Expression of AMHR2 and C-KIT in cervical lesions in Uyghur Women of Xinjiang, China

Taximaimaiti, Reyisha; Abudujilile, Dilinuer; Maihemuti, Muzhapaer; Abuliken, Xiekelai; Abudulimu, Haimiti

doi:10.1097/md.0000000000010793

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…A high occurrence rate of cervical cancer occurs in Chinese Uyghur women; a study has been focused on OXR1 and OXR2 expressions in these women with cervical cancer and in patients with cervicitis [91]. The study showed that OXR2 was overexpressed in women with cervical cancer when compared with those showing cervicitis; however, no difference was found in both groups regarding OXR1 expression [91].…”

Section: Cervical Cancermentioning

confidence: 97%

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Involvement of the Orexinergic System in Cancer: Antitumor Strategies and Future Perspectives

Rabal

Coveñas

2023

Applied Sciences

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Peptides promote the mitogenesis and migration of tumor cells, and cancer cells overexpress peptide receptors. The involvement of the orexinergic system in cancer is reviewed here, including thirteen cancer types (e.g., adrenocortical adenoma, breast, colon, gastric, liver, neuroblastoma, pancreas, prostate). An upregulation of the orexinergic system has been reported in many tumors, and orexin receptors (OXRs) mediate a dual effect: apoptosis in some tumors and a proliferative action in others. OXR antagonists or agonists are potential antitumor agents against tumors expressing OXRs. The complexities of the biological processes associated with the orexigenic system are also described in the review, as they may provide the basis for the development of new therapies: OXR dimerization/oligomerization, epigenetic mechanisms controlling the orexinergic system, possible biomarkers of this system for tumor risk/prognosis, protective effects mediated by orexins against chemotherapeutic drugs, the combination therapy of OXR antagonists/agonists with radiotherapy or chemotherapy, and the anti-inflammatory effects mediated by orexins. Taking these data into account, future therapeutic applications as well as research lines to be developed are also mentioned and discussed. This knowledge will allow for the development of antitumor strategies in the future.

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Section: Cervical Cancermentioning

confidence: 97%

“…[90] Cervical cancer OXR2 overexpression. [91] Colon cancer OXR1 expression. Orexins promoted apoptosis and decreased tumor volume.…”

Section: Acute Lymphoblastic Leukemiamentioning

confidence: 99%

Involvement of the Orexinergic System in Cancer: Antitumor Strategies and Future Perspectives

Rabal

Coveñas

2023

Applied Sciences

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Association of CD133, ALDH1, CD117 and OCT4 expression with prognosis of patients with cervical cancer

Almeida,

dos Santos,

Saddi

et al. 2024

Virchows Arch

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Expression of AMHR2 and C-KIT in cervical lesions in Uyghur Women of Xinjiang, China

Abstract: AMHR2 might have some correlation with self defense of our body, while c-Kit might link with the potential invasive capacity of cervical cancer.

Cited by 2 publications

References 33 publications

Involvement of the Orexinergic System in Cancer: Antitumor Strategies and Future Perspectives

Involvement of the Orexinergic System in Cancer: Antitumor Strategies and Future Perspectives

Association of CD133, ALDH1, CD117 and OCT4 expression with prognosis of patients with cervical cancer

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