Evaluation of the Safety and Toxicity of the Original Copper Nanocomposite Based on Poly-N-vinylimidazole

Abstract

A new original copper nanocomposite based on poly-N-vinylimidazole was synthesized and characterized by a complex of modern physicochemical and biological methods. The low cytotoxicity of the copper nanocomposite in relation to the cultured hepatocyte cells was found. The possibility to involve the copper from the nanocomposite in the functioning of the copper-dependent enzyme systems was evaluated during the incubation of the hepatocyte culture with this nanocomposite introduced to the nutrient medium. The synthesized new water-soluble copper-containing nanocomposite is promising for biotechnological and biomedical research as a new non-toxic hydrophilic preparation that is allowed to regulate the work of key enzymes involved in energy metabolism and antioxidant protection as well as potentially serving as an additional source of copper.

Water-Soluble Nanocomposites Containing Co3O4 Nanoparticles Incorporated in Poly-1-vinyl-1,2,4-triazole

“…Magnetic nanocomposite polymeric materials are interesting for study from the point of view of applied and fundamental science [9]. Polymer matrices used as stabilizers improve the properties of nanocomposites: they make it possible to obtain particles with a higher degree of uniformity and a narrow range of particle size distribution, which makes them possible to use in medicine [10][11][12][13].…”