Evaluation of the release of nickel and titanium under orthodontic treatment

Velasco-Ibáñez, Rafael; Lara-Carrillo, Edith; Morales‐Luckie, Raúl A.; Romero-Guzmán, Elizabeth Teresita; Toral-Rizo, Víctor Hugo; Ramírez-Cardona, Màrius; García-Hernández, Verónica; Medina-Solís, Carlo Eduardo

doi:10.1038/s41598-020-79221-1

Cited by 18 publications

(14 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In view of the fact that metallic orthodontic appliances are still in active use, this represents an opportunity to study changes in oral tissue developing in patients undergoing orthodontic treatment, considering that the treatment periods are often lengthy. Most of the materials used in orthodontics are made of stainless steel, which contains chrome and iron; these metals have been associated with DNA damage due to corrosive effects [13,14]. Among the components of the alloys present in metallic materials, previous studies have indicated that nickel (Ni) is potentially the most damaging in terms of cytotoxicity [6,7,9,[15][16][17], allergy [18][19][20][21], mutagenesis [6,17,22] and/ or bioaccumulation [16][17][18]21].…”

Section: Discussionmentioning

confidence: 99%

Use of liquid-based cytology samples reveals genomic instability and cell death in patients undergoing orthodontic treatment

Carrillo-Novia¹,

Lara-Carrillo²,

Torres-Bugarı́n

et al. 2023

J Oral Sci

Self Cite

View full text Add to dashboard Cite

Purpose: To examine the use of liquid-based exfoliative cytology to determine the presence of genomic instability and cell death in the oral mucosa of patients with orthodontic appliances. Methods: Fifty-four oral mucosa samples were collected from 18 patients and divided into three stages: T0, before fixation of orthodontic appliances; T1, 25 days after appliance fixation; T2, 90 days after appliance fixation. All samples were Papanicolaou-stained and observed by microscopy (1,000 cells/sample) to ascertain the frequency of micronucleated cells (MN) and nuclear abnormalities (nuclear buds (NB), binucleated (BN), condensed chromatin (CC), karyorrhexis (KR), and karyolysis (KL)). Differences were analyzed statistically using the Mann-Whitney, Wilcoxon, Kruskal-Wallis and chi-squared tests. Results: After placement of orthodontic appliances, significant differences were observed for genomic instability biomarkers (MN and NB) and cell death (CC, KR and KL) (P < 0.05). Female patients and older patients exhibited a higher frequency of MN. Conclusion: Liquid-based cytology has revealed that orthodontic appliances induce genomic instability and cell death in epithelial tissue of the oral mucosa, facilitating sample preservation and yielding more than one preparation per sample. Future studies should investigate whether such cell damage can be reversed through cell repair or whether cell alterations evolve and lead to disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Use of liquid-based cytology samples reveals genomic instability and cell death in patients undergoing orthodontic treatment

Carrillo-Novia¹,

Lara-Carrillo²,

Torres-Bugarı́n

et al. 2023

J Oral Sci

Self Cite

View full text Add to dashboard Cite

show abstract

“…Oral cavity diseases may be developed as a result of changes in the oral fluid characteristics, including pH, which can modify the properties of dental materials [ 1 , 44 , 45 , 46 ]. Other researchers have highlighted the correlation between salivary pH and changes in the characteristics of tooth structure and in the restorative dental materials [ 42 , 43 , 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Salivary pH, Buffer Capacity, and Flow in Patients with and without Gastroesophageal Reflux Disease

Bechir

Cuc

Tohati

et al. 2021

IJERPH

View full text Add to dashboard Cite

The oral cavity has specific and individualized characteristics, with pH, saliva flow, buffer capacity, temperature, and microorganisms content influencing oral health. Currently, the prevalence of gastroesophageal reflux disease (GERD) is constantly increasing. The objective of this study was to evaluate and compare the saliva quantity at 5 min, salivary pH, and salivary buffer capacity in patients with and without GERD, necessary for establishing the correct dental treatment plan. A Saliva-Check Buffer (GC) kit was used for the determination of salivary variables. The total number of 80 patients included in the study were divided into a study group and a control group, each containing 40 patients. Saliva quantity at 5 min was lower in patients suffering from GERD. The salivary pH of these patients turned to acid values compared to the salivary pH of controls, where the values were within the normal range. In patients with GERD, the determined salivary buffer capacity was low or very low. The use of the Saliva-Check Buffer (GC) kit is a simple, easy, non-invasive and patient-accepted method, which can also be used in the dentist’s office to assess the saliva buffer capacity and pH, variables that are important for establishing a correct dental treatment plan.

show abstract

“…Besides, NiTi or SS archwires are used simultaneously with the studied components [2] and may contribute with more metal release into the oral cavity [39]. In a recent study [63], other authors found a significant increase in Ni concentration in the urine of patients undergoing orthodontic treatment, encouraging further research on bioaccumulation of this metal. Orthodontic appliances may be an additional source of potentially toxic elements that should not be disregarded [39], particularly for patients hypersensitive to Ni.…”

Section: Orthodontic Componentsmentioning

confidence: 99%

Salivary pH Effect on Orthodontic Appliances: In Vitro Study of the SS/DLC System

et al. 2021

View full text Add to dashboard Cite

Stainless steels (SS) are the most-used alloys for manufacturing fixed orthodontic appliances due to their attractive set of mechanical properties, biocompatibility, and high corrosion resistance. Nevertheless, during regular orthodontic treatments–taking at least around 2 years–the intraoral environment inevitably degrades these bioalloys, releasing metallic ions into the oral cavity. In the first part of this in vitro study, the corrosion resistance of commercial SS appliances (brackets, tubes, and bands) was evaluated in Fusayama-Meyer artificial saliva at pH values of 2.3 and 6.8 over the course of 30 days. As expected, the results corroborated that salivary pH highly influences corrosion behaviour. Released Ni, Cr, and Fe were within dietary intake values. In the second part, a novel approach for oral corrosion prevention based on the chemical inertness of DLC materials is presented. SS surfaces were functionalized with biocompatible a-C:H-sputtered coatings and submitted to the same experimental conditions. The anticorrosion ability of this system was demonstrated, preventing the pitting corrosion that occurred on the SS substrates. Despite the galvanic coupling effect due to the presence of the Cr-based interlayer, this study enhanced the potential use of the reactive sputter-deposited a-C:H coatings in orthodontics.

show abstract

Evaluation of the release of nickel and titanium under orthodontic treatment

Cited by 18 publications

References 44 publications

Use of liquid-based cytology samples reveals genomic instability and cell death in patients undergoing orthodontic treatment

Use of liquid-based cytology samples reveals genomic instability and cell death in patients undergoing orthodontic treatment

Comparative Study of Salivary pH, Buffer Capacity, and Flow in Patients with and without Gastroesophageal Reflux Disease

Salivary pH Effect on Orthodontic Appliances: In Vitro Study of the SS/DLC System

Contact Info

Product

Resources

About