Evaluation of the Reproducibility of the Naranjo Adverse Drug Reaction Probability Scale Score in Published Case Reports

Liang, Ruby; Borgundvaag, Bjug; McIntyre, Mark; Thwaites, Crystal; Ragan, Kelsey; Wyllie, Andrew H.

doi:10.1002/phar.1496

Cited by 20 publications

(13 citation statements)

References 38 publications

(30 reference statements)

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“…As some adverse drug reactions are similar to the symptoms of COVID-19, clinical pharmacists needed to help patients to understand the concept of adverse drug reactions appropriately, and know how to distinguish minor side effects and severe drug reactions that needs medical intervention using the causality assessment tool of Naranjo Adverse Reaction Probability Scale (APS). 15 After the online patient interviews, we found that 38%…”

Section: Ta B L Ementioning

confidence: 99%

Evaluation of the role and usefulness of clinical pharmacists at the Fangcang Hospital during COVID‐19 outbreak

et al. 2021

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Section: Ta B L Ementioning

confidence: 99%

Evaluation of the role and usefulness of clinical pharmacists at the Fangcang Hospital during COVID‐19 outbreak

et al. 2021

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“…Also, other patients did not experience such complications. However, based on the Naranjo causality assessment criterion [30], the probability of developing this complication as a result of treatment is in the possible class.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of high dose intravenous vitamin C on delayed allograft function in deceased donor kidney transplantation: a preliminary report

et al. 2020

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Background: Delayed graft function (DGF) can affect short-and long-term allograft outcomes in kidney transplant recipients. One of the pathophysiological pathways in the occurrence of DGF is ischemia-reperfusion injury (IRI). High dose intravenous vitamin C has proven efficacy in decreasing IRI consequences. Accordingly, we designed this study to assess the effect of high dose intravenous vitamin C on the incidence and duration of DGF. Methods: This is a pilot, single-center, double-blinded, randomized, placebo-controlled trial. In the treatment group, kidney transplant recipients received vitamin C infusion at the dose of 70 mg/kg diluted in 0.45% saline, and in another study arm, only the diluent solution was administered. Data regarding allograft function and other clinical information was recorded. Results: This preliminary study on 19 patients (9 cases in the vitamin C and 10 cases in the placebo group) showed that after administration of single, high dose vitamin C the incidence of DGF was not significantly different between the groups, but the duration of DGF was substantially shorter in the vitamin C group than the placebo group (7.33 ± 5.68 versus 19.66 ± 0.57 days; P = 0.02). Acute rejection episodes were more seen in the vitamin C group than in the placebo group. Although this data was not statistically significant (P = 0.37), it led to the termination of the study. Conclusion: A high dose of intravenous vitamin C before allograft implantation was effective in decreasing DGF duration but not DGF incidence. Trial registration: The trial was registered in the Iranian registry of clinical trials encoded IRCT20100111003043N13 on June 24, 2019.

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“…In order to further highlight the relationship between AED treatment and appearance of cutaneous signs the ADR probability scale of Naranjo et al ( 26 ), a classification system validated in human medicine ( 32 , 33 ), was applied. This scale estimates the likelihood of an ADR based on a number of criteria (Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs

et al. 2016

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Epilepsy is one of the most common neurologic disorders in dogs and life-long treatment with antiepileptic drugs (AED) is frequently required. Adverse events of AED targeting the skin are only rarely reported in veterinary medicine and the true incidence and spectrum of cutaneous reactions in epileptic dogs remains unknown. In this study, we hypothesized that cutaneous reactions commonly occur in epileptic dogs and are related to AED treatment. A retrospective case review of 185 dogs treated for epilepsy identified 20.0% with simultaneous appearance of dermatologic signs. In a subsequent prospective case investigation (n = 137), we identified newly appearing or distinct worsening of skin lesions following initiation of AED therapy in 10.9% of dogs treated for epilepsy (95% CI 6.8–17.7%). Cutaneous lesions were classified as probably drug-induced in 40.0% of these cases. Patch testing and intradermal testing were further investigated as potential diagnostic methods to confirm AED hypersensitivity. They were of high specificity but sensitivity and positive predictive value appeared inappropriate to recommend their routine use in clinical practice.

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Evaluation of the Reproducibility of the Naranjo Adverse Drug Reaction Probability Scale Score in Published Case Reports

Abstract: Exact agreement between raters' scores and the published APS score was infrequent. We recommend that authors of case reports include all pertinent details of the case and that journals ensure the robustness of the causality assessment during peer review.

Cited by 20 publications

References 38 publications

Evaluation of the role and usefulness of clinical pharmacists at the Fangcang Hospital during COVID‐19 outbreak

Evaluation of the role and usefulness of clinical pharmacists at the Fangcang Hospital during COVID‐19 outbreak

Evaluation of the effect of high dose intravenous vitamin C on delayed allograft function in deceased donor kidney transplantation: a preliminary report

Cutaneous Adverse Drug Reactions in Dogs Treated with Antiepileptic Drugs

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