Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma

Abstract

Backgroundc-Kit is a proto-oncogene that encodes tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker, providing information on platelet function and diameter.ObjectiveTo investigate c-Kit expression and intensity in patients with Kaposi's sarcoma (KS) and to investigate the relation between Ki-67 proliferation and MPV.MethodsA total of 32 patients, diagnosed with classic cutaneous KS, were included in this study. We reevaluated the histopathological reports with the preparations, confirmed the diagnosis and then determined the patients' histopathological stages. c-Kit expression and Ki-67 proliferation were investigated immunohistochemically in KS cases, while MPV in all cases was checked.ResultsAlthough c-Kit expression was detected in 22 cases (68.8%), it was not expressed in 10 cases (31.2%). We detected 8 cases with + (25%), 6 with ++ (18.8%) and 8 with +++ (25%). Ki-67 expression was 5.0% (min-max 1.0-20.0). Relapse was observed in 5 cases (15.6%) out of 32. There was positive correlation between c-Kit expression and MPV (rs=0.598, p<0.001), and between c-Kit intensity and MPV (rs=0.588, p<0.001).Conclusionc-Kit is highly positive in KS. c-Kit positivity indicates a high risk of tumor growth, invasion and relapse. Furthermore, c-Kit expression stimulates megakaryocytes to release young and large thrombocytes into the periphery. Thus, high MPV, c-Kit expression and immunostaining intensity indicate high invasion and relapse in KS subjects.

Expression of AMHR2 and C-KIT in cervical lesions in Uyghur Women of Xinjiang, China

“…[29] Furthermore, c-Kit is a mutagenic effective proto-oncogene with a stem-cell factor (SCF) as a ligand, and it leads to tumor growth through impairment of cellular growth regulation. [30] In our study, c-Kit increased in cervical cancer sections obviously while cervicitis sections were mainly expressed negatively. And it expressed increasingly as the cervical cancer's differentiation degree decreased.…”

Loss of c-KIT expression in thyroid cancer cells

“…Furthermore, c-KIT is a mutagenic effective proto-oncogene with a stem-cell factor (SCF) as a ligand, and it leads to tumor growth through impairment of cellular growth regulation [6]. …”

“…The proto-oncogene c-KIT encodes for the tyrosine kinase receptor (CD117) and is involved in cell signal transduction with different downstream pathways: MAPK, phosphatidylinositol 3-kinases (PI3K), Janus kinase (JAK)/signal transducers and activators of transcription (STAT), SRC family kinases (SFK) and phospholipase Cγ [ 5 ]. Furthermore, c-KIT is a mutagenic effective proto-oncogene with a stem-cell factor (SCF) as a ligand, and it leads to tumor growth through impairment of cellular growth regulation [ 6 ].…”

The Potential Diagnostic Utility of TROP-2 & C-Kit in Thyroid Neoplasms

“…The proto-oncogene c-Kit encodes for the tyrosine kinase receptor (CD117) and is involved in cell signal transduction with different downstream pathways: MAPK, phosphatidylinositol 3-kinases (PI3K), Janus kinase (JAK)/signal transducers and activators of transcription (STAT), SRC family kinases (SFK) and phospholipase Cγ [13]. Furthermore, c-Kit is a mutagenic effective proto-oncogene with a stem-cell factor (SCF) as a ligand, and it leads to tumor growth through impairment of cellular growth regulation [14]. Normally c-Kit is activated (phosphorylated) by binding of its ligand, the stem cell factor.…”