In Humansmentioning

confidence: 99%

“…Preliminary data suggest that bioactive peptides derived from marine resources may have a beneficial effect on several health outcomes related to metabolic health. [17][18][19][20] This increased interest and early research have provided a platform from which to examine the potential for better utilization of rest material from the fishing industry. Waste material with a high content of high-quality protein may be valuable for human consumption, and fishderived protein hydrolysates with bioactive peptides are hypothesized to be particularly beneficial.…”

Section: Introductionmentioning

confidence: 99%

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Fish–derived proteins and their potential to improve human health

2019

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Emerging evidence from studies evaluating the effect of lean fish consumption in humans suggests that proteins from fish have several beneficial metabolic effects. Rest, or waste, material from the fishing industry contains high-quality proteins, and utilization of this material offers novel possibilities for the development of protein-containing products that might be beneficial for human consumption. Fish-derived peptides containing bioactive amino acid sequences suggested to beneficially influence pathways involved in body composition, hypertension, lipid profile, and regulation of glucose metabolism are of particular interest, although the results of published studies are conflicting. This review aims to summarize current knowledge from animal studies and clinical interventions in humans evaluating the effects of lean fish, fish proteins, and fish-derived peptides on outcomes related to metabolic health. Fish proteins have a high content of taurine, and animal trials suggest that taurine mediates some of the beneficial effects observed thus far, although the mechanisms by which fish peptides exert their action are not yet elucidated. At this time, the literature is inconsistent, and there is insufficient mechanistic evidence to support a beneficial effect of fish-derived peptides on metabolic health.

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Section: Intervention Studies With Fish Peptide Supplements In Humansmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fish–derived proteins and their potential to improve human health

2019

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“…Marine protein hydrolysates from fish exhibit several bioactive roles, such as anti-hypertension, anti-oxidant, immunomodulating, anti-appetizing, antimicrobial, anti-cholesterol and opioid antagonist (Imen et al 2015;Vincenzo et al 2016). In addition, administration of these short range peptides increases the plasma amino acid concentration and skeletal muscle protein anabolism thereby improving muscle hypertrophy and accelerating recovery of muscle cells making them suitable for sports nutrition (Manninen 2009).…”

Section: Introductionmentioning

confidence: 99%

Effects of sea horse (Hippocampus abdominalis)-derived protein hydrolysate on skeletal muscle development

Muthuramalingam

Kim

Jeon

et al. 2017

JABC

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Hippocampus abdominalis, the big belly sea horse, is widely known for its medicinal value in Chinese folk medicine. In this study, extract obtained by proteolytic degradation of this species was investigated for its effects on skeletal muscle development, both in vitro and in vivo. Muscle cell lines (C 2 C 12 and L 6 ) treated with the bioactive peptide did not have any detrimental effects on the cell viability, which was above 80%. Optical microscopy analysis on the morphology of the sea horse extract (SHE)-treated cells showed enhanced differentiating ability with myotube formation. Moreover, cells incubated with the hydrolysate displayed decreased proliferation rate, as recorded by the electric cell substrate impedance sensing system, thereby supporting enhanced differentiation. For a period of 12 weeks, mice models were fed with SHE and simultaneously subjected to treadmill exercise, which increased the expression of Myogenin, a key myogenic regulatory factor. In addition, there was an increase in the expression of AMPK-and Cytochrome C, both of which are important in mitochondrial biogenesis. Thus, the SHE from Hippocampus abdominalis can be a promising candidate as protein supplement aiding muscle development.

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“…However, since this was a study population with older adults who lived in a nursing home setting, the results are not directly transferable to our study population with homedwelling older adults. Based on a few previous studies investigating the effect of supplements containing protein hydrolysates from fish on metabolic health (17,26) , we hypothesised that small doses of CPH may be effective due to the content of small, easily absorbable bioactive peptides. These are capable of rapidly affecting different metabolic pathways involved in glucose regulation and hence leading to a more rapid glucose response in the body.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study

et al. 2019

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A large proportion of older adults are affected by impaired glucose metabolism. Previous studies with fish protein have reported improved glucose regulation in healthy adults, but the evidence in older adults is limited. Therefore, we wanted to assess the effect of increasing doses of a cod protein hydrolysate (CPH) on postprandial glucose metabolism in older adults. The study was a double-blind cross-over trial. Participants received four different doses (10, 20, 30 or 40 mg/kg body weight (BW)) of CPH daily for 1 week with 1-week washout periods in between. The primary outcome was postprandial response in glucose metabolism, measured by samples of serum glucose and insulin in 20 min intervals for 120 min. The secondary outcome was postprandial response in plasma glucagon-like peptide 1 (GLP-1). Thirty-one subjects aged 60–78 years were included in the study. In a mixed-model statistical analysis, no differences in estimated maximum value of glucose, insulin or GLP-1 were observed when comparing the lowest dose of CPH (10 mg/kg BW) with the higher doses (20, 30 or 40 mg/kg BW). The estimated maximum value of glucose was on average 0·28 mmol/l lower when the participants were given 40 mg/kg BW CPH compared with 10 mg/kg BW (P = 0·13). The estimated maximum value of insulin was on average 5·14 mIU/l lower with 40 mg/kg BW of CPH compared with 10 mg/kg BW (P = 0·20). Our findings suggest that serum glucose and insulin levels tend to decrease with increasing amounts of CPH. Due to preliminary findings, the results require further investigation.

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Supplementation with a fish protein hydrolysate (Micromesistius poutassou): effects on body weight, body composition, and CCK/GLP-1 secretion

Cited by 57 publications

References 30 publications

Fish–derived proteins and their potential to improve human health

Fish–derived proteins and their potential to improve human health

Effects of sea horse (Hippocampus abdominalis)-derived protein hydrolysate on skeletal muscle development

Supplementation with cod protein hydrolysate in older adults: a dose range cross-over study

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