Serum Antioxidant Activity in Normal and Abnormal Subjects

Abstract

SUMMARY Serum antioxidant activity (ADA) was correlated with the serum caeruloplasmin and serum copper concentration and with the total and available serum iron-binding capacity in 313 normal and abnormal subjects. In all groups except in patients with Wilson's disease (hepatolenticular degeneration) there was a highly significant direct correlation between serum ADA and serum caeruloplasmin concentration. A statistically significant direct correlation between serum ADA and the available iron-binding capacity of serum was found only in normal subjects and in children with thalassaemia major and iron overload. There wall no correlation between serum ADA and the serum tocopherol concentration in any of the groups studied.

Protective effect of the serum against cellular damage by active oxygen in culture.

“…These results suggest that the direct action of 02 is not responsible for the cell injuries in the present experiments. Cranfield (1979) reported that the antioxidant activity was partly related to iron free Tf as well as Cp, but in the present experiment pregnant, normal, and inflammatory sera in this order of concentration contained iron free Tf independently of antioxidant activity. Serum Fe was, however, inversely related to the number of viable cells.…”

Serum Antioxidant Activity in Uremic Patients

“…In addition to known scavengers protecting against celluar injury by oxygen free radicals [1][2][3], the presence of a potent AOA in serum was revealed by Dormandy [I, 22], Stocks et al [16] and Caranfield et al [23]. We deter mined the serum AOA in CRF patients using fresh ox brain homogenate according to the method of Stocks et al [16].…”

Causes of Oxidative Stress in the Pre- and Perinatal Period

“…Circulating levels of lipid peroxides increase significantly in the maternal circulation when a women becomes pregnant [5][6][7][8]. However, various antioxidants, such as vitamin E, ceruloplasmin, erythrocyte thiols [6] and iron-binding capacity [12,13] also increase. Several of these increase progressively with advancing gestation [14,15], while serum iron concentrations progressively decrease.…”