Evaluation of the relative efficacy of autologous platelet-rich plasma in combination with β-tricalcium phosphate alloplast versus an alloplast alone in the treatment of human periodontal infrabony defects: A clinical and radiological study

Abstract

Combination of PRP and β-TCP led to a significantly more favorable clinical and radiographic improvement in infrabony periodontal defects.

A clinical and radiographic evaluation of the management of periodontal osseous defects with alloplast and platelet rich plasma

“…However, comparison between the two groups revealed no statistically significant difference in the reduction of radiographic defect depth or the defect fill when measured at 6 and 9 months respectively. The results of this inter group comparison were found to be similar to the results of previously conducted studies by Camargo PM et al, (2009) [40] and Saini N et al, (2011) [35], where they found significant improvement in the test sites as compared to control sites in defect depth reduction and bone fill. Significant improvement in clinical and radiological parameters both at test and control sites may also be attributed to the physical characteristic of the regenerative materials used.…”

“…Similar results on comparison between two groups were obtained in previous studies [23,24,[31][32][33][34], but contradictory results were found by Saini N et al, (2011), where there was significant reduction in PPD in test group compared to control group [35].…”

“…The results of the test sites compare favorably with earlier studies of Hanna R et al, (2004) [28] and [22] whereas the results at control sites where in accordance to the studies of Drizhal et al, (2010) [37] and Sukumar et al, (2011) [38]. Comparison between the two groups revealed no statistically significant difference in the reduction of clinical attachment level when measured at different points of time during the study, in contrast to the study of [22] and Saini et al, (2011) [35] where a statistically significant gain in clinical attachment was reported with PRP in combination with other alloplastic materials, when compared to bone grafts alone [12]. The gain in the clinical attachment level has been thought to represent resolution of tissue inflammation, reformation of collagen fibers, new attachment to the root surface and the bone fill [39].…”

Implication of Platelet Rich Plasma- As an Adjuant to Hydroxyapatite in the Treatment of Periodontal Infra Bony Defects -A Controlled Randamized Clinical and Radiological Study

“…The platelet rich plasma + hydroxyapatite group showed a significantly greater probing depth reduction of (6.1± 3.6 mm) and relative attachment gain (7.1±4.1 mm) when compared to the saline hydroxyapatite who showed a probing depth reduction [15], Saini N et al 2011 [16], Kaushick BT et.al 2011 [17].Shreya Shetty et.al(2013) [18].Shakshi et.al have conducted a clinical study on platelet rich plasma and allograft and have concluded that platelet rich plasma enchances better regeneration with combined to allografts…”

Evaluaton of the Use of Bone Implants as a Therapy for Deep Defects in the Parodoncium

“…Lukovic and associates conducted a clinical study that showed Cerasorb and Bioss have similar efficacies as a treatment for deep infrabony pockets (14). Saini and associates found limited improvement using beta tricalcium phosphate to treat infrabony defects and determined that beta tricalcium phosphate in combination with biologically active factors provides a significantly better result (15). Jansen and associates showed that the main shortcoming of beta tricalcium phosphate is its fast resorption and that priority in the treatment of bony defects should be given to autogenous transplants (16).…”