Evaluation of the role of thiol / disulfide homeostasis in the etiology of idiopathic male infertility with a novel and automated assay

Miçooğulları, Uygar; Çakıcı, Mehmet Çağlar; Kilic, Furkan Umut; Kısa, Erdem; Özçift, Burak; Çağlayan, Alper; Neşeli̇oğlu, Salim; Karataş, Ömer Faruk; Erel, Özcan

doi:10.1080/19396368.2021.2003481

Cited by 3 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the first authors to propose the term MOSI was Agarwal et al at 2019, as a novel descriptor for infertile men with abnormal semen characteristics and OS, including many patients who were previously classified as having idiopathic male infertility [ 5 ] (see Figure 1 ). Miccogullari et al have published a study on the role of thiol/disulfide homeostasis with a novel and automated assay in MOSI [ 22 ], for the determination of oxidant/antioxidant status in serum samples by using a novel test of patients with IMI and comparing their results to those of healthy controls.…”

Section: Certitudes In Male Infertilitymentioning

confidence: 99%

On Males, Antioxidants and Infertility (MOXI): Certitudes, Uncertainties and Trends

Alfaro Gómez,

Fernández-Santos,

Jurado-Campos

et al. 2023

Antioxidants

View full text Add to dashboard Cite

Male infertility (MI) involves various endogenous and exogenous facts. These include oxidative stress (OS), which is known to alter several physiological pathways and it is estimated to be present at high levels in up to 80% of infertile men. That is why since the late 20th century, the relationship between OS and MI has been widely studied. New terms have emerged, such as Male Oxidative Stress Infertility (MOSI), which is proposed as a new category to define infertile men with high OS levels. Another important term is MOXI: Male, Antioxidants, and Infertility. This term refers to the hypothesis that antioxidants could improve male fertility without the use of assisted reproductive technology. However, there are no evidence-based antioxidant treatments that directly improve seminal parameters or birth ratio. In this regard, there is controversy about their use. While certain scientists argue against their use due to the lack of results, others support this use because of their safety profile and low price. Some uncertainties related to the use of antioxidants for treating MI are their questionable efficacy or the difficulties in knowing their correct dosage. In addition, the lack of quality methods for OS detection can lead to excessive antioxidant supplementation, resulting in “reductive stress”. Another important problem is that, although the inflammatory process is interdependent and closely linked to OS, it is usually ignored. To solve these uncertainties, new trends have recently emerged. These include the use of molecules with anti-inflammatory and antioxidant potential, which are also able to specifically target the reproductive tissue; as well as the use of new methods that allow for reliable quantification of OS and a quality diagnosis. This review aims to elucidate the main uncertainties about MOXI and to outline the latest trends in research to develop effective therapies with clinically relevant outcomes.

show abstract

Section: Certitudes In Male Infertilitymentioning

confidence: 99%

On Males, Antioxidants and Infertility (MOXI): Certitudes, Uncertainties and Trends

Alfaro Gómez,

Fernández-Santos,

Jurado-Campos

et al. 2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…The shift in the balance in favor of oxidants defines OS. The thiol/disulfide equilibrium is an indicator of OS [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Serum and Follicular Fluid Thiol/Disulfide Homeostasis in Diminished Ovarian Reserve Patients Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection Treatment

Erdoğan¹,

Sanlier²,

Utlu³

et al. 2023

Cureus

View full text Add to dashboard Cite

Introduction: The etiologies of diminished ovarian reserve (DOR) are still poorly understood, and many factors such as age, autoimmunity, genetics, idiopathicity, iatrogenesis, and oxidative stress (OS) play a role. Oxidative cellular damage increases following reactive oxygen species (ROS)-induced aging. This is the first study to evaluate the serum and follicular fluid (FF) thiol/disulfide homeostasis in patients under 35 years of age with DOR undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Methods: In this study, DOR was defined by the Poseidon criteria, and Poseidon group 3 women were selected as the study group (n = 40). The control group was composed of patients with the diagnosis of mild-moderate male factor infertility (n = 30). Results: The FF and serum native and total thiol levels, the markers of the antioxidant system, were significantly decreased in the DOR group compared with the control group (p = 0.021) (p = 0.037) (p = 0.029) (p = 0.04). On the other hand, we found no significant differences in the oxidant parameters between the groups (p > 0.05). Conclusions: An intrinsic deficiency of antioxidants can play an important role in the etiology of DOR. The dietary addition of antioxidants could be beneficial in DOR patients.

show abstract

Effect of vitamin D on oxidative stress indices and ram semen parameters

Teymoori,

Mohri,

Mirshokraei

2024

Small Ruminant Research

View full text Add to dashboard Cite

Evaluation of the role of thiol / disulfide homeostasis in the etiology of idiopathic male infertility with a novel and automated assay

Cited by 3 publications

References 20 publications

On Males, Antioxidants and Infertility (MOXI): Certitudes, Uncertainties and Trends

On Males, Antioxidants and Infertility (MOXI): Certitudes, Uncertainties and Trends

Serum and Follicular Fluid Thiol/Disulfide Homeostasis in Diminished Ovarian Reserve Patients Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection Treatment

Effect of vitamin D on oxidative stress indices and ram semen parameters

Contact Info

Product

Resources

About