Evaluation of the Roche cobas® CT/NG Test for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Male Urine

Taylor, Stephanie N.; Liesenfeld, Oliver; Lillis, Rebecca A.; Body, Barbara A.; Nye, Melinda B.; Williams, James A.; Eisenhut, Carol; Hook, Edward W.; Pol, Barbara Van Der

doi:10.1097/olq.0b013e31824e26ff

Cited by 37 publications

(24 citation statements)

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“…Despite neisseria gonorrhoeae and c hlamydia trachomatis being the most common causes of urethritis in men, we found a significant number of NGNC cases [2, 15]. This can present a significant challenge for medical providers and specialists.…”

Section: Discussionmentioning

confidence: 98%

Mp25-10 Etiology of Symptomatic Urethritis in Men According to Sexual Behaviors

et al. 2015

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INTRODUCTION Gonorrhea and chlamydia are sexually transmitted infections (STI) that are the most common causes of urethritis in men. The role of specific sexual behaviors and presentation of urethritis is often overlooked. METHODS Data was retrospectively reviewed on all men presenting at the major STI clinic in Providence, Rhode Island. Predictors of gonorrhea and chlamydia infection were modeled using a generalized model assuming a binary distribution. RESULTS Of the men with urethritis, 27% had chlamydia, 13% gonorrhea, 3% both, and 63% neither (non-gonococcal, non-chlamydial urethritis). MSM were more likely to test positive for gonorrhea than MSW (25% of MSM versus 6% of MSW; p<0.01). CONCLUSIONS MSM with urethritis were much more likely to test positive for gonorrhea which may be due to increased risk behaviors and spread within concentrated sexual networks. A large number of both MSM and MSW had non-gonococcal, non-chlamydial urethritis, which suggests the need for improved diagnostic testing.

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Section: Discussionmentioning

confidence: 98%

Mp25-10 Etiology of Symptomatic Urethritis in Men According to Sexual Behaviors

et al. 2015

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“…For the routine detection of C. trachomatis in males, firstvoid urine is currently the specimen of choice (Bébéar & de Barbeyrac, 2009;Taylor et al, 2012). However, an obvious alternative test specimen to consider in an infertility setting is semen.…”

Section: Discussionmentioning

confidence: 99%

“…An increasing number of laboratories are now offering combinatorial NAATs for the diagnosis of both C. trachomatis and Neisseria gonorrhoeae infections (Gaydos et al, 2010;Hopkins et al, 2010;Rockett et al, 2010;Cheng et al, 2011;Kerndt et al, 2011). The Roche Diagnostics cobas CT/NG test, performed on the cobas 4800 system, is a new commercialized diagnostic assay using an automated workstation to isolate nucleic acids from clinical specimens and a real-time instrument for the detection of C. trachomatis and N. gonorrhoeae (Rockett et al, 2010;Taylor et al, 2012;Van Der Pol et al, 2012). Self-collected vaginal swabs in women and male urine samples have been cleared by the US Food and Drug Administration for use with commercial NAATs.…”

Section: Introductionmentioning

confidence: 99%

Swabs (dry or collected in universal transport medium) and semen can be used for the detection of Chlamydia trachomatis using the cobas 4800 system

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Papaxanthos

Liesenfeld

et al. 2013

Journal of Medical Microbiology

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“…Infecciones de Transmisión Sexual je 22,[31][32][33]38 . En dichos estudios los rangos de prevalencia de infección por C. trachomatis en mujeres asintomáticas menores de 26 años oscilaron entre 4 y 5,8% en una corte de más de 2.200 muestras analizadas.…”

Section: Artículo Originalunclassified