Evaluation of the role of insulin-like growth factor-1 and some minerals in treatment of hypothyroid rats

Abstract

Untreated hypothyroidism can contribute to hypertension, dyslipidemia, infertility, cognitive impairment, and neuromuscular dysfunction. The management of hypothyroidism focuses on ensuring that patients receive appropriate thyroid hormone replacement therapy and monitoring their response. Hormone and supplement therapy should have beneficial effects. The present study was designed to evaluate IGF-1 and some supplements in thyroid-stimulating hormone (TSH) and thyroid hormones (T3 and T4) concentrations in response to treatment with T4, IGF-1, Zn, Se, and Vit.B12 in experimentally induced hypothyroid rats. Forth-week-old male Wistar albino rats (weight 180–250 g). Rats were given methimazole to induce hypothyroid and were randomly divided into seven groups including those treated with levothyroxine T4, IGF1, T4 + IGF1, T4 + Zinc, T4 +Selenium, T4 +B12, and T4+Zinc+ Selenium+ B12. The body weight was evaluated for each group before and after the treatment. The concentrations of TSH and thyroid hormones were measured using the ELISA technique. The data showed that the animal model of hypothyroidism had increased body weight in comparison to the control groups (P≤0.05). The body weight of rats in treatment groups with IGF-1 was significantly increased from (221 ± 16.8) g to (276.2 ± 25.9) g.