Evaluation of the role of ceruloplasmin as an acute-phase reactant

Rice, Eugene W.

doi:10.1016/0009-8981(61)90110-3

Cited by 35 publications

(16 citation statements)

References 8 publications

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“…Caeruloplasmin is one of the acute-phase-reacting proteins, the possible 'useful' role of which in the systemic inflammatory response has long remained speculative (Rice, 1961;Crockson et al, 1966;Frieden and Hsieh, 1976). It may prove to be related to its powerful antioxidant property.…”

Section: Discussionmentioning

confidence: 99%

Serum Antioxidant Activity in Normal and Abnormal Subjects

et al. 1979

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SUMMARY Serum antioxidant activity (ADA) was correlated with the serum caeruloplasmin and serum copper concentration and with the total and available serum iron-binding capacity in 313 normal and abnormal subjects. In all groups except in patients with Wilson's disease (hepatolenticular degeneration) there was a highly significant direct correlation between serum ADA and serum caeruloplasmin concentration. A statistically significant direct correlation between serum ADA and the available iron-binding capacity of serum was found only in normal subjects and in children with thalassaemia major and iron overload. There wall no correlation between serum ADA and the serum tocopherol concentration in any of the groups studied.

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Section: Discussionmentioning

confidence: 99%

Serum Antioxidant Activity in Normal and Abnormal Subjects

et al. 1979

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“…Rice [13,14] observed some relationship between the ceruloplasm in level and the sedim entation rate, c-reactive protein, and fibrinogen in serum .…”

Section: Discussionmentioning

confidence: 99%

Serum Ceruloplasmin in Acute Viral Hepatitis

Hauftová¹,

Slaviček²,

Fialová³

et al. 1967

Digestion

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“…Caeruloplasmin has been widely used as a measure of 'acute phase reactivity' (Rice, 1961;Crockson et al, 1966). Like other alpha-globulins it tends to be raised whenever there is active tissue damage.…”

Section: In Vivo Activitymentioning

confidence: 99%

Caeruloplasmin: A Plasma Protein, Enzyme, and Antioxidant

Gutteridge

1978

Ann Clin Biochem

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Multifunctional roles of the plasma protein, caeruloplasmin, have been briefly reviewed under three main headings. These are protein functions, enzymic activity, and antioxidant protection. As a plasma protein it is said to play a role in the transport of copper. Since some 95 % of serum copper is associated with caeruloplasmin, measurement of the protein provides a useful guide to copper levels. Enzymic functions are related to its oxidase activity. Substrates commonly used for laboratory assay include non-biologically occurring aromatic amines and polyphenols. More recently, a physiological function has been proposed in which the enzyme oxidases iron from the ferrous to ferric state for binding to apotransferrin. This enzymic function of caeruloplasmin has been designated ‘ferroxidase’. In vitro studies have shown that caeruloplasmin can inhibit the peroxidation of polyunsaturated fatty-acids. This function is in part related to its ferroxidase activity. No antioxidant activity has yet been demonstrated in vivo but this possibility is speculatively discussed.

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Evaluation of the role of ceruloplasmin as an acute-phase reactant

Cited by 35 publications

References 8 publications

Serum Antioxidant Activity in Normal and Abnormal Subjects

Serum Antioxidant Activity in Normal and Abnormal Subjects

Serum Ceruloplasmin in Acute Viral Hepatitis

Caeruloplasmin: A Plasma Protein, Enzyme, and Antioxidant

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